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anti-GLI2 antibody :: Goat GLI2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421392 anti-GLI2 antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GLI2, Polyclonal Antibody

 Also Known As   

Goat anti-GLI2 Antibody

 Product Synonym Names    GLI2; GLI-Kruppel family member GLI2; THP2; oncogene GLI2; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; zinc finger protein GLI2; GLI2 antibody; GLI-Kruppel family member GLI2 antibody; THP2 antibody; oncogene GLI2 antibody; tax helper protein 2 antibody; tax-responsive element-2 holding protein antibody; tax-responsive element-25-bp sequence binding protein antibody; zinc finger protein GLI2 antibody
 Product Gene Name   

anti-GLI2 antibody

[Similar Products]
 Antibody/Peptide Pairs    GLI2 peptide (MBS425628) is used for blocking the activity of GLI2 antibody (MBS421392)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DLKEDLDRDD CKQE
 OMIM    165230
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence DLKEDLDRDDCKQE, from the internal region of the protein sequence according to NP_005261.2.
 Epitope    Internal region
 Note    This antibody is expected to recognise all four reported isoforms (NP_084655.1, NP_084656.1, NP_084657.1 and NP_005261.1)
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GLI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GLI2 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-GLI2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Preliminary experiments gave an approx 55kDa band in Human Bone Marrow and Ovary lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 168kDa according to NP_005261.2. The 55kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for GLI2. It may not necessarily be applicable to this product.
 NCBI GI #    86991432
 NCBI GeneID    2736
 NCBI Accession #    NP_005261.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005270.4 [Other Products]
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 UniProt Secondary Accession #    O60252; O60253; O60254; O60255; Q15590; Q15591; Q4JHT4 [Other Products]
 UniProt Related Accession #    P10070 [Other Products]
 Molecular Weight    86,482 Da
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 NCBI Official Full Name    zinc finger protein GLI2
 NCBI Official Synonym Full Names    GLI family zinc finger 2
 NCBI Official Symbol    GLI2 [Similar Products]
 NCBI Official Synonym Symbols   
CJS; HPE9; PHS2; THP1; THP2
[Similar Products]
 NCBI Protein Information    zinc finger protein GLI2
 UniProt Protein Name    Zinc finger protein GLI2
 UniProt Synonym Protein Names   
GLI family zinc finger protein 2
 Protein Family    Zinc finger protein
 UniProt Gene Name    GLI2 [Similar Products]
 UniProt Entry Name    GLI2_HUMAN
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 NCBI Summary for GLI2    This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GLI2    Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856).
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 Research Articles on GLI2    1. Identify mutations that increase GLI activity in patients with Hirschsprung disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GLI2 antibodyPathways associated with anti-GLI2 antibody
 Reference Product  PubMed Publications
 SHH antibody  >341 publications with GLI2 and SHH
 SMO antibody  >163 publications with GLI2 and SMO
 PTCH1 antibody  >113 publications with GLI2 and PTCH1
 SUFU antibody  >54 publications with GLI2 and SUFU
 IHH antibody  >53 publications with GLI2 and IHH
 SPOP antibody  >9 publications with GLI2 and SPOP
 PTCH2 antibody  >7 publications with GLI2 and PTCH2
 GSK3B antibody  >3 publications with GLI2 and GSK3B
 STK36 antibody  >2 publications with GLI2 and STK36
 PRKACA antibody  >1 publications with GLI2 and PRKACA
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Degradation Of GLI2 By The Proteasome Pathway antibodies  Degradation Of GLI2 By The Proteasome Pathway Diagram
 GLI Proteins Bind Promoters Of Hh Responsive Genes To Promote Transcription Pathway antibodies  GLI Proteins Bind Promoters Of Hh Responsive Genes To Promote Transcription Pathway Diagram
 Hedgehog 'off' State Pathway antibodies  Hedgehog 'off' State Pathway Diagram
 Hedgehog 'on' State Pathway antibodies  Hedgehog 'on' State Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
Diseases associated with anti-GLI2 antibodyOrgans/Tissues associated with anti-GLI2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >77 publications with GLI2 and Nervous System Diseases
 Carcinoma, Basal Cell Antibodies  >61 publications with GLI2 and Carcinoma, Basal Cell
 Abnormalities, Multiple Antibodies  >48 publications with GLI2 and Abnormalities, Multiple
 Skin Neoplasms Antibodies  >46 publications with GLI2 and Skin Neoplasms
 Adenocarcinoma Antibodies  >41 publications with GLI2 and Adenocarcinoma
 Nervous System Malformations Antibodies  >29 publications with GLI2 and Nervous System Malformations
 Disease Models, Animal Antibodies  >25 publications with GLI2 and Disease Models, Animal
 Liver Diseases Antibodies  >23 publications with GLI2 and Liver Diseases
 Fibrosis Antibodies  >23 publications with GLI2 and Fibrosis
 Lung Neoplasms Antibodies  >18 publications with GLI2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >133 publications with GLI2 and Embryonic Tissue
 Bone Antibodies  >103 publications with GLI2 and Bone
 Brain Antibodies  >103 publications with GLI2 and Brain
 Lung Antibodies  >48 publications with GLI2 and Lung
 Liver Antibodies  >40 publications with GLI2 and Liver
 Prostate Antibodies  >36 publications with GLI2 and Prostate
 Connective Tissue Antibodies  >21 publications with GLI2 and Connective Tissue
 Heart Antibodies  >16 publications with GLI2 and Heart
 Bone Marrow Antibodies  >14 publications with GLI2 and Bone Marrow
 Stomach Antibodies  >12 publications with GLI2 and Stomach
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