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anti-GM-CSF antibody :: Rabbit anti-Mouse, Rat GM-CSF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS551019 anti-GM-CSF antibody
Unit / Price
0.1 mg  /  $280 +1 FREE 8GB USB
0.2 mg  /  $385 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GM-CSF, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti GM-CSF Polyclonal

 Product Synonym Names    Rabbit anti GM-CSF Polyclonal purified; GM-CSF; gmcsf; csf2; Granulocyte Macrophage-Colony Stimulating Factor; polyclonal; pab
 Product Gene Name   

anti-GM-CSF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138960
 3D Structure    ModBase 3D Structure for P04141
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse, Rat
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 Purity/Purification    Purification: IgG fraction was purified by Protein G affinity chromatography.
Purity: >95%
 Form/Format    Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.
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 Source Note    Polyclonal GM-CSF antibody was produced from sera of rabbits immunized with synthetic protein containing GM-CSF antigenic determinants.
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers
 Presentation    Lyophilized from 0.2 um filtered solution in PBS pH 7.4.
 Reconsitution    Add 100ul of distilled H20 for a concentration of 1mg/ml.
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 Preparation and Storage    The lyophilized antibody is stable for at least 1 year from date of receipt at -20degree C. Upon reconstitution, this antibody can be stored in working aliquots at 20 - 80 degree C for one month, or at -20 degree C for six months without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-GM-CSF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GM-CSF antibody

   GM-CSF is a monomeric protein of 127 amino acids with two glycosylation sites. The protein is synthesized as a precursor of 144 amino acids, which included a hydrophobic secretory signal sequence at the aminoterminal end. The sugar moiety is not required for the full spectrum of biological activities. Non- glycosylated and glycosylated GM-CSF show the same activities in vitro. Fully glycosylated GM-CSF is biologically more active in vivo than the non- glycosylated protein. This protein is secreted together with other factors by T- cells and macrophages following cell activation by antigens or mitogens. Approximately 90% of the secreted colony stimulating activities are due to GM- CSF.
 Product Categories/Family for anti-GM-CSF antibody    Polyclonal
 Applications Tested/Suitable for anti-GM-CSF antibody   

Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)

 Application Notes for anti-GM-CSF antibody    ELISA: Use at a concentration range of 1-2ug/ml.
Western blot: A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml.
IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
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NCBI/Uniprot data below describe general gene information for GM-CSF. It may not necessarily be applicable to this product.
 NCBI GI #    27437030
 NCBI GeneID    1437
 NCBI Accession #    NP_000749.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000758.3 [Other Products]
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 UniProt Primary Accession #    P04141 [Other Products]
 UniProt Secondary Accession #    Q14CE8; Q2VPI8; Q8NFI6 [Other Products]
 UniProt Related Accession #    P04141; Q647J8 [Other Products]
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 NCBI Official Full Name    granulocyte-macrophage colony-stimulating factor
 UniProt Protein Name    Granulocyte-macrophage colony-stimulating factor
 UniProt Synonym Protein Names   
Colony-stimulating factor; CSF; Molgramostin; Sargramostim
 UniProt Gene Name    CSF2 [Similar Products]
 UniProt Synonym Gene Names    GMCSF; GM-CSF; CSF [Similar Products]
 UniProt Entry Name    CSF2_HUMAN
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 NCBI Summary for GM-CSF    The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GM-CSF    GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; epithelial fluid transport; macrophage activation; embryonic placenta development; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; myeloid dendritic cell differentiation; immune response; positive regulation of DNA replication
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Product References and Citations for anti-GM-CSF antibody

   GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions .J. Exp. Med., Sep 2009; 206: 2141 - 2149.
the transcription factors stat5a/b regulate GM-CSF-mediated granulopoiesis .Blood, Sep 2009; 10.1182/blood-2009-04-216390.
GM-CSF and il-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through m-csf receptor shedding by up-regulation of tnf- converting enzyme (tace) .Blood, Sep 2009; 10.1182/blood-2009-04-215020.
biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation .PNAS, Sep 2009; 106: 15825 - 15830.
stress response genes are suppressed in mouse preimplantation embryos by granulocyte-macrophage colony-stimulating factor (GM-CSF) .Hum. Reprod., Sep 2009; 10.1093/humrep/dep307.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GM-CSF antibodyPathways associated with anti-GM-CSF antibody
 Reference Product  PubMed Publications
 CSF2RB antibody  >6 publications with GM-CSF and CSF2RB
 CSF2RA antibody  >4 publications with GM-CSF and CSF2RA
 KITLG antibody  >2 publications with GM-CSF and KITLG
 IL3RA antibody  >2 publications with GM-CSF and IL3RA
 SDC2 antibody  >1 publications with GM-CSF and SDC2
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
Diseases associated with anti-GM-CSF antibodyOrgans/Tissues associated with anti-GM-CSF antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >17 publications with GM-CSF and Necrosis
 Inflammation Antibodies  >14 publications with GM-CSF and Inflammation
 Neoplasms Antibodies  >10 publications with GM-CSF and Neoplasms
 Immune System Diseases Antibodies  >9 publications with GM-CSF and Immune System Diseases
 Respiratory Tract Diseases Antibodies  >6 publications with GM-CSF and Respiratory Tract Diseases
 Bacterial Infections Antibodies  >6 publications with GM-CSF and Bacterial Infections
 Leukemia Antibodies  >6 publications with GM-CSF and Leukemia
 Hematologic Diseases Antibodies  >6 publications with GM-CSF and Hematologic Diseases
 Lung Diseases Antibodies  >5 publications with GM-CSF and Lung Diseases
 Bone Marrow Diseases Antibodies  >5 publications with GM-CSF and Bone Marrow Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with GM-CSF and Blood
 Bone Antibodies  >6 publications with GM-CSF and Bone
 Lung Antibodies  >3 publications with GM-CSF and Lung
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