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anti-Gfra2 antibody :: Rabbit GFRa2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS615826 anti-Gfra2 antibody
Unit / Price
0.1 mg  /  $570 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GFRa2, Polyclonal Antibody

★Popular Item★
 Also Known As   

GFRa2 (GFRalpha2, Neurturin Receptor)

 Product Synonym Names    Anti -GFRa2 (GFRalpha2, Neurturin Receptor)
 Product Gene Name   

anti-Gfra2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000080.5 (71289937..71379645). Location: 14; 14 D3-E1
 3D Structure    ModBase 3D Structure for Q3UUD8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human GFRa2. Species Crossreactivity: mouse, rat.
 Purity/Purification    Highly Purified
Purified by ion exchange chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.02% sodium azide.
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 Immunogen    Synthetic peptide from C-terminus of human GFRa2.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-Gfra2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Gfra2 antibody

   Neurturin is a member of the GDNF family and has an important role in the control of vertebrate neuron survival and differentiation. GFRa2 is a receptor for neurturin. It mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It is also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GRFa2 is a 52kD glycoprotein and is a GPI-linked cell surface receptor.
 Product Categories/Family for anti-Gfra2 antibody    Antibodies; Abs to Growth Factors, Cytokines
 Applications Tested/Suitable for anti-Gfra2 antibody   

Western Blot (WB)

 Application Notes for anti-Gfra2 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000
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NCBI/Uniprot data below describe general gene information for Gfra2. It may not necessarily be applicable to this product.
 NCBI GI #    84662783
 NCBI GeneID    14586
 NCBI Accession #    NP_032141.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_008115.2 [Other Products]
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 UniProt Primary Accession #    Q3UUD8 [Other Products]
 UniProt Related Accession #    O08842; Q3UET6; Q3UUD8; Q920Y3; Q9Z2A2; Q9Z2A3 [Other Products]
 Molecular Weight    51,727 Da [Similar Products]
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 NCBI Official Full Name    GDNF family receptor alpha-2
 NCBI Official Synonym Full Names    glial cell line derived neurotrophic factor family receptor alpha 2
 NCBI Official Symbol    Gfra2 [Similar Products]
 NCBI Official Synonym Symbols   
Gfra2
[Similar Products]
 NCBI Protein Information    GDNF family receptor alpha-2; GDNFR-beta; NTNR-alpha; GFR alpha 2; GFR alpha-2; GFR-alpha-2; NRTNR-alpha; GDNFR-alpha-2; GDNF receptor beta; GDNF receptor alpha-2; neurturin receptor alpha; TGF-beta-related neurotrophic factor receptor 2
 UniProt Protein Name    Glial cell line derived neurotrophic factor family receptor alpha 2
 Protein Family    GDNF family receptor
 UniProt Gene Name    Gfra2 [Similar Products]
 UniProt Entry Name    Q3UUD8_MOUSE
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 NCBI Summary for Gfra2    The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
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 UniProt Comments for Gfra2    GFRA2: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Cellular Component: membrane; plasma membrane

Molecular Function: receptor activity; glial cell line-derived neurotrophic factor receptor activity

Biological Process: nervous system development; cytokine and chemokine mediated signaling pathway; negative regulation of protein amino acid autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on Gfra2    1. Increased apoptosis of parasympathetic but not enteric neurons in the developing pancreas of mice lacking GFRalpha2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-Gfra2 antibodyOrgans/Tissues associated with anti-Gfra2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with Gfra2 and Neoplasms
 Cardiovascular Diseases Antibodies  >5 publications with Gfra2 and Cardiovascular Diseases
 Thyroid Neoplasms Antibodies  >4 publications with Gfra2 and Thyroid Neoplasms
 Head and Neck Neoplasms Antibodies  >4 publications with Gfra2 and Head and Neck Neoplasms
 Pain Antibodies  >4 publications with Gfra2 and Pain
 Epilepsy Antibodies  >4 publications with Gfra2 and Epilepsy
 Intestinal Diseases Antibodies  >3 publications with Gfra2 and Intestinal Diseases
 Adenocarcinoma Antibodies  >3 publications with Gfra2 and Adenocarcinoma
 Schizophrenia Antibodies  >3 publications with Gfra2 and Schizophrenia
 Stroke Antibodies  >2 publications with Gfra2 and Stroke
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >46 publications with Gfra2 and Brain
 Embryonic Tissue Antibodies  >16 publications with Gfra2 and Embryonic Tissue
 Spinal Cord Antibodies  >12 publications with Gfra2 and Spinal Cord
 Eye Antibodies  >11 publications with Gfra2 and Eye
 Blood Antibodies  >8 publications with Gfra2 and Blood
 Sympathetic Ganglion Antibodies  >7 publications with Gfra2 and Sympathetic Ganglion
 Testis Antibodies  >2 publications with Gfra2 and Testis
 Thymus Antibodies  >1 publications with Gfra2 and Thymus
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