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anti-GIPC1 antibody :: Goat GIPC1/NIP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421016
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GIPC1/NIP, Polyclonal Antibody

 Also Known As   

Goat anti-GIPC1/NIP Antibody

 Product Synonym Names    GIPC1; NIP; GIPC PDZ domain containing family, member 1; C19orf3; GIPC; GLUT1CBP; Hs. 6454; IIP-1; MGC15889; MGC3774; RGS19IP1; SEMCAP; SYNECTIIN; TIP-2; GLUT1 C-terminal binding protein; IGF-1 receptor interacting protein 1; regulator of G-protein signall; GIPC1 antibody; NIP antibody; GIPC PDZ domain containing family; member 1 antibody; C19orf3 antibody; GIPC antibody; GLUT1CBP antibody; Hs. 6454 antibody; IIP-1 antibody; MGC15889 antibody; MGC3774 antibody; RGS19IP1 antibody; SEMCAP antibody; SYNECTIIN antibody; TIP-2 antibody; GLUT1 C-terminal binding protein antibody; IGF-1 receptor interacting protein 1 antibody; regulator of G-protein signalling 19 interacting protein 1 antibody; synectin antibody; SYNECTIN antibody; GIPC1 / NIP
 Product Gene Name   

anti-GIPC1 antibody

[Similar Products]
 Product Synonym Gene Name    NIP [Similar Products]
 Antibody/Peptide Pairs    GIPC1 / NIP peptide (MBS426031) is used for blocking the activity of GIPC1/NIP antibody (MBS421016)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    GAIGDAKVGR Y
 OMIM    605072
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-GAIGDAKVGRY, from the C Terminus of the protein sequence according to NP_005707.1; NP_974197.1; NP_974199.1; NP_974196.1; NP_974198.1; NP_974223.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognize both isoform 1 (NP_005707.1, NP_974197.1 and NP_974199.1) and isoform 2 (NP_974196.1, NP_974198.1 and NP_974223.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GIPC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GIPC1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-GIPC1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 38kDa and strong 23-24kDa bands observed in lysates of cell line HeLa, and approx 24kDa also observed in Human Pancreas, Kidney and Muscle lysates (calculated MW of 36. 0kDa according to NP_005707.1, NP_974197.1 and NP_974199.1 and 26.1kDa according to NP_974198.1 and NP_974223.1). In transfected HEK293 transiently expressing GIPC1 isoform 1 a band of approx. 40kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 0. 03-0.1ug/ml.
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 Western Blot (WB) of anti-GIPC1 antibody    Staining (0. 03ug/ml) of human HeLa cell lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-GIPC1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-GIPC1 antibody    HEK293 overexpressing GIPC1 isoform 1 (RC216466) and probed (mock transfection in first lane), tested by Origene.
anti-GIPC1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GIPC1. It may not necessarily be applicable to this product.
 NCBI GI #    5031715
 NCBI GeneID    10755
 NCBI Accession #    NP_005707.1 [Other Products]
 NCBI Related Accession #    NP_974197.1; NP_974199.1; NP_974196.1; NP_974198.1; NP_974223.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005716.3 [Other Products]
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 UniProt Secondary Accession #    Q9BTC9; A8K4I3; A8MZG3 [Other Products]
 UniProt Related Accession #    O14908 [Other Products]
 Molecular Weight    26,072 Da
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 NCBI Official Full Name    PDZ domain-containing protein GIPC1 isoform 1
 NCBI Official Synonym Full Names    GIPC PDZ domain containing family member 1
 NCBI Official Symbol    GIPC1 [Similar Products]
 NCBI Official Synonym Symbols   
NIP; GIPC; IIP-1; TIP-2; SEMCAP; C19orf3; Hs.6454; GLUT1CBP; RGS19IP1; SYNECTIN; SYNECTIIN
[Similar Products]
 NCBI Protein Information    PDZ domain-containing protein GIPC1
 UniProt Protein Name    PDZ domain-containing protein GIPC1
 UniProt Synonym Protein Names   
GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Synectin; Tax interaction protein 2; TIP-2
 Protein Family    PDZ domain-containing protein
 UniProt Gene Name    GIPC1 [Similar Products]
 UniProt Synonym Gene Names    C19orf3; GIPC; RGS19IP1; TIP-2 [Similar Products]
 UniProt Entry Name    GIPC1_HUMAN
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 NCBI Summary for GIPC1    GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
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 UniProt Comments for GIPC1    GIPC1: May be involved in G protein-linked signaling. Belongs to the GIPC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; GAPs; GAPs, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: brush border; cell cortex; cytoplasm; cytoplasmic membrane-bound vesicle; cytosol; dendritic shaft; dendritic spine; endocytic vesicle; membrane; synaptic vesicle; vesicle membrane

Molecular Function: actin binding; myosin binding; PDZ domain binding; protein binding; protein homodimerization activity; receptor binding

Biological Process: endothelial cell migration; G-protein coupled receptor protein signaling pathway; glutamate secretion; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cytokinesis; positive regulation of transforming growth factor beta receptor signaling pathway; protein targeting; regulation of protein stability; regulation of synaptic plasticity; synaptic transmission
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 Research Articles on GIPC1    1. The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GIPC1 antibodyPathways associated with anti-GIPC1 antibody
 Reference Product  PubMed Publications
 RGS19 antibody  >8 publications with GIPC1 and RGS19
 IGF1R antibody  >5 publications with GIPC1 and IGF1R
 NRP1 antibody  >5 publications with GIPC1 and NRP1
 MYO6 antibody  >5 publications with GIPC1 and MYO6
 SLC2A1 antibody  >1 publications with GIPC1 and SLC2A1
 SDC4 antibody  >1 publications with GIPC1 and SDC4
 Products by Pathway  Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Syndecan-4-mediated Signaling Events Pathway antibodies  Syndecan-4-mediated Signaling Events Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with anti-GIPC1 antibodyOrgans/Tissues associated with anti-GIPC1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >16 publications with GIPC1 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >6 publications with GIPC1 and Ovarian Neoplasms
 Adenocarcinoma Antibodies  >4 publications with GIPC1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >3 publications with GIPC1 and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >2 publications with GIPC1 and Prostatic Neoplasms
 Heart Diseases Antibodies  >2 publications with GIPC1 and Heart Diseases
 Ataxia Antibodies  >2 publications with GIPC1 and Ataxia
 Nervous System Diseases Antibodies  >1 publications with GIPC1 and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with GIPC1 and Kidney Diseases
 Inflammation Antibodies  >1 publications with GIPC1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with GIPC1 and Lung
 Vascular Antibodies  >8 publications with GIPC1 and Vascular
 Brain Antibodies  >8 publications with GIPC1 and Brain
 Kidney Antibodies  >5 publications with GIPC1 and Kidney
 Heart Antibodies  >5 publications with GIPC1 and Heart
 Prostate Antibodies  >4 publications with GIPC1 and Prostate
 Muscle Antibodies  >3 publications with GIPC1 and Muscle
 Ovary Antibodies  >3 publications with GIPC1 and Ovary
 Intestine Antibodies  >2 publications with GIPC1 and Intestine
 Stomach Antibodies  >2 publications with GIPC1 and Stomach
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