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anti-GRIA4 antibody :: Rabbit GLUR4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127641
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GLUR4 (GRIA4), Polyclonal Antibody

 Also Known As   

GLUR4 Polyclonal Antibody

 Product Synonym Names    GRIA4 ; GLUR4; GLURD; GluA4; GLUR4C
 Product Gene Name   

anti-GRIA4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (105480800..105852819). Location: 11q22
 OMIM    138246
 3D Structure    ModBase 3D Structure for P48058
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    A synthetic peptide of human GLUR4
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-GRIA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GRIA4 antibody

   AMPA(alphaamino3hydroxy5methyl4isoxazolepropionic acid), kainite, and NMDA(NmethylDaspartate) receptors are the three main families of ionotropic glutamategated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 14), which assemble as homoor heterotetramers to mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization, and plasticity (1). AMPARs that lack GluR 2 are permeable to calcium, in contrast to GluR 2containing AMPARs (2). Posttranscriptional modifications (alternative splicing, nuclear RNA editing) and posttranslational modifications (glycosylation, phosphorylation) result in a very large number of permutations, finetuning the kinetic properties of AMPARs. Research studies have implicated activity changes in AMPARs in a variety of diseases including Alzheimer's, amyotrophic lateral sclerosis (ALS), stroke, and epilepsy (1). GluR 4 containing AMPA receptors are found in synapses and GluR 4 delivery to synapses and cell surface expression is mediated through phosphorylation of Ser842 by PKA or PKC (3).
 Applications Tested/Suitable for anti-GRIA4 antibody   

Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-GRIA4 antibody    Western Blot (WB): 1:500-1:2000
Flow Cytometry (FC/FACS): 1:20-1:100
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 Western Blot (WB) of anti-GRIA4 antibody    Western blot analysis of extracts of various cell lines, using GRIA4 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5s.
anti-GRIA4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GRIA4. It may not necessarily be applicable to this product.
 NCBI GI #    164419734
 NCBI GeneID    2893
 NCBI Accession #    NP_000820.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000829.3 [Other Products]
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 UniProt Primary Accession #    P48058 [Other Products]
 UniProt Secondary Accession #    Q86XE8 [Other Products]
 UniProt Related Accession #    P48058 [Other Products]
 Molecular Weight    101kDa [Similar Products]
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 NCBI Official Full Name    glutamate receptor 4 isoform 1
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, AMPA 4
 NCBI Official Symbol    GRIA4 [Similar Products]
 NCBI Official Synonym Symbols   
GLUR4; GLURD; GluA4; GLUR4C
[Similar Products]
 NCBI Protein Information    glutamate receptor 4; gluR-4; gluR-D; AMPA-selective glutamate receptor 4; glutamate receptor, ionotrophic, AMPA 4
 UniProt Protein Name    Glutamate receptor 4
 UniProt Synonym Protein Names   
AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic, AMPA 4
 Protein Family    Glutamate receptor
 UniProt Gene Name    GRIA4 [Similar Products]
 UniProt Synonym Gene Names    GLUR4; GluR-4; GluR4; GluA4 [Similar Products]
 UniProt Entry Name    GRIA4_HUMAN
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Product References and Citations for anti-GRIA4 antibody

   1. Palmer, C.L. et al. (2005) Pharmacol Rev 57, 25377. 2. CullCandy, S. et al. (2006) Curr Opin Neurobiol 16, 28897. 3. Gomes, A.R. et al. (2007) Traffic 8, 259269.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GRIA4 antibodyPathways associated with anti-GRIA4 antibody
 Reference Product  PubMed Publications
 GRIA1 antibody  >8 publications with GRIA4 and GRIA1
 GRIN2B antibody  >1 publications with GRIA4 and GRIN2B
 GRIN2A antibody  >1 publications with GRIA4 and GRIN2A
 CACNG2 antibody  >1 publications with GRIA4 and CACNG2
 Products by Pathway  Pathway Diagram
 Activation Of AMPA Receptors Pathway antibodies  Activation Of AMPA Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
Diseases associated with anti-GRIA4 antibodyOrgans/Tissues associated with anti-GRIA4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >14 publications with GRIA4 and Nervous System Diseases
 Brain Diseases Antibodies  >11 publications with GRIA4 and Brain Diseases
 Seizures Antibodies  >4 publications with GRIA4 and Seizures
 Disease Models, Animal Antibodies  >3 publications with GRIA4 and Disease Models, Animal
 Neoplasms Antibodies  >2 publications with GRIA4 and Neoplasms
 Catalepsy Antibodies  >1 publications with GRIA4 and Catalepsy
 Pain Antibodies  >1 publications with GRIA4 and Pain
 Hyperplasia Antibodies  >1 publications with GRIA4 and Hyperplasia
 Inflammation Antibodies  >1 publications with GRIA4 and Inflammation
 Myopia Antibodies  >1 publications with GRIA4 and Myopia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with GRIA4 and Brain
 Nerve Antibodies  >1 publications with GRIA4 and Nerve
 Lymph Antibodies  >1 publications with GRIA4 and Lymph
 Eye Antibodies  >1 publications with GRIA4 and Eye
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