NP_001123536.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,766 Da
NCBI Official Full Name
neuromodulin isoform 1
NCBI Official Synonym Full Names
growth associated protein 43
NCBI Official Synonym Symbols
NCBI Protein Information
neuromodulin; axonal membrane protein GAP-43; calmodulin-binding protein P-57; growth-associated protein 43; nerve growth-related peptide GAP43; neural phosphoprotein B-50; neuron growth-associated protein 43; protein F1
UniProt Protein Name
Neuromodulin
UniProt Synonym Protein Names
Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46
UniProt Entry Name
NEUM_HUMAN
NCBI Summary for GAP43
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GAP43
GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 3q13.31
Cellular Component: filopodium membrane; axon; cytoplasm; postsynaptic density; plasma membrane; cell junction
Molecular Function: calmodulin binding; protein binding
Biological Process: cell fate commitment; glial cell differentiation; tissue regeneration; regulation of growth; protein kinase C activation; axon choice point recognition; response to wounding; regulation of filopodium formation
Research Articles on GAP43
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Products associated with anti-GAP43 antibody
Pathways associated with anti-GAP43 antibody
Diseases associated with anti-GAP43 antibody
Organs/Tissues associated with anti-GAP43 antibody
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