AAO60065.1
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UniProt Secondary Accession #
Molecular Weight
Calculated MW: 25 Observed MW: 38, 43
NCBI Official Full Name
GAP43
UniProt Protein Name
Neuromodulin
UniProt Synonym Protein Names
Axonal membrane protein GAP-43; Calmodulin-binding protein P-57; Growth-associated protein 43
UniProt Entry Name
NEUM_BOVIN
UniProt Comments for GAP43
GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface
Cellular Component: axon; cell junction; cytoplasm; filopodium membrane; postsynaptic density
Molecular Function: calmodulin binding
Biological Process: axon choice point recognition; cell fate commitment; glial cell differentiation; regulation of filopodium formation; regulation of growth
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