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anti-Gfra1 antibody :: Rabbit GFR alpha1, IN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS611148 anti-Gfra1 antibody
Unit / Price
0.1 mg  /  $510 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GFR alpha1, IN (Gfra1), Polyclonal Antibody

 Also Known As   

GFR alpha1, IN (GDNFRa, Glial Cell-derived Neurotrophic Factor Receptor a1, RETL1, Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1, Glycosylphosphadidylinositol linked Protein)

 Product Synonym Names    Anti -GFR alpha1, IN (GDNFRa, Glial Cell-derived Neurotrophic Factor Receptor a1, RETL1, Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1, Glycosylphosphadidylinositol linked Protein)
 Product Gene Name   

anti-Gfra1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_005100.2 (264614329..264875486, complement). Location: 1q55
 3D Structure    ModBase 3D Structure for Q62997
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes GDNFR alpha, a cell surface receptor for glial cell derived neutrophic factor (GDNF).GDNFR alpha has more recently been designated GFR alpha -1. Species Crossreactivity: Human, mouse, rat
 Purity/Purification    Highly Purified
Purified IgG prepared by ion exchange chromatography.
 Form/Format    Supplied as a liquid in PBS with 0.02% sodium azide.
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 Immunogen    Peptide from C terminus of human GDNFR alpha.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

 Other Notes    Small volumes of anti-Gfra1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Gfra1 antibody    Antibodies; Abs to Ligands
 Applications Tested/Suitable for anti-Gfra1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-Gfra1 antibody    Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:500-1:1000
Immunohistochemistry: paraffin; requires antigen retrieval with sodium citrate buffer, pH 6.0.
Optimal working dilutions to be determined by researcher.
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NCBI/Uniprot data below describe general gene information for Gfra1. It may not necessarily be applicable to this product.
 NCBI GI #    6978888
 NCBI GeneID    25454
 NCBI Accession #    NP_037091.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012959.1 [Other Products]
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 UniProt Primary Accession #    Q62997 [Other Products]
 UniProt Related Accession #    O35748; Q62997 [Other Products]
 Molecular Weight    51,650 Da [Similar Products]
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 NCBI Official Full Name    GDNF family receptor alpha-1
 NCBI Official Synonym Full Names    GDNF family receptor alpha 1
 NCBI Official Symbol    Gfra1 [Similar Products]
 NCBI Protein Information    GDNF family receptor alpha-1; GDNFR-alpha; GFR-alpha-1; RET ligand 1; GDNFR-alpha-1; GDNF receptor alpha; GDNF receptor alpha-1; TGF-beta-related neurotrophic factor receptor 1; Glial cell line-derived neurotrophic factor receptor alpha; glial cell line derived neurotrophic factor family receptor alpha 1
 UniProt Protein Name    GDNF family receptor alpha-1
 UniProt Synonym Protein Names   
RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
 Protein Family    GDNF family receptor
 UniProt Gene Name    Gfra1 [Similar Products]
 UniProt Synonym Gene Names    Gdnfra; Retl1; Trnr1 [Similar Products]
 UniProt Entry Name    GFRA1_RAT
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 NCBI Summary for Gfra1    binds glial cell line-derived neurotrophic factor (GDNF) and mediates Ret protein-tyrosine kinase receptor phosphorylation and activation [RGD]
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 UniProt Comments for Gfra1    GFRA1: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, GPI anchor

Cellular Component: extracellular space; cell soma; axon; plasma membrane; receptor complex; external side of plasma membrane

Molecular Function: integrin binding; protein binding; receptor activity

Biological Process: neuron differentiation; nervous system development; cell migration; male gonad development; kidney development; neurite development; aging
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 Research Articles on Gfra1    1. Post-synaptic striatal glial cell line-derived neurotrophic factor receptor-alpha1 expression effects the biology of dopamine neurons in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Gfra1 antibodyDiseases associated with anti-Gfra1 antibody
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >42 publications with Gfra1 and Neoplasms
 Central Nervous System Diseases Antibodies  >26 publications with Gfra1 and Central Nervous System Diseases
 Neuroectodermal Tumors Antibodies  >23 publications with Gfra1 and Neuroectodermal Tumors
 Carcinoma Antibodies  >19 publications with Gfra1 and Carcinoma
 Congenital Abnormalities Antibodies  >17 publications with Gfra1 and Congenital Abnormalities
 Intestinal Diseases Antibodies  >16 publications with Gfra1 and Intestinal Diseases
 Cardiovascular Diseases Antibodies  >12 publications with Gfra1 and Cardiovascular Diseases
 Thyroid Diseases Antibodies  >11 publications with Gfra1 and Thyroid Diseases
 Thyroid Neoplasms Antibodies  >10 publications with Gfra1 and Thyroid Neoplasms
 Adenocarcinoma Antibodies  >10 publications with Gfra1 and Adenocarcinoma
Organs/Tissues associated with anti-Gfra1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >87 publications with Gfra1 and Brain
 Kidney Antibodies  >28 publications with Gfra1 and Kidney
 Embryonic Tissue Antibodies  >28 publications with Gfra1 and Embryonic Tissue
 Dorsal Root Ganglion Antibodies  >23 publications with Gfra1 and Dorsal Root Ganglion
 Colon Antibodies  >3 publications with Gfra1 and Colon
 Pituitary Gland Antibodies  >2 publications with Gfra1 and Pituitary Gland
 Heart Antibodies  >2 publications with Gfra1 and Heart
 Spleen Antibodies  >1 publications with Gfra1 and Spleen
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