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anti-GLO1 antibody :: anti-Human, Mouse GLO1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127611
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GLO1, Polyclonal Antibody

★Popular Item★
 Also Known As   

GLO1 Polyclonal Antibody

 Product Synonym Names    GLYI; GLOD1; HEL-S-74
 Product Gene Name   

anti-GLO1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138750
 3D Structure    ModBase 3D Structure for Q04760
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 Clonality    Polyclonal
 Isotype    IgG
 Species Reactivity    Human, Mouse
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 Purity/Purification    Affinity Purification
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 Source    Rabbit
 Immunogen    Recombinant protein of human GLO1
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20C
Avoid freeze/thaw cycles
 Other Notes    Small volumes of anti-GLO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GLO1 antibody

   The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.
 Product Categories/Family for anti-GLO1 antibody    Polyclonal
 Applications Tested/Suitable for anti-GLO1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-GLO1 antibody    WB: 1:500 - 1:2000
IHC/IF: 1:50 - 1:200
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 Western Blot (WB) of anti-GLO1 antibody    Western blot analysis of extracts of various cell lines, using GLO1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-GLO1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GLO1 antibody    Immunohistochemistry of paraffin-embedded mouse kidney using GLO1 antibody at dilution of 1:200 (40x lens).
anti-GLO1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GLO1. It may not necessarily be applicable to this product.
 NCBI GI #    134039205
 NCBI GeneID    2739
 NCBI Accession #    Q04760.4 [Other Products]
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 UniProt Primary Accession #    Q04760 [Other Products]
 UniProt Secondary Accession #    P78375; Q59EL0; Q5TZW3; Q96FC0; Q96J41; B2R6P7; B4DDV0 [Other Products]
 UniProt Related Accession #    Q04760 [Other Products]
 Molecular Weight    Calculated: 19kDa/20kDa
Observed: 21kDa
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 NCBI Official Full Name    Lactoylglutathione lyase
 NCBI Official Synonym Full Names    glyoxalase I
 NCBI Official Symbol    GLO1 [Similar Products]
 NCBI Official Synonym Symbols   
GLYI; GLOD1; HEL-S-74
[Similar Products]
 NCBI Protein Information    lactoylglutathione lyase; glx I; aldoketomutase; methylglyoxalase; ketone-aldehyde mutase; lactoyl glutathione lyase; glyoxalase domain containing 1; epididymis secretory protein Li 74; S-D-lactoylglutathione methylglyoxal lyase
 UniProt Protein Name    Lactoylglutathione lyase
 UniProt Synonym Protein Names   
Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase
 UniProt Gene Name    GLO1 [Similar Products]
 UniProt Synonym Gene Names    Glx I [Similar Products]
 UniProt Entry Name    LGUL_HUMAN
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 NCBI Summary for GLO1    The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GLO1    GLO1: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Belongs to the glyoxalase I family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase

Chromosomal Location of Human Ortholog: 6p21.3-p21.1

Cellular Component: cytoplasm

Molecular Function: zinc ion binding; lactoylglutathione lyase activity

Biological Process: regulation of transcription from RNA polymerase II promoter; glutathione metabolic process; carbohydrate metabolic process; osteoclast differentiation; methylglyoxal metabolic process; negative regulation of apoptosis

Disease: Autism
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 Research Articles on GLO1    1. Overexpression of GLO1 in bone marrow cells is sufficient to overcome the defective neovascularization that is characteristic of diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GLO1 antibodyPathways associated with anti-GLO1 antibody
 Reference Product  PubMed Publications
 PGD antibody  >46 publications with GLO1 and PGD
 SDS antibody  >5 publications with GLO1 and SDS
 HAGH antibody  >3 publications with GLO1 and HAGH
 Products by Pathway  Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
 Methylglyoxal Degradation I Pathway antibodies  Methylglyoxal Degradation I Pathway Diagram
Diseases associated with anti-GLO1 antibodyOrgans/Tissues associated with anti-GLO1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with GLO1 and Inflammation
 Hyperglycemia Antibodies  >11 publications with GLO1 and Hyperglycemia
 Cardiovascular Diseases Antibodies  >11 publications with GLO1 and Cardiovascular Diseases
 Anxiety Disorders Antibodies  >10 publications with GLO1 and Anxiety Disorders
 Brain Diseases Antibodies  >10 publications with GLO1 and Brain Diseases
 Immune System Diseases Antibodies  >10 publications with GLO1 and Immune System Diseases
 Necrosis Antibodies  >7 publications with GLO1 and Necrosis
 Kidney Diseases Antibodies  >6 publications with GLO1 and Kidney Diseases
 Autistic Disorder Antibodies  >6 publications with GLO1 and Autistic Disorder
 Liver Diseases Antibodies  >5 publications with GLO1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >134 publications with GLO1 and Blood
 Brain Antibodies  >24 publications with GLO1 and Brain
 Vascular Antibodies  >17 publications with GLO1 and Vascular
 Kidney Antibodies  >14 publications with GLO1 and Kidney
 Liver Antibodies  >10 publications with GLO1 and Liver
 Heart Antibodies  >9 publications with GLO1 and Heart
 Lung Antibodies  >7 publications with GLO1 and Lung
 Nerve Antibodies  >6 publications with GLO1 and Nerve
 Bone Antibodies  >6 publications with GLO1 and Bone
 Prostate Antibodies  >4 publications with GLO1 and Prostate
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