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anti-GDF5 antibody :: Rabbit anti-Human GDF5 / GDF-5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241025
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDF5 / GDF-5, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human GDF5 / GDF-5

 Product Synonym Names    Anti-GDF5 / GDF-5 Antibody (aa28-41) IHC-plus; GDF5; CDMP-1; CDMP1; GDF-5; LAP4; Radotermin; OS5; BMP14; SYNS2; Human GDF5; GDF-5
 Product Gene Name   

anti-GDF5 antibody

[Similar Products]
 Product Synonym Gene Name    GDF-5 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 615298
 3D Structure    ModBase 3D Structure for P43026
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Amino acids 28 to 41 of human GDF5
 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human GDF5.
 Immunogen Type    Synthetic peptide
 Immunogen    GDF5 / GDF-5 antibody was raised against synthetic peptide from human GDF5.
 Antigen Modification    aa28-41
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-GDF5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GDF5 antibody

   The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues.
 Product Categories/Family for anti-GDF5 antibody    Family: TGF beta
 Applications Tested/Suitable for anti-GDF5 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-GDF5 antibody    ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-GDF5 antibody    Anti-GDF5 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-GDF5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GDF5. It may not necessarily be applicable to this product.
 NCBI GI #    4503969
 NCBI GeneID    8200
 NCBI Accession #    NP_000548.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000557.3 [Other Products]
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 UniProt Primary Accession #    P43026 [Other Products]
 UniProt Secondary Accession #    Q96SB1; E1P5Q2 [Other Products]
 UniProt Related Accession #    P43026 [Other Products]
 Molecular Weight    55,411 Da
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 NCBI Official Full Name    growth/differentiation factor 5 preproprotein
 NCBI Official Synonym Full Names    growth differentiation factor 5
 NCBI Official Symbol    GDF5 [Similar Products]
 NCBI Official Synonym Symbols   
OS5; LAP4; BDA1C; BMP14; CDMP1; LAP-4; SYM1B; SYNS2; BMP-14
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 5; CDMP-1; radotermin; LPS-associated protein 4; bone morphogenetic protein 14; lipopolysaccharide-associated protein 4; cartilage-derived morphogenetic protein-1
 UniProt Protein Name    Growth/differentiation factor 5
 UniProt Synonym Protein Names   
Bone morphogenetic protein 14; BMP-14; Cartilage-derived morphogenetic protein 1; CDMP-1; Lipopolysaccharide-associated protein 4; LAP-4; LPS-associated protein 4; Radotermin
 Protein Family    Growth/differentiation factor
 UniProt Gene Name    GDF5 [Similar Products]
 UniProt Synonym Gene Names    BMP14; CDMP1; GDF-5; BMP-14; CDMP-1; LAP-4; LPS-associated protein 4 [Similar Products]
 UniProt Entry Name    GDF5_HUMAN
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 NCBI Summary for GDF5    The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GDF5    GDF5: a cytokine that is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. These cytokines are characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Binds to bone morphogenetic protein receptors (BMPRs), a family of transmembrane serine/threonine kinases. BMPRs are involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Defects in GDF5 are the cause of acromesomelic chondrodysplasia Grebe type (AMDG), acromesomelic chondrodysplasia Hunter-Thompson type (AMDH), brachydactyly type C (BDC), Du Pan syndrome (DPS), symphalangism proximal syndrome (SYM1), multiple synostoses syndrome type 2 (SYNS2), and brachydactyly type A2 (BDA2). Genetic variations in GDF5 are associated with susceptibility to osteoarthritis type 5 (OS5). Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: extracellular space; plasma membrane; extracellular region

Molecular Function: identical protein binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: hindlimb morphogenesis; extracellular matrix organization and biogenesis; regulation of multicellular organism growth; BMP signaling pathway; regulation of apoptosis; forelimb morphogenesis; positive regulation of chondrocyte differentiation; cell-cell signaling; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; chondrocyte differentiation; negative regulation of neuron apoptosis; positive regulation of neuron differentiation; cell development; growth; negative regulation of epithelial cell proliferation; embryonic limb morphogenesis

Disease: Chondrodysplasia, Grebe Type; Acromesomelic Dysplasia, Hunter-thompson Type; Brachydactyly, Type A1, C; Brachydactyly, Type A2; Symphalangism, Proximal, 1b; Brachydactyly, Type C; Fibular Hypoplasia And Complex Brachydactyly; Osteoarthritis Susceptibility 5; Multiple Synostoses Syndrome 2
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 Research Articles on GDF5    1. Growth differentiation factor 5 and canonical Wnt signaling may contribute to molecular mechanisms of osteoarthritis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GDF5 antibodyPathways associated with anti-GDF5 antibody
 Reference Product  PubMed Publications
 BMPR1A antibody  >40 publications with GDF5 and BMPR1A
 BMPR2 antibody  >26 publications with GDF5 and BMPR2
 BMPR1B antibody  >23 publications with GDF5 and BMPR1B
 NOG antibody  >14 publications with GDF5 and NOG
 RUNX2 antibody  >10 publications with GDF5 and RUNX2
 COL1A1 antibody  >8 publications with GDF5 and COL1A1
 SMAD5 antibody  >7 publications with GDF5 and SMAD5
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Molecules Associated With Elastic Fibres Pathway antibodies  Molecules Associated With Elastic Fibres Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with anti-GDF5 antibodyOrgans/Tissues associated with anti-GDF5 antibody
 Disease Name  Pubmed Publications
 Osteoarthritis Antibodies  >80 publications with GDF5 and Osteoarthritis
 Brachydactyly type C Antibodies  >15 publications with GDF5 and Brachydactyly type C
 Parkinson Disease Antibodies  >14 publications with GDF5 and Parkinson Disease
 Necrosis Antibodies  >14 publications with GDF5 and Necrosis
 Inflammation Antibodies  >13 publications with GDF5 and Inflammation
 Movement Disorders Antibodies  >11 publications with GDF5 and Movement Disorders
 Pain Antibodies  >11 publications with GDF5 and Pain
 Brain Diseases Antibodies  >11 publications with GDF5 and Brain Diseases
 Brachydactyly type A2 Antibodies  >9 publications with GDF5 and Brachydactyly type A2
 Fibrosis Antibodies  >6 publications with GDF5 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >407 publications with GDF5 and Bone
 Connective Tissue Antibodies  >101 publications with GDF5 and Connective Tissue
 Embryonic Tissue Antibodies  >52 publications with GDF5 and Embryonic Tissue
 Brain Antibodies  >26 publications with GDF5 and Brain
 Skin Antibodies  >19 publications with GDF5 and Skin
 Eye Antibodies  >10 publications with GDF5 and Eye
 Heart Antibodies  >9 publications with GDF5 and Heart
 Lung Antibodies  >5 publications with GDF5 and Lung
 Prostate Antibodies  >4 publications with GDF5 and Prostate
 Uterus Antibodies  >3 publications with GDF5 and Uterus
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