Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow Gad2 rightarrow Polyclonal Gad2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Epidermal Growth Factor (EGF) ELISA Kit
 • DECR1 Blocking Peptide
 • Centrin-2 (CETN2) ELISA Kit
 • Z-DNA binding protein 1 (ZBP1) Antibody
 • ALPHA 2 MACROGLOBULIN (A2M) Purified Protein
 • Coagulation Factor VIII (F8) ELISA Kit
 • Agouti Related Protein (AGRP) ELISA Kit
 • IGFBP3 Antibody
 • Placental Alkaline Phosphatase (PLAP) ELISA Kit
 • IL-23 (IL23A) Antibody
 • IFNL4 siRNA
 • Interferon Gamma (IFN-gamma) ELISA Kit
 • Complement Component 3 (C3) Protein
 • indoleamine 2, 3-dioxygenase 1 (IDO1) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-Gad2 antibody :: Rabbit GLUTAMATE DECARBOXYLASE 1/2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221561 anti-Gad2 antibody
Unit / Price
0.1 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GLUTAMATE DECARBOXYLASE 1/2 (Gad2), Polyclonal Antibody

 Also Known As   

RABBIT ANTI GLUTAMATE DECARBOXYLASE 1/2

 Product Gene Name   

anti-Gad2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for Q05683
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Cat, Human, Mouse
Section Bar
 Specificity    This product recognises both molecular forms of glutamate decarboxylase, GAD1 (GAD67) and GAD2 (GAD65), the enzyme which converts glutamic acid to gamma -aminobutyric acid (GABA), the major inhibitory transmitter in the higher brain region.
 Form/Format    Purified
Purified IgG - liquid
Section Bar
 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
 Immunogen    Synthetic peptide sequence D-F-L-I-E-E-I-E-R-L-G-Q-D-L from the C terminus of rat GAD2
Histology Positive Control Tissue
 Antiserum Preparation    Antiserum to glutamic acid decarboxylase was raised by repeated immunisation of with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on protein A.
 Target Species    Rat
Section Bar
 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-Gad2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-Gad2 antibody

   This product recognises both molecular forms of glutamate decarboxylase, GAD1 (GAD67) and GAD2 (GAD65), the enzyme which converts glutamic acid to gamma -aminobutyric acid (GABA), the major inhibitory transmitter in the higher brain region.
 Applications Tested/Suitable for anti-Gad2 antibody   

Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin, Western Blot (WB)

 Application Notes for anti-Gad2 antibody    Western Blot: A doublet at approximately 65/67 kDa can be expected
Immunohistology - Frozen: Minimum Dilution: 1/200; Maximum Dilution: 1/5000
Western Blotting: Minimum Dilution: 1/1000; Maximum Dilution: 1/10000
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for Gad2. It may not necessarily be applicable to this product.
 NCBI GI #    6978871
 NCBI GeneID    24380
 NCBI Accession #    NP_036695.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012563.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q05683 [Other Products]
 UniProt Related Accession #    Q05683 [Other Products]
 Molecular Weight    65,402 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    glutamate decarboxylase 2
 NCBI Official Synonym Full Names    glutamate decarboxylase 2
 NCBI Official Symbol    Gad2 [Similar Products]
 NCBI Official Synonym Symbols   
gad65
[Similar Products]
 NCBI Protein Information    glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; glutamic acid decarboxylase 65
 UniProt Protein Name    Glutamate decarboxylase 2
 UniProt Synonym Protein Names   
65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform
 Protein Family    Glutamate decarboxylase
 UniProt Gene Name    Gad2 [Similar Products]
 UniProt Synonym Gene Names    Gad65; GAD-65 [Similar Products]
 UniProt Entry Name    DCE2_RAT
Section Bar
 NCBI Summary for Gad2    catalyzes synthesis of gamma-Aminobutyric acid (GABA), the most widely distributed inhibitory neurotransmitter [RGD, Feb 2006]
Section Bar
 UniProt Comments for Gad2    GAD2: Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family.

Protein type: Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - alanine, aspartate and glutamate; Lyase; EC 4.1.1.15; Other Amino Acids Metabolism - taurine and hypotaurine

Cellular Component: Golgi membrane; presynaptic membrane; synaptic vesicle membrane; perinuclear region of cytoplasm; axon; cytoplasm; synapse; cytoplasmic vesicle; cell junction; cytosol

Molecular Function: glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; pyridoxal phosphate binding

Biological Process: response to drug; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter biosynthetic process
Table BarTOPTable Bar
 Research Articles on Gad2    1. experimental reduction of GAD65/67 expression bilaterally in the NAcbC is sufficient to increase impulsivity in LI rats.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-Gad2 antibodyPathways associated with anti-Gad2 antibody
 Reference Product  PubMed Publications
 Abat antibody  >1 publications with Gad2 and Abat
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA Synthesis Pathway antibodies  GABA Synthesis Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Diseases associated with anti-Gad2 antibodyOrgans/Tissues associated with anti-Gad2 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >20 publications with Gad2 and Mental Disorders
 Nervous System Diseases Antibodies  >13 publications with Gad2 and Nervous System Diseases
 Brain Diseases Antibodies  >11 publications with Gad2 and Brain Diseases
 Schizophrenia Antibodies  >10 publications with Gad2 and Schizophrenia
 Epilepsy Antibodies  >6 publications with Gad2 and Epilepsy
 Seizures Antibodies  >6 publications with Gad2 and Seizures
 Depressive Disorder Antibodies  >4 publications with Gad2 and Depressive Disorder
 Inflammation Antibodies  >4 publications with Gad2 and Inflammation
 Movement Disorders Antibodies  >2 publications with Gad2 and Movement Disorders
 Substance Withdrawal Syndrome Antibodies  >2 publications with Gad2 and Substance Withdrawal Syndrome
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >37 publications with Gad2 and Brain
 Mixed Antibodies  >2 publications with Gad2 and Mixed
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions