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anti-ARHGEF5 antibody :: Goat GEF5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420902
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GEF5 (ARHGEF5), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-GEF5 Antibody

 Product Synonym Names    GEF5; DKFZp686N1969; ARHGEF5; Rho guanine nucleotide exchange factor (GEF) 5; P60; TIM; TIM1; guanine nucleotide regulatory protein TIM; oncogene TIM rho guanine nucleotide exchange factor 5; transforming immortalized mammary oncogene; GEF5 antibody; DKFZp686N1969 antibody; ARHGEF5 antibody; Rho guanine nucleotide exchange factor (GEF) 5 antibody; P60 antibody; TIM antibody; TIM1 antibody; guanine nucleotide regulatory protein TIM antibody; oncogene TIM rho guanine nucleotide exchange factor 5 antibody; transforming immortalized mammary oncogene antibody
 Product Gene Name   

anti-ARHGEF5 antibody

[Similar Products]
 Product Synonym Gene Name    GEF5 [Similar Products]
 Antibody/Peptide Pairs    GEF5 peptide (MBS426638) is used for blocking the activity of GEF5 antibody (MBS420902)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DKEIDQNSQQ EE
 OMIM    600888
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DKEIDQNSQQEE, from the internal region of the protein sequence according to NP_005426.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ARHGEF5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ARHGEF5 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ARHGEF5 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 170kDa band observed in Human HeLa lysates (calculated MW of 177kDa according to NP_005426.2). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-ARHGEF5 antibody    (0.1ug/ml) staining of HeLa Lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ARHGEF5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ARHGEF5. It may not necessarily be applicable to this product.
 NCBI GI #    50959191
 NCBI GeneID    7984
 NCBI Accession #    NP_005426.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005435.3 [Other Products]
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 UniProt Secondary Accession #    Q6ZML7; A6NNJ2 [Other Products]
 UniProt Related Accession #    Q12774 [Other Products]
 Molecular Weight    60,056 Da
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 NCBI Official Full Name    rho guanine nucleotide exchange factor 5
 NCBI Official Synonym Full Names    Rho guanine nucleotide exchange factor 5
 NCBI Official Symbol    ARHGEF5 [Similar Products]
 NCBI Official Synonym Symbols   
P60; TIM; GEF5; TIM1
[Similar Products]
 NCBI Protein Information    rho guanine nucleotide exchange factor 5
 UniProt Protein Name    Rho guanine nucleotide exchange factor 5
 UniProt Synonym Protein Names   
Ephexin-3; Guanine nucleotide regulatory protein TIM; Oncogene TIM; Transforming immortalized mammary oncogene; p60 TIM
 Protein Family    Rho guanine nucleotide exchange factor
 UniProt Gene Name    ARHGEF5 [Similar Products]
 UniProt Synonym Gene Names    TIM [Similar Products]
 UniProt Entry Name    ARHG5_HUMAN
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 NCBI Summary for ARHGEF5    Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ARHGEF5    ARHGEF5: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; Motility/polarity/chemotaxis; Oncoprotein; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: cell junction; cell projection; cytoplasm; nucleoplasm; nucleus; plasma membrane; podosome

Molecular Function: GTP binding; guanyl-nucleotide exchange factor activity; lipid binding; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: actin cytoskeleton organization and biogenesis; myeloid dendritic cell chemotaxis; positive regulation of GTPase activity; positive regulation of JNK activity; positive regulation of stress fiber formation; positive regulation of transcription factor activity; regulation of actin cytoskeleton organization and biogenesis; regulation of cytoskeleton organization and biogenesis; regulation of GTPase activity; regulation of Rho protein signal transduction
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 Research Articles on ARHGEF5    1. Data indicate that Rho guanine nucleotide exchange factor 5 (ARHGEF5) is expressed in most human lung adenocarcinoma tissues and cell lines.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ARHGEF5 antibodyDiseases associated with anti-ARHGEF5 antibody
 Products by Pathway  Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with ARHGEF5 and Breast Neoplasms
 Adenocarcinoma Antibodies  >1 publications with ARHGEF5 and Adenocarcinoma
 Seizures Antibodies  >1 publications with ARHGEF5 and Seizures
 Disease Models, Animal Antibodies  >1 publications with ARHGEF5 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >1 publications with ARHGEF5 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >1 publications with ARHGEF5 and Inflammation
Organs/Tissues associated with anti-ARHGEF5 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with ARHGEF5 and Brain
 Lung Antibodies  >2 publications with ARHGEF5 and Lung
 Bone Antibodies  >1 publications with ARHGEF5 and Bone
 Mouth Antibodies  >1 publications with ARHGEF5 and Mouth
 Bone Marrow Antibodies  >1 publications with ARHGEF5 and Bone Marrow
 Skin Antibodies  >1 publications with ARHGEF5 and Skin
 Kidney Antibodies  >1 publications with ARHGEF5 and Kidney
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