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anti-GDF15 antibody :: Goat GDF15 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242035
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDF15, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human GDF15

 Product Synonym Names    Anti-GDF15 Antibody (C-Terminus) IHC-plus; GDF15; MIC1; MIC-1; NAG-1; NRG-1; NSAID-regulated gene 1 protein; PLAB; NSAID-activated gene 1 protein; Placental TGF-beta; PTGFB; GDF-15; PTGF-beta; Human GDF15
 Product Gene Name   

anti-GDF15 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605312
 3D Structure    ModBase 3D Structure for Q99988
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Gibbon, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
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 Specificity    Human GDF15.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-QKTDTGVSLQTYDD from the C-terminus of human GDF15 (NP_004855.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset (93%).
 Immunogen Type    Synthetic peptide
 Immunogen    GDF15 antibody was raised against synthetic peptide C-QKTDTGVSLQTYDD from the C-terminus of human GDF15 (NP_004855.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset (93%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-GDF15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GDF15 antibody

   Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB. GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues.
 Product Categories/Family for anti-GDF15 antibody    Family: TGF beta
 Applications Tested/Suitable for anti-GDF15 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-GDF15 antibody    ELISA (1:2000), IHC-P (5 ug/ml), WB (0.1 - 0.3 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-GDF15 antibody    Anti-GDF15 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-GDF15 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GDF15 antibody    Anti-GDF15 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-GDF15 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-GDF15 antibody    Antibody (0.1 ug/ml) staining of Human Prostate lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GDF15 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GDF15. It may not necessarily be applicable to this product.
 NCBI GI #    153792495
 NCBI GeneID    9518
 NCBI Accession #    NP_004855.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004864.2 [Other Products]
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 UniProt Primary Accession #    Q99988 [Other Products]
 UniProt Secondary Accession #    O14629; P78360; Q9BWA0; Q9NRT0 [Other Products]
 UniProt Related Accession #    Q99988 [Other Products]
 Molecular Weight    34,140 Da
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 NCBI Official Full Name    growth/differentiation factor 15
 NCBI Official Synonym Full Names    growth differentiation factor 15
 NCBI Official Symbol    GDF15 [Similar Products]
 NCBI Official Synonym Symbols   
PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
 UniProt Protein Name    Growth/differentiation factor 15
 UniProt Synonym Protein Names   
Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
 Protein Family    Growth/differentiation factor
 UniProt Gene Name    GDF15 [Similar Products]
 UniProt Synonym Gene Names    MIC1; PDF; PLAB; PTGFB; GDF-15; MIC-1; NAG-1; NRG-1 [Similar Products]
 UniProt Entry Name    GDF15_HUMAN
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 NCBI Summary for GDF15    Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]
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 UniProt Comments for GDF15    GDF15: disulfide-linked. Belongs to the TGF-beta family.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; cell-cell signaling; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; signal transduction; cell development
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 Research Articles on GDF15    1. Suggest that GDF-15 might be a useful biomarker for discriminating hypertrophic cardiomyopathy from left ventricular hypertrophy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GDF15 antibodyPathways associated with anti-GDF15 antibody
 Reference Product  PubMed Publications
 HAMP antibody  >46 publications with GDF15 and HAMP
 TNF antibody  >21 publications with GDF15 and TNF
 ATF3 antibody  >19 publications with GDF15 and ATF3
 TP53 antibody  >11 publications with GDF15 and TP53
 PDF antibody  >9 publications with GDF15 and PDF
 HIF1A antibody  >8 publications with GDF15 and HIF1A
 FOS antibody  >8 publications with GDF15 and FOS
 AKT1 antibody  >6 publications with GDF15 and AKT1
 CA2 antibody  >1 publications with GDF15 and CA2
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
Diseases associated with anti-GDF15 antibodyOrgans/Tissues associated with anti-GDF15 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >119 publications with GDF15 and Heart Diseases
 Inflammation Antibodies  >82 publications with GDF15 and Inflammation
 Gastrointestinal Neoplasms Antibodies  >62 publications with GDF15 and Gastrointestinal Neoplasms
 Heart Failure Antibodies  >61 publications with GDF15 and Heart Failure
 Anemia Antibodies  >57 publications with GDF15 and Anemia
 Myocardial Ischemia Antibodies  >55 publications with GDF15 and Myocardial Ischemia
 Prostatic Neoplasms Antibodies  >50 publications with GDF15 and Prostatic Neoplasms
 Necrosis Antibodies  >41 publications with GDF15 and Necrosis
 Adenocarcinoma Antibodies  >32 publications with GDF15 and Adenocarcinoma
 Brain Diseases Antibodies  >31 publications with GDF15 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >275 publications with GDF15 and Blood
 Heart Antibodies  >119 publications with GDF15 and Heart
 Bone Antibodies  >82 publications with GDF15 and Bone
 Prostate Antibodies  >72 publications with GDF15 and Prostate
 Brain Antibodies  >72 publications with GDF15 and Brain
 Vascular Antibodies  >50 publications with GDF15 and Vascular
 Liver Antibodies  >44 publications with GDF15 and Liver
 Lung Antibodies  >39 publications with GDF15 and Lung
 Kidney Antibodies  >32 publications with GDF15 and Kidney
 Muscle Antibodies  >30 publications with GDF15 and Muscle
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