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anti-GHRL antibody :: Rabbit GHRL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126916
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GHRL, Polyclonal Antibody

 Also Known As   

GHRL Polyclonal Antibody

 Product Synonym Names    MTLRP; obestatin; GHRL
 Product Gene Name   

anti-GHRL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605353
 3D Structure    ModBase 3D Structure for Q9UBU3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human GHRL
 Calculated Molecular Weight    13kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-GHRL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GHRL antibody

   This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq, Oct 2008]
 Product Categories/Family for anti-GHRL antibody    Polyclonal
 Applications Tested/Suitable for anti-GHRL antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-GHRL antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-GHRL antibody    Western blot analysis of extracts of HeLa cell lines, using GHRL antibody.
anti-GHRL antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GHRL. It may not necessarily be applicable to this product.
 NCBI GI #    17865471
 NCBI GeneID    51738
 NCBI Accession #    Q9UBU3.1 [Other Products]
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 UniProt Primary Accession #    Q9UBU3 [Other Products]
 UniProt Secondary Accession #    Q86YP8; Q8TAT9; Q9H3R3; A8CF34; A8CF38; A8CF42; A8DN29; A8DN30 [Other Products]
 UniProt Related Accession #    Q9UBU3 [Other Products]
 Molecular Weight    117
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 NCBI Official Full Name    Appetite-regulating hormone
 NCBI Official Synonym Full Names    ghrelin/obestatin prepropeptide
 NCBI Official Symbol    GHRL [Similar Products]
 NCBI Official Synonym Symbols   
MTLRP
[Similar Products]
 NCBI Protein Information    appetite-regulating hormone; motilin-related peptide; ghrelin/obestatin preprohormone; growth hormone-releasing peptide; prepro-appetite regulatory hormone; ghrelin, growth hormone secretagogue receptor ligand
 UniProt Protein Name    Appetite-regulating hormone
 UniProt Synonym Protein Names   
Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46Cleaved into the following 3 chains:Ghrelin-27; Ghrelin-28; Ghrelin; Obestatin
 Protein Family    Ghrelin
 UniProt Gene Name    GHRL [Similar Products]
 UniProt Synonym Gene Names    MTLRP; Ghrelin [Similar Products]
 UniProt Entry Name    GHRL_HUMAN
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 NCBI Summary for GHRL    This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]
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 UniProt Comments for GHRL    ghrelin: a hormone that binds to the growth hormone secretagogue receptor type 1 (GHSR). Secreted by the stomach

Protein type: Secreted; Cell development/differentiation; Cell cycle regulation; Secreted, signal peptide; Apoptosis

Chromosomal Location of Human Ortholog: 3p26-p25

Cellular Component: extracellular space; endoplasmic reticulum lumen; axon; extracellular region

Molecular Function: growth hormone-releasing hormone activity; G-protein-coupled receptor binding; ghrelin receptor binding; protein tyrosine kinase activator activity

Biological Process: cortisol secretion; negative regulation of circadian sleep/wake cycle, REM sleep; positive regulation of cortisol secretion; hormone-mediated signaling; activation of MAPK activity; response to hormone stimulus; negative regulation of interleukin-6 biosynthetic process; positive regulation of multicellular organism growth; decidualization; positive regulation of adrenocorticotropic hormone secretion; negative regulation of insulin secretion; growth hormone secretion; elevation of cytosolic calcium ion concentration; negative regulation of locomotion; positive regulation of appetite; dendrite development; negative regulation of tumor necrosis factor biosynthetic process; positive regulation of circadian sleep/wake cycle, non-REM sleep; regulation of response to food; gastric acid secretion; positive regulation of insulin secretion; glucose metabolic process; adult feeding behavior; negative regulation of interleukin-1 beta production; regulation of cell proliferation; positive regulation of growth hormone secretion; positive regulation of synaptogenesis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; cellular protein metabolic process; response to estrogen stimulus; negative regulation of inflammatory response; cartilage development; actin polymerization and/or depolymerization; negative regulation of endothelial cell proliferation; regulation of excitatory postsynaptic membrane potential; negative regulation of apoptosis

Disease: Obesity
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 Research Articles on GHRL    1. Fasting plasma ghrelin levels were significantly lower in type 2 diabetes patients compared to controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GHRL antibodyPathways associated with anti-GHRL antibody
 Reference Product  PubMed Publications
 GHSR antibody  >28 publications with GHRL and GHSR
 NPY antibody  >12 publications with GHRL and NPY
 LEP antibody  >11 publications with GHRL and LEP
 CCK antibody  >5 publications with GHRL and CCK
 GHRH antibody  >3 publications with GHRL and GHRH
 AGRP antibody  >3 publications with GHRL and AGRP
 GCG antibody  >2 publications with GHRL and GCG
 IGF1 antibody  >1 publications with GHRL and IGF1
 GPR39 antibody  >1 publications with GHRL and GPR39
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
Diseases associated with anti-GHRL antibodyOrgans/Tissues associated with anti-GHRL antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >52 publications with GHRL and Obesity
 Insulin Resistance Antibodies  >18 publications with GHRL and Insulin Resistance
 Nervous System Diseases Antibodies  >13 publications with GHRL and Nervous System Diseases
 Weight Gain Antibodies  >12 publications with GHRL and Weight Gain
 Inflammation Antibodies  >10 publications with GHRL and Inflammation
 Cachexia Antibodies  >6 publications with GHRL and Cachexia
 Kidney Diseases Antibodies  >5 publications with GHRL and Kidney Diseases
 Heart Diseases Antibodies  >5 publications with GHRL and Heart Diseases
 Breast Neoplasms Antibodies  >5 publications with GHRL and Breast Neoplasms
 Necrosis Antibodies  >5 publications with GHRL and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >78 publications with GHRL and Blood
 Stomach Antibodies  >27 publications with GHRL and Stomach
 Brain Antibodies  >23 publications with GHRL and Brain
 Connective Tissue Antibodies  >11 publications with GHRL and Connective Tissue
 Intestine Antibodies  >4 publications with GHRL and Intestine
 Prostate Antibodies  >2 publications with GHRL and Prostate
 Embryonic Tissue Antibodies  >1 publications with GHRL and Embryonic Tissue
 Lung Antibodies  >1 publications with GHRL and Lung
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