AAH51342.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,106 Da
NCBI Official Full Name
GATA binding protein 2
NCBI Official Synonym Full Names
GATA binding protein 2
NCBI Protein Information
endothelial transcription factor GATA-2
UniProt Protein Name
Endothelial transcription factor GATA-2
UniProt Synonym Protein Names
GATA-binding protein 2
NCBI Summary for GATA2
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
UniProt Comments for GATA2
GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: nucleoplasm; nucleus; transcription factor complex
Molecular Function: chromatin binding; DNA binding transcription factor activity; protein binding; transcription factor binding; zinc ion binding
Biological Process: blood coagulation; cell differentiation in hindbrain; cell fate determination; cell maturation; central nervous system neuron development; cochlea development; commitment of a neuronal cell to a specific type of neuron in the forebrain; elevation of cytosolic calcium ion concentration; embryonic placenta development; homeostasis of number of cells within a tissue; inner ear morphogenesis; negative regulation of endothelial cell apoptotic process; negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; negative regulation of macrophage differentiation; negative regulation of neural precursor cell proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neuron migration; phagocytosis; pituitary gland development; positive regulation of angiogenesis; positive regulation of erythrocyte differentiation; positive regulation of mast cell degranulation; positive regulation of megakaryocyte differentiation; positive regulation of neuron differentiation; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of transcription from RNA polymerase II promoter; regulation of forebrain neuron differentiation; regulation of hematopoietic stem cell differentiation; regulation of histone acetylation; regulation of primitive erythrocyte differentiation; response to lipid; somatic stem cell maintenance; transcription from RNA polymerase II promoter; transcription, DNA-dependent; urogenital system development; ventral spinal cord interneuron differentiation
Disease: Immunodeficiency 21; Lymphedema, Primary, With Myelodysplasia; Myelodysplastic Syndrome
Research Articles on GATA2
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Products associated with anti-GATA2 antibody
Pathways associated with anti-GATA2 antibody
Diseases associated with anti-GATA2 antibody
Organs/Tissues associated with anti-GATA2 antibody
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