NP_001483.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
embryonic growth/differentiation factor 1
NCBI Official Synonym Full Names
growth differentiation factor 1
NCBI Protein Information
embryonic growth/differentiation factor 1
UniProt Protein Name
Embryonic growth/differentiation factor 1
UniProt Synonym Gene Names
NCBI Summary for GDF-1
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016]
UniProt Comments for GDF-1
May mediate cell differentiation events during embryonic development.
Research Articles on GDF-1
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Products associated with anti-GDF-1 antibody
Pathways associated with anti-GDF-1 antibody
Diseases associated with anti-GDF-1 antibody
Organs/Tissues associated with anti-GDF-1 antibody
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