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anti-GDF6 antibody :: Rabbit GDF6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151210
Western Blot (WB)
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GDF6, Polyclonal Antibody

 Also Known As   

GDF6 Antibody

 Product Synonym Names    GDF6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; LCA17; MCOP4; SCDO4; MCOPCB6; GDF16GDF-6; growth differentiation factor 6
 Product Gene Name   

anti-GDF6 antibody

[Similar Products]
 Antibody/Peptide Pairs    GDF6 peptide (MBS152434) is used for blocking the activity of GDF6 antibody (MBS151210)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 615360
 3D Structure    ModBase 3D Structure for Q6KF10
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    GDF6 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    GDF6 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human GDF6.
 Buffer    GDF6 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    GDF6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-GDF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GDF6 antibody

   GDF6 Antibody: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.
 Applications Tested/Suitable for anti-GDF6 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-GDF6 antibody    GDF6 antibody can be used for detection of GDF6 by Western blot at 0.5 to 1 mug/mL.
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 Western Blot (WB) of anti-GDF6 antibody    Western blot analysis of GDF6 in SK-N-SH lysate with GDF6 antibody at (A) 0.5 and (B) 1 μg/mL.
anti-GDF6 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GDF6. It may not necessarily be applicable to this product.
 NCBI GI #    48475062
 NCBI GeneID    392255
 NCBI Accession #    NP_001001557 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001557.2 [Other Products]
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 UniProt Primary Accession #    Q6KF10 [Other Products]
 UniProt Secondary Accession #    Q6PI58 [Other Products]
 UniProt Related Accession #    Q6KF10 [Other Products]
 Molecular Weight    50,662 Da
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 NCBI Official Full Name    growth/differentiation factor 6
 NCBI Official Synonym Full Names    growth differentiation factor 6
 NCBI Official Symbol    GDF6 [Similar Products]
 NCBI Official Synonym Symbols   
KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; LCA17; MCOP4; SCDO4; BMP-13; MCOPCB6
[Similar Products]
 NCBI Protein Information    growth/differentiation factor 6; GDF-6; Klippel-Feil syndrome; Klip-Feil malformation; Klippel-Feil malformation; bone morphogenetic protein 13; growth/differentiation factor 16
 UniProt Protein Name    Growth/differentiation factor 6
 UniProt Synonym Protein Names   
Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16
 Protein Family    Growth/differentiation factor
 UniProt Gene Name    GDF6 [Similar Products]
 UniProt Synonym Gene Names    BMP13; GDF16; GDF-6; BMP-13 [Similar Products]
 UniProt Entry Name    GDF6_HUMAN
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 NCBI Summary for GDF6    This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GDF6    GDF6: Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Defects in GDF6 are the cause of Klippel-Feil syndrome type 1 (KFS1). A skeletal disorder characterized by congenital fusion of cervical vertebrae. It is due to a failure in the normal segmentation of vertebrae during the early weeks of fetal development. The clinical triad consists of short neck, low posterior hairline, and limited neck movement. Deafness is a well- known feature of KFS and may be of sensorineural, conductive, or mixed type. A chromosomal aberration involving GDF6 has been found in a patient with Klippel-Feil syndrome (KFS). Paracentric inv(8)(q22;2q23.3). Defects in GDF6 are the cause of microphthalmia isolated type 4 (MCOP4). A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Belongs to the TGF-beta family.

Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: extracellular space

Molecular Function: protein homodimerization activity; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; BMP signaling pathway; apoptosis; regulation of MAPKKK cascade; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; positive regulation of neuron differentiation; cell development; growth

Disease: Klippel-feil Syndrome 1, Autosomal Dominant; Microphthalmia, Isolated 4; Leber Congenital Amaurosis 17; Microphthalmia, Isolated, With Coloboma 6
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 Research Articles on GDF6    1. Deficiency of gdf6 results in photoreceptor degeneration, so demonstrating a connection between Gdf6 signaling and photoreceptor survival.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GDF6 antibodyPathways associated with anti-GDF6 antibody
 Reference Product  PubMed Publications
 RAX antibody  >6 publications with GDF6 and RAX
 BMPR2 antibody  >5 publications with GDF6 and BMPR2
 BMPR1A antibody  >2 publications with GDF6 and BMPR1A
 SMAD5 antibody  >1 publications with GDF6 and SMAD5
 Products by Pathway  Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with anti-GDF6 antibodyOrgans/Tissues associated with anti-GDF6 antibody
 Disease Name  Pubmed Publications
 Coloboma Antibodies  >7 publications with GDF6 and Coloboma
 Klippel-Feil Syndrome Antibodies  >6 publications with GDF6 and Klippel-Feil Syndrome
 Metaplasia Antibodies  >1 publications with GDF6 and Metaplasia
 Fibrosis Antibodies  >1 publications with GDF6 and Fibrosis
 Inflammation Antibodies  >1 publications with GDF6 and Inflammation
 Microphthalmia, Isolated 4 Antibodies  >1 publications with GDF6 and Microphthalmia, Isolated 4
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >46 publications with GDF6 and Bone
 Embryonic Tissue Antibodies  >6 publications with GDF6 and Embryonic Tissue
 Brain Antibodies  >2 publications with GDF6 and Brain
 Placenta Antibodies  >1 publications with GDF6 and Placenta
 Testis Antibodies  >1 publications with GDF6 and Testis
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