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anti-GLP1 antibody :: Rabbit GLP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS177908
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GLP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-GLP1 Antibody

 Product Synonym Names    Glucagon; GCG; glicentin-related polypeptide; GLP-1; GLP-1(7-36); GLP-1(7-37); GLP-2; GLP1; GLP1, included; GLP2; GLP2, included; GLUC_HUMAN; Glucagon; Glucagon like peptide 1; glucagon-like peptide 1; Glucagon-like peptide 1, included; Glucagon-like peptide 2; Glucagon-like peptide 2, included; GRPP; OXM; OXY; preproglucagon; glucagon
 Product Gene Name   

anti-GLP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138030
 3D Structure    ModBase 3D Structure for P01275
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    No cross reactivity with other proteins
 Purity/Purification    Immunogen Affinity Purified
 Form/Format    Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human GLP1 (53-81aa HSQGTFTSDYSKYLDSRRAQDFVQWLMNT), identical to the related mouse and rat sequences.
 Reconstitution    0.2ml of distilled water will yield a concentration of 500ug/ml.
 Relevent Detection Systems    Antibody can be supported by MBS176451 in IHC(P).
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 Preparation and Storage    Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GLP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GLP1 antibody

   Description: Rabbit IgG polyclonal antibody for Glucagon(GCG) detection. Tested with IHC-P in Human;Mouse;Rat.

Background: GCG is also known as GLP1, or Glucagon. Glucagon is a 29-amino acid pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. It is mapped to 2q36-2q37. GLP1, also known as 7-37 for the codons of the preproglucagon molecule which encode it, renders pancreatic beta-cells 'glucose-competent' and may be useful in the treatment of noninsulin-dependent diabetes mellitus. Also, GLP1 is a potent insulin secretagogue. It plays a major role in the enteroinsular axis, accounting, for example, for the finding that plasma insulin levels accompanying oral intake of glucose are greater than those observed when glucose is given intravenously.
 Applications Tested/Suitable for anti-GLP1 antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-GLP1 antibody    Immunohistochemistry (IHC) Paraffin:
Concentration: 0.5-1ug/ml
Tested Species: Human, Mouse, Rat
Antigen Retrieval: By Heat

Testes Species: In-house tested species with positive results
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections.

Other applications have not been tested.
ptimal dilutions should be determined by end users.
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 Immunohistochemistry (IHC) of anti-GLP1 antibody    Anti- GLP1 Picoband antibody, IHC(P)
IHC(P): Mouse Pancreas Tissue
anti-GLP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GLP1 antibody    Anti- GLP1 Picoband antibody, IHC(P)
IHC(P): Rat Pancreas Tissue
anti-GLP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GLP1 antibody    Anti- GLP1 Picoband antibody, IHC(P)
IHC(P): Human Pancreatic Cancer Tissue
anti-GLP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GLP1. It may not necessarily be applicable to this product.
 NCBI GI #    4503945
 NCBI GeneID    2641
 NCBI Accession #    NP_002045.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002054.4 [Other Products]
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 UniProt Primary Accession #    P01275 [Other Products]
 UniProt Secondary Accession #    Q53TP6; A6NN65 [Other Products]
 UniProt Related Accession #    P01275 [Other Products]
 Molecular Weight    20,909 Da
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 NCBI Official Full Name    glucagon preproprotein
 NCBI Official Synonym Full Names    glucagon
 NCBI Official Symbol    GCG [Similar Products]
 NCBI Official Synonym Symbols   
GLP1; GLP2; GRPP
[Similar Products]
 NCBI Protein Information    glucagon
 UniProt Protein Name    Glucagon
 UniProt Synonym Protein Names   
GlicentinGlicentin-related polypeptide; GRPP
 Protein Family    Germin-like protein
 UniProt Gene Name    GCG [Similar Products]
 UniProt Synonym Gene Names    GRPP; OXM; OXY; GLP-1; GLP-1(7-37); GLP-1(7-36); GLP-2 [Similar Products]
 UniProt Entry Name    GLUC_HUMAN
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 NCBI Summary for GLP1    The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GLP1    GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family.

Protein type: Secreted, signal peptide; Secreted; Hormone

Chromosomal Location of Human Ortholog: 2q36-q37

Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; plasma membrane

Molecular Function: glucagon receptor binding; hormone activity; identical protein binding; protein binding; receptor binding

Biological Process: cell proliferation; feeding behavior; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of apoptosis; negative regulation of appetite; positive regulation of cAMP biosynthetic process; positive regulation of histone H3-K4 methylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein kinase activity; regulation of insulin secretion; response to starvation; signal transduction
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Product References and Citations for anti-GLP1 antibody

   1. Arora S, Galich P (Mar 2009). "Myth: glucagon is an effective first-line therapy for esophageal foreign body impaction". Cjem 11 (2): 169-71. 2. Holz, G. G., IV, Kuhtreiber, W. M., Habener, J. F. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature 361: 362-365, 1993.  3. Liljenquist JE, Bomboy JD, Lewis SB, Sinclair-Smith BC, Felts PW, Lacy WW, Crofford OB, Liddle GW (Jan 1974). "Effects of glucagon on lipolysis and ketogenesis in normal and diabetic men" (PDF). The Journal of Clinical Investigation 53 (1): 190-7.
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 Research Articles on GLP1    1. Data show that NCI-H716 cells were immunostained for tumor necrosis factor receptor TNFR1, and TNFalpha treatment enhances glucagon-like peptide-1 (GLP-1) secretion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GLP1 antibodyPathways associated with anti-GLP1 antibody
 Reference Product  PubMed Publications
 INS antibody  >19 publications with GLP1 and INS
 GIP antibody  >18 publications with GLP1 and GIP
 GLP1R antibody  >12 publications with GLP1 and GLP1R
 TCF7L2 antibody  >8 publications with GLP1 and TCF7L2
 GCGR antibody  >7 publications with GLP1 and GCGR
 GLP2R antibody  >4 publications with GLP1 and GLP2R
 PAX6 antibody  >4 publications with GLP1 and PAX6
 FOXA2 antibody  >3 publications with GLP1 and FOXA2
 CDX2 antibody  >2 publications with GLP1 and CDX2
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Glucagon Signaling In Metabolic Regulation Pathway antibodies  Glucagon Signaling In Metabolic Regulation Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
Diseases associated with anti-GLP1 antibodyOrgans/Tissues associated with anti-GLP1 antibody
 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >73 publications with GLP1 and Muscular Diseases
 Diabetes Mellitus, Type 2 Antibodies  >28 publications with GLP1 and Diabetes Mellitus, Type 2
 Obesity Antibodies  >22 publications with GLP1 and Obesity
 Vascular Diseases Antibodies  >15 publications with GLP1 and Vascular Diseases
 Hyperglycemia Antibodies  >13 publications with GLP1 and Hyperglycemia
 Insulin Resistance Antibodies  >13 publications with GLP1 and Insulin Resistance
 Kidney Diseases Antibodies  >12 publications with GLP1 and Kidney Diseases
 Liver Diseases Antibodies  >10 publications with GLP1 and Liver Diseases
 Hyperinsulinism Antibodies  >10 publications with GLP1 and Hyperinsulinism
 Pain Antibodies  >9 publications with GLP1 and Pain
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >49 publications with GLP1 and Pancreas
 Liver Antibodies  >23 publications with GLP1 and Liver
 Intestine Antibodies  >21 publications with GLP1 and Intestine
 Connective Tissue Antibodies  >14 publications with GLP1 and Connective Tissue
 Stomach Antibodies  >7 publications with GLP1 and Stomach
 Embryonic Tissue Antibodies  >6 publications with GLP1 and Embryonic Tissue
 Uterus Antibodies  >1 publications with GLP1 and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with GLP1 and Uncharacterized Tissue
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