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anti-GATA1 antibody :: Rabbit GATA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS630140 anti-GATA1 antibody
Unit / Price
0.05 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GATA1, Polyclonal Antibody

 Also Known As   

GATA1, phosphorylated (Ser142) (Erythroid Transcription Factor, Eryf1, GATA-binding Factor 1, GATA-1, GF-1, NF-E1 DNA-binding Protein, ERYF1, GF1)

 Product Synonym Names    Anti -GATA1, phosphorylated (Ser142) (Erythroid Transcription Factor, Eryf1, GATA-binding Factor 1, GATA-1, GF-1, NF-E1 DNA-binding Protein, ERYF1, GF1)
 Product Gene Name   

anti-GATA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (48644982..48652718). Location: Xp11.23
 OMIM    300367
 3D Structure    ModBase 3D Structure for P15976
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human GATA1 when phosphorylated at serine 142. Species Cross-Reactivity: mouse, rat.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
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 Immunogen    Synthetic phosphopeptide corresponding to human GATA-1 around the phosphorylation site of serine 142 (R-L-SP-P-D).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-GATA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GATA1 antibody

   Globin transcription factor 1 (GATA-1) is a transcription activator belonging to the GATA family of transcription factors with importance in cell growth. GATA-1 is a Cys2-Cys2 zinc finger DNA binding protein commonly found in erthroid (red blood cell) and emagkaryotic (platelet producing cell) and it is critical in the development process of both. It binds to the consensus sequence of [AT]GATA[AG] within regulatory regions of globin genes and genes in erythroid cells, leading to transcription of alpha spectrin structural protein necessary for red blood cell's shape. In human, GATA-1 can enhance transcription rate up to 100 times. Mutation to GATA-1 encoding gene has been implicated to X-linked dyserythropoietic anemia, thrombocytopenia, Down's syndrome in children, congenital transient myeloproliferative syndrome, and acute megakaryocytic leukemia.
 Product Categories/Family for anti-GATA1 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-GATA1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-GATA1 antibody    Suitable for use in Immunofluorescence, Western Blot, and Immunohistochemistry.
Dilution: Immunofluorescence: 1:100-1:200
Western Blot: 1:500-1:1,000
Immunohistochemistry: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for GATA1. It may not necessarily be applicable to this product.
 NCBI GI #    14602571
 NCBI GeneID    2623
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 UniProt Primary Accession #    P15976 [Other Products]
 UniProt Secondary Accession #    Q96GB8 [Other Products]
 UniProt Related Accession #    P15976 [Other Products]
 Molecular Weight    42,751 Da [Similar Products]
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 NCBI Official Full Name    GATA1 protein
 NCBI Official Synonym Full Names    GATA binding protein 1 (globin transcription factor 1)
 NCBI Official Symbol    GATA1 [Similar Products]
 NCBI Official Synonym Symbols   
GF1; GF-1; NFE1; XLTT; ERYF1; GATA-1
[Similar Products]
 NCBI Protein Information    erythroid transcription factor; OTTHUMP00000023259; OTTHUMP00000023260; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; globin transcription factor 1; erythroid transcription factor 1
 UniProt Protein Name    Erythroid transcription factor
 UniProt Synonym Protein Names   
Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein
 Protein Family    GATA transcription factor
 UniProt Gene Name    GATA1 [Similar Products]
 UniProt Synonym Gene Names    ERYF1; GF1 [Similar Products]
 UniProt Entry Name    GATA1_HUMAN
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 NCBI Summary for GATA1    This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq]
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 UniProt Comments for GATA1    GATA1: Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with EP300. Erythrocytes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: nucleoplasm; transcription factor complex; transcriptional repressor complex; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; p53 binding; chromatin DNA binding; sequence-specific DNA binding; transcription factor activity; DNA bending activity

Biological Process: transcription from RNA polymerase II promoter; erythrocyte development; megakaryocyte differentiation; embryonic hemopoiesis; in utero embryonic development; positive regulation of erythrocyte differentiation; eosinophil differentiation; male gonad development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; negative regulation of bone mineralization; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of osteoblast proliferation; erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; platelet formation; blood coagulation; basophil differentiation; negative regulation of apoptosis

Disease: Thrombocytopenia With Beta-thalassemia, X-linked; Down Syndrome; Thrombocytopenia, X-linked, With Or Without Dyserythropoietic Anemia; Anemia, X-linked, With Or Without Neutropenia And/or Platelet Abnormalities
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 Research Articles on GATA1    1. The genome-wide binding sites for the GATA1 in primary human megakaryocytes to identify the essential regulator of complex mammalian differentiation processes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GATA1 antibodyPathways associated with anti-GATA1 antibody
 Reference Product  PubMed Publications
 ZFPM1 antibody  >61 publications with GATA1 and ZFPM1
 LMO2 antibody  >44 publications with GATA1 and LMO2
 FLI1 antibody  >26 publications with GATA1 and FLI1
 STAT3 antibody  >15 publications with GATA1 and STAT3
 CASP3 antibody  >8 publications with GATA1 and CASP3
 ZFPM2 antibody  >7 publications with GATA1 and ZFPM2
 CREBBP antibody  >5 publications with GATA1 and CREBBP
 SPI1 antibody  >5 publications with GATA1 and SPI1
 CEBPE antibody  >4 publications with GATA1 and CEBPE
 MAPK1 antibody  >3 publications with GATA1 and MAPK1
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 Signaling Events Mediated By HDAC Class II Pathway antibodies  Signaling Events Mediated By HDAC Class II Pathway Diagram
Diseases associated with anti-GATA1 antibodyOrgans/Tissues associated with anti-GATA1 antibody
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >315 publications with GATA1 and Leukemia
 Neoplasms Antibodies  >271 publications with GATA1 and Neoplasms
 Hematologic Diseases Antibodies  >248 publications with GATA1 and Hematologic Diseases
 Leukemia, Myeloid Antibodies  >223 publications with GATA1 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >199 publications with GATA1 and Leukemia, Myeloid, Acute
 Down Syndrome Antibodies  >124 publications with GATA1 and Down Syndrome
 Congenital Abnormalities Antibodies  >113 publications with GATA1 and Congenital Abnormalities
 Anemia Antibodies  >105 publications with GATA1 and Anemia
 Leukemia, Erythroblastic, Acute Antibodies  >73 publications with GATA1 and Leukemia, Erythroblastic, Acute
 Thrombocytopenia Antibodies  >55 publications with GATA1 and Thrombocytopenia
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >147 publications with GATA1 and Bone Marrow
 Lung Antibodies  >21 publications with GATA1 and Lung
 Muscle Antibodies  >10 publications with GATA1 and Muscle
 Connective Tissue Antibodies  >4 publications with GATA1 and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with GATA1 and Uncharacterized Tissue
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