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| Product Name
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GDF15, Polyclonal Antibody
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| Also Known As
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Goat Polyclonal to Human GDF15
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| Product Synonym Names
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Anti-GDF15 Antibody (C-Terminus) IHC-plus; GDF15; MIC1; MIC-1; NAG-1; NRG-1; NSAID-regulated gene 1 protein; PLAB; NSAID-activated gene 1 protein; Placental TGF-beta; PTGFB; GDF-15; PTGF-beta; Human GDF15
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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605312
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| 3D Structure
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ModBase 3D Structure for Q99988
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| Clonality
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Polyclonal
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| Host
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Goat
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| Species Reactivity
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Gibbon, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
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| Specificity
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Human GDF15.
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| Purity/Purification
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Immunoaffinity Purified
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| Form/Format
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Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
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| Concentration
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0.5 mg/ml (lot specific)
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| Target Species
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Human
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| Immunogen Description
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Synthetic peptide C-QKTDTGVSLQTYDD from the C-terminus of human GDF15 (NP_004855.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset (93%).
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| Immunogen Type
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Synthetic peptide
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| Immunogen
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GDF15 antibody was raised against synthetic peptide C-QKTDTGVSLQTYDD from the C-terminus of human GDF15 (NP_004855.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset (93%).
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| Antigen Modification
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C-Terminus
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| Preparation and Storage
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Store at -20 degree C. Minimize freezing and thawing.
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| Other Notes
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Small volumes of anti-GDF15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB. GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues.
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| Product Categories/Family for anti-GDF15 antibody
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Family: TGF beta
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| Applications Tested/Suitable for anti-GDF15 antibody
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Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
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| Application Notes for anti-GDF15 antibody
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ELISA (1:2000), IHC-P (5 ug/ml), WB (0.1 - 0.3 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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| Immunohistochemistry (IHC) of anti-GDF15 antibody
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Anti-GDF15 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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| Immunohistochemistry (IHC) of anti-GDF15 antibody
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Anti-GDF15 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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| Western Blot (WB) of anti-GDF15 antibody
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Antibody (0.1 ug/ml) staining of Human Prostate lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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TOP
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| NCBI/Uniprot data below describe general gene information for GDF15. It may not necessarily be applicable to this product. |
| NCBI GI #
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153792495
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| NCBI GeneID
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9518
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| NCBI Accession #
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NP_004855.2
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_004864.2
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[Other Products]
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| UniProt Primary Accession #
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Q99988
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[Other Products]
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| UniProt Secondary Accession #
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O14629; P78360; Q9BWA0; Q9NRT0
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[Other Products]
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| UniProt Related Accession #
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Q99988
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[Other Products]
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| Molecular Weight
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34,140 Da
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TOP
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| NCBI Official Full Name
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growth/differentiation factor 15
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| NCBI Official Synonym Full Names
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growth differentiation factor 15
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| NCBI Official Symbol
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GDF15
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[Similar Products]
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| NCBI Official Synonym Symbols
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PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
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[Similar Products]
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| NCBI Protein Information
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growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
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| UniProt Protein Name
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Growth/differentiation factor 15
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| UniProt Synonym Protein Names
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Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
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| Protein Family
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Growth/differentiation factor
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| UniProt Gene Name
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GDF15
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[Similar Products]
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| UniProt Synonym Gene Names
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MIC1; PDF; PLAB; PTGFB; GDF-15; MIC-1; NAG-1; NRG-1
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[Similar Products]
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| UniProt Entry Name
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GDF15_HUMAN
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| NCBI Summary for GDF15
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Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]
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| UniProt Comments for GDF15
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GDF15: disulfide-linked. Belongs to the TGF-beta family.
Protein type: Cytokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: extracellular space; extracellular region
Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding
Biological Process: regulation of apoptosis; cell-cell signaling; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; signal transduction; cell development
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TOP
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| Research Articles on GDF15
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1. Suggest that GDF-15 might be a useful biomarker for discriminating hypertrophic cardiomyopathy from left ventricular hypertrophy.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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TOP
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| Products associated with anti-GDF15 antibody | Pathways associated with anti-GDF15 antibody |
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| Diseases associated with anti-GDF15 antibody | Organs/Tissues associated with anti-GDF15 antibody |
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TOP
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Antibody 
