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anti-GATA6 antibody :: Rabbit anti-Human GATA6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS626891 anti-GATA6 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GATA6, Polyclonal Antibody

 Also Known As   

GATA6, phosphorylated (Tyr271) (GATA Binding Factor 6, GATA Binding Protein 6, Transcription Factor GATA-6)

 Product Synonym Names    Anti -GATA6, phosphorylated (Tyr271) (GATA Binding Factor 6, GATA Binding Protein 6, Transcription Factor GATA-6)
 Product Gene Name   

anti-GATA6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 18; NC_000018.9 (19749416..19782227). Location: 18q11.1-q11.2
 3D Structure    ModBase 3D Structure for Q05CA6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human GATA6 when phosphorylated at Tyr271.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic phosphopeptide corresponding to amino acid residues surrounding Tyr271 of human GATA6 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-GATA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GATA6 antibody

   GATA6 may be important for regulating terminal differentiation and/or proliferation.
 Product Categories/Family for anti-GATA6 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-GATA6 antibody   

ELISA (EL/EIA), Gel Shift Assay (GS/EMSA)

 Application Notes for anti-GATA6 antibody    Suitable for use in ELISA and Dot Blot.
Dilution: ELISA: 1:1,000
Dot Blot: 1:500
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NCBI/Uniprot data below describe general gene information for GATA6. It may not necessarily be applicable to this product.
 NCBI GI #    116283505
 NCBI GeneID    2627
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 UniProt Primary Accession #    Q05CA6 [Other Products]
 UniProt Related Accession #    Q05CA6; Q53EU2; Q92908 [Other Products]
 Molecular Weight    17,243 Da [Similar Products]
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 NCBI Official Full Name    GATA6 protein
 NCBI Official Synonym Full Names    GATA binding protein 6
 NCBI Official Symbol    GATA6 [Similar Products]
 NCBI Protein Information    transcription factor GATA-6; OTTHUMP00000162571; GATA-binding factor 6; GATA-binding protein 6
 UniProt Protein Name    GATA6 protein
 Protein Family    GATA transcription factor
 UniProt Gene Name    GATA6 [Similar Products]
 UniProt Entry Name    Q05CA6_HUMAN
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 NCBI Summary for GATA6    This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
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 UniProt Comments for GATA6    GATA6: Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 18q11.1-q11.2

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; zinc ion binding; chromatin binding; transcription factor activity; transcription factor binding; protein kinase binding

Biological Process: cardiac muscle hypertrophy; response to drug; transcription from RNA polymerase II promoter; endodermal cell fate determination; organ formation; in utero embryonic development; male gonad development; negative regulation of transcription from RNA polymerase II promoter; liver development; cardiac muscle cell differentiation; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; response to estrogen stimulus; phospholipid metabolic process; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; tube morphogenesis; blood coagulation; negative regulation of transcription, DNA-dependent; positive regulation of cardiac muscle cell proliferation; negative regulation of apoptosis

Disease: Atrial Septal Defect 9; Conotruncal Heart Malformations; Heart Defects, Congenital, And Other Congenital Anomalies; Tetralogy Of Fallot; Atrioventricular Septal Defect 5
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 Research Articles on GATA6    1. GATA6 plays a crucial role for endothelial cell function and survival, at least in part, by suppressing autocrine TGFbeta expression and ALK5-dependent signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GATA6 antibodyPathways associated with anti-GATA6 antibody
 Reference Product  PubMed Publications
 HHEX antibody  >4 publications with GATA6 and HHEX
 NKX2-1 antibody  >3 publications with GATA6 and NKX2-1
 MED1 antibody  >2 publications with GATA6 and MED1
 EP300 antibody  >2 publications with GATA6 and EP300
 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
Diseases associated with anti-GATA6 antibodyOrgans/Tissues associated with anti-GATA6 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >74 publications with GATA6 and Neoplasms
 Carcinoma Antibodies  >42 publications with GATA6 and Carcinoma
 Cardiovascular Diseases Antibodies  >30 publications with GATA6 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >23 publications with GATA6 and Adenocarcinoma
 Gonadal Disorders Antibodies  >17 publications with GATA6 and Gonadal Disorders
 Congenital Abnormalities Antibodies  >15 publications with GATA6 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >14 publications with GATA6 and Heart Defects, Congenital
 Embryo Loss Antibodies  >14 publications with GATA6 and Embryo Loss
 Ovarian Neoplasms Antibodies  >13 publications with GATA6 and Ovarian Neoplasms
 Genital Neoplasms, Female Antibodies  >12 publications with GATA6 and Genital Neoplasms, Female
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >98 publications with GATA6 and Heart
 Embryonic Tissue Antibodies  >84 publications with GATA6 and Embryonic Tissue
 Lung Antibodies  >46 publications with GATA6 and Lung
 Vascular Antibodies  >43 publications with GATA6 and Vascular
 Liver Antibodies  >32 publications with GATA6 and Liver
 Intestine Antibodies  >25 publications with GATA6 and Intestine
 Ovary Antibodies  >22 publications with GATA6 and Ovary
 Stomach Antibodies  >19 publications with GATA6 and Stomach
 Adrenal Gland Antibodies  >14 publications with GATA6 and Adrenal Gland
 Pancreas Antibodies  >12 publications with GATA6 and Pancreas
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