NP_006487.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated: 40kDa Observed: 45kDa
NCBI Official Full Name
guanine nucleotide-binding protein G(k) subunit alpha
NCBI Official Synonym Full Names
G protein subunit alpha i3
NCBI Official Synonym Symbols
NCBI Protein Information
guanine nucleotide-binding protein G(k) subunit alpha
UniProt Protein Name
Guanine nucleotide-binding protein G(k) subunit alpha
UniProt Synonym Protein Names
G(i) alpha-3
NCBI Summary for GNAI3
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]
UniProt Comments for GNAI3
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K+ channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).
Research Articles on GNAI3
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Products associated with anti-GNAI3 antibody
Pathways associated with anti-GNAI3 antibody
Diseases associated with anti-GNAI3 antibody
Organs/Tissues associated with anti-GNAI3 antibody
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