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anti-GDF1 antibody :: Rabbit GDF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS153398
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDF1, Polyclonal Antibody

 Also Known As   

GDF1 Antibody

 Product Synonym Names    GDF1; RAI; DORV; DTGA3GDF-1; growth differentiation factor 1
 Product Gene Name   

anti-GDF1 antibody

[Similar Products]
 Antibody/Peptide Pairs    GDF1 peptide (MBS154089) is used for blocking the activity of GDF1 antibody (MBS153398)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613854
 3D Structure    ModBase 3D Structure for P27539
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    GDF1 antibody is predicted to not cross-react with any other members of the growth differentiation factor family.
 Purity/Purification    GDF1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    Rabbit polyclonal GDF1 antibody was raised against a 16 amino acid peptide near the amino terminus of human GDF1.
 Buffer    GDF1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    GDF1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-GDF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GDF1 antibody

   GDF1 Antibody: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. GDF1 was initially identified as a temporally expressed gene in the mouse central nervous system during embryonic development, with only one isoform detected in adult tissues. GDF1 is required for left-right patterning during development and directly interacts with Nodal, another member of the TGF-beta superfamily. It has been suggested that GDF1 regulates the activity and signaling range of Nodal through direct interaction.
 Applications Tested/Suitable for anti-GDF1 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-GDF1 antibody    GDF1 antibody can be used for detection of GDF1 by Western blot at 1 - 2 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-GDF1 antibody    Western blot analysis of GDF1 in rat lung tissue lysate with GDF1 antibody at (A) 1 and (B) 2 μg/mL.
anti-GDF1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-GDF1 antibody    Immunofluorescence of GDF1 in human lung tissue with GDF1 antibody at 20 μg/mL.
anti-GDF1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for GDF1. It may not necessarily be applicable to this product.
 NCBI GI #    110349792
 NCBI GeneID    2657
 NCBI Accession #    NP_001483 [Other Products]
 NCBI GenBank Nucleotide #    NM_001492.5 [Other Products]
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 UniProt Primary Accession #    P27539 [Other Products]
 UniProt Secondary Accession #    O43344 [Other Products]
 UniProt Related Accession #    P27539 [Other Products]
 Molecular Weight    41 kDa
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 NCBI Official Full Name    embryonic growth/differentiation factor 1
 NCBI Official Synonym Full Names    growth differentiation factor 1
 NCBI Official Symbol    GDF1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    embryonic growth/differentiation factor 1; GDF-1
 UniProt Protein Name    Embryonic growth/differentiation factor 1
 Protein Family    Embryonic growth/differentiation factor
 UniProt Gene Name    GDF1 [Similar Products]
 UniProt Synonym Gene Names    GDF-1 [Similar Products]
 UniProt Entry Name    GDF1_HUMAN
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 NCBI Summary for GDF1    This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Mar 2014]
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 UniProt Comments for GDF1    GDF1: May mediate cell differentiation events during embryonic development. Defects in GDF1 are a cause of conotruncal heart malformations (CTHM). A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Defects in GDF1 are the cause of transposition of the great arteries dextro-looped type 3 (DTGA3). A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries. Defects in GDF1 are a cause of tetralogy of Fallot (TOF). A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; BMP signaling pathway; regulation of MAPKKK cascade; cell development; growth

Disease: Transposition Of The Great Arteries, Dextro-looped 3; Right Atrial Isomerism; Conotruncal Heart Malformations; Tetralogy Of Fallot
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 Research Articles on GDF1    1. This implies that Gdf1 potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GDF1 antibodyPathways associated with anti-GDF1 antibody
 Reference Product  PubMed Publications
 CFC1 antibody  >6 publications with GDF1 and CFC1
 FOXH1 antibody  >3 publications with GDF1 and FOXH1
 SMAD2 antibody  >3 publications with GDF1 and SMAD2
 IHH antibody  >2 publications with GDF1 and IHH
 ACVR1C antibody  >1 publications with GDF1 and ACVR1C
 LASS1 antibody  >1 publications with GDF1 and LASS1
 MED13L antibody  >1 publications with GDF1 and MED13L
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
Diseases associated with anti-GDF1 antibodyOrgans/Tissues associated with anti-GDF1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >8 publications with GDF1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >8 publications with GDF1 and Heart Diseases
 Transposition of Great Vessels Antibodies  >3 publications with GDF1 and Transposition of Great Vessels
 Genital Diseases, Male Antibodies  >2 publications with GDF1 and Genital Diseases, Male
 Prostatic Diseases Antibodies  >2 publications with GDF1 and Prostatic Diseases
 Tetralogy of Fallot Antibodies  >2 publications with GDF1 and Tetralogy of Fallot
 Hypertrophy Antibodies  >1 publications with GDF1 and Hypertrophy
 Edema Antibodies  >1 publications with GDF1 and Edema
 Double Outlet Right Ventricle Antibodies  >1 publications with GDF1 and Double Outlet Right Ventricle
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >8 publications with GDF1 and Nerve
 Embryonic Tissue Antibodies  >7 publications with GDF1 and Embryonic Tissue
 Brain Antibodies  >6 publications with GDF1 and Brain
 Muscle Antibodies  >5 publications with GDF1 and Muscle
 Lung Antibodies  >2 publications with GDF1 and Lung
 Testis Antibodies  >1 publications with GDF1 and Testis
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