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anti-GFER antibody :: Rabbit anti-Human, Mouse GFER Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS968809
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GFER, Polyclonal Antibody

★Popular Item★
 Also Known As   

GFER Antibody

 Product Synonym Names    Augmenter of liver regeneration; hERV1; Hepatopoietin; GFER; ALR; HERV1; HPO
 Product Gene Name   

anti-GFER antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600924
 3D Structure    ModBase 3D Structure for P55789
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human FAD-linked sulfhydryl oxidase ALR protein(81-205aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-51257
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GFER antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GFER antibody

   Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
 Applications Tested/Suitable for anti-GFER antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-GFER antibody    Recommended dilution: WB:1:200-1000
IHC:1:20-1:200
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 Western Blot (WB) of anti-GFER antibody    Western blot
All lanes: GFER antibody at 3ug/ml+mouse liver tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 24,16 kDa
Observed band size: 23 kDa

anti-GFER antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GFER antibody    Immunohistochemistry of paraffin-embedded human testicle using MBS968809 at dilution 1:100
anti-GFER antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GFER antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS968809 at dilution 1:100
anti-GFER antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GFER. It may not necessarily be applicable to this product.
 NCBI GI #    54112432
 NCBI GeneID    2671
 NCBI Accession #    NP_005253.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005262.2 [Other Products]
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 UniProt Primary Accession #    P55789 [Other Products]
 UniProt Secondary Accession #    Q53YM6; Q8TAH6; Q9H290; Q9UK40 [Other Products]
 UniProt Related Accession #    P55789 [Other Products]
 Molecular Weight    15,029 Da
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 NCBI Official Full Name    FAD-linked sulfhydryl oxidase ALR
 NCBI Official Synonym Full Names    growth factor, augmenter of liver regeneration
 NCBI Official Symbol    GFER [Similar Products]
 NCBI Official Synonym Symbols   
ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1
[Similar Products]
 NCBI Protein Information    FAD-linked sulfhydryl oxidase ALR
 UniProt Protein Name    FAD-linked sulfhydryl oxidase ALR
 UniProt Synonym Protein Names   
Augmenter of liver regeneration; hERV1; Hepatopoietin
 Protein Family    FAD-linked sulfhydryl oxidase
 UniProt Gene Name    GFER [Similar Products]
 UniProt Synonym Gene Names    ALR; HERV1; HPO; hERV1 [Similar Products]
 UniProt Entry Name    ALR_HUMAN
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 NCBI Summary for GFER    The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GFER    GFER: Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs. Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD); also called combined mitochondrial complex deficiency. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Oxidoreductase; EC 1.8.3.2

Chromosomal Location of Human Ortholog: 16p13.3-p13.12

Cellular Component: cytoplasm; extracellular region; mitochondrial intermembrane space; mitochondrion

Molecular Function: FAD binding; growth factor activity; protein binding; protein disulfide oxidoreductase activity; thiol oxidase activity

Biological Process: cellular protein metabolic process; protein targeting to mitochondrion

Disease: Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay
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 Research Articles on GFER    1. ALR plays a protective role against hydrogen peroxide-induced oxidative stress in renal proximal tubule cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GFER antibodyPathways associated with anti-GFER antibody
 Reference Product  PubMed Publications
 COPS5 antibody  >2 publications with GFER and COPS5
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
Diseases associated with anti-GFER antibodyOrgans/Tissues associated with anti-GFER antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >26 publications with GFER and Liver Diseases
 Drug-Induced Liver Injury Antibodies  >7 publications with GFER and Drug-Induced Liver Injury
 Liver Neoplasms Antibodies  >7 publications with GFER and Liver Neoplasms
 Disease Models, Animal Antibodies  >6 publications with GFER and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >6 publications with GFER and Carcinoma, Hepatocellular
 Hepatitis Antibodies  >5 publications with GFER and Hepatitis
 Necrosis Antibodies  >4 publications with GFER and Necrosis
 Poisoning Antibodies  >4 publications with GFER and Poisoning
 Liver Cirrhosis Antibodies  >4 publications with GFER and Liver Cirrhosis
 Liver Failure, Acute Antibodies  >4 publications with GFER and Liver Failure, Acute
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >49 publications with GFER and Liver
 Blood Antibodies  >8 publications with GFER and Blood
 Kidney Antibodies  >4 publications with GFER and Kidney
 Brain Antibodies  >4 publications with GFER and Brain
 Testis Antibodies  >2 publications with GFER and Testis
 Placenta Antibodies  >1 publications with GFER and Placenta
 Lung Antibodies  >1 publications with GFER and Lung
 Pituitary Gland Antibodies  >1 publications with GFER and Pituitary Gland
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