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anti-GNAS antibody :: Rabbit GNAS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9126568
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GNAS, Polyclonal Antibody

 Also Known As   

GNAS Polyclonal Antibody

 Product Synonym Names    AHO; GSA; GSP; POH; GPSA; NESP; GNAS1; PHP1A; PHP1B; PHP1C; C20orf45
 Product Gene Name   

anti-GNAS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 612462
 3D Structure    ModBase 3D Structure for P63092
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human GNAS
 Calculated Molecular Weight    67kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-GNAS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GNAS antibody

   This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
 Product Categories/Family for anti-GNAS antibody    Polyclonal
 Applications Tested/Suitable for anti-GNAS antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-GNAS antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-GNAS antibody    Western blot analysis of extracts of various cell lines, using GNAS antibody.
anti-GNAS antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GNAS. It may not necessarily be applicable to this product.
 NCBI GI #    52000961
 NCBI GeneID    2778
 NCBI Accession #    P63092.1 [Other Products]
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 UniProt Primary Accession #    P63092 [Other Products]
 UniProt Secondary Accession #    P04895; Q12927; Q14433; Q32P26; Q5JWD2; Q5JWD4; Q5JWD5; Q6NR75; Q6NXS0; A6NI00; E1P5G5 [Other Products]
 UniProt Related Accession #    O95467; P63092; P84996; Q5JWF2 [Other Products]
 Molecular Weight    626
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 NCBI Official Full Name    Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
 NCBI Official Synonym Full Names    GNAS complex locus
 NCBI Official Symbol    GNAS [Similar Products]
 NCBI Official Synonym Symbols   
AHO; GSA; GSP; POH; GPSA; NESP; GNAS1; PHP1A; PHP1B; PHP1C; C20orf45
[Similar Products]
 NCBI Protein Information    protein ALEX; protein GNAS; protein NESP55; secretogranin VI; extra large alphas protein; neuroendocrine secretory protein; guanine nucleotide regulatory protein; alternative gene product encoded by XL-exon; adenylate cyclase-stimulating G alpha protein; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
 UniProt Protein Name    Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
 UniProt Synonym Protein Names   
Adenylate cyclase-stimulating G alpha protein
 Protein Family    Protein
 UniProt Gene Name    GNAS [Similar Products]
 UniProt Synonym Gene Names    GNAS1; GSP [Similar Products]
 UniProt Entry Name    GNAS2_HUMAN
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 NCBI Summary for GNAS    This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
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 UniProt Comments for GNAS    G-alpha(s): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein type: Vesicle; Membrane protein, peripheral; G protein; G protein, heterotrimeric; Oncoprotein; G protein, heterotrimeric alpha G(s)

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: dendrite; extracellular region; cytosol; ruffle; transport vesicle; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; heterotrimeric G-protein complex; intrinsic to membrane; trans-Golgi network membrane; nucleus

Molecular Function: corticotropin-releasing hormone receptor 1 binding; GTPase activity; ionotropic glutamate receptor binding; insulin-like growth factor receptor binding; signal transducer activity; protein binding; GTP binding; mu-type opioid receptor binding; metal ion binding; beta-2 adrenergic receptor binding; G-protein beta/gamma-subunit binding; D1 dopamine receptor binding; adenylate cyclase activity

Biological Process: developmental growth; positive regulation of osteoclast differentiation; water transport; protein secretion; female pregnancy; G-protein signaling, adenylate cyclase activating pathway; embryonic hindlimb morphogenesis; intracellular transport; positive regulation of cAMP biosynthetic process; DNA methylation; tissue homeostasis; transmembrane transport; post-embryonic body morphogenesis; dopamine receptor, adenylate cyclase activating pathway; endochondral ossification; response to drug; sensory perception of chemical stimulus; negative regulation of multicellular organism growth; multicellular organism growth; sensory perception of smell; adenylate cyclase activation; embryonic cranial skeleton morphogenesis; positive regulation of osteoblast differentiation; cartilage development; energy reserve metabolic process; renal water homeostasis; cAMP biosynthetic process; cognition; blood coagulation; regulation of insulin secretion

Disease: Osseous Heteroplasia, Progressive; Pseudohypoparathyroidism, Type Ic; Pseudopseudohypoparathyroidism; Acth-independent Macronodular Adrenal Hyperplasia; Mccune-albright Syndrome; Pseudohypoparathyroidism, Type Ia; Pseudohypoparathyroidism, Type Ib; Pituitary Adenoma, Growth Hormone-secreting
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 Research Articles on GNAS    1. Galphas down-expression is associated with adverse pathologic features and clinical PSA biochemical recurrence of prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GNAS antibodyDiseases associated with anti-GNAS antibody
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Disease Name  Pubmed Publications
 Pseudopseudohypoparathyroidism Antibodies  >171 publications with GNAS and Pseudopseudohypoparathyroidism
 PSEUDOHYPOPARATHYROIDISM, TYPE IA Antibodies  >171 publications with GNAS and PSEUDOHYPOPARATHYROIDISM, TYPE IA
 Pseudohypoparathyroidism Antibodies  >171 publications with GNAS and Pseudohypoparathyroidism
 Endocrine System Diseases Antibodies  >146 publications with GNAS and Endocrine System Diseases
 Fibrous Dysplasia, Polyostotic Antibodies  >104 publications with GNAS and Fibrous Dysplasia, Polyostotic
 Obesity Antibodies  >59 publications with GNAS and Obesity
 Albright's hereditary osteodystrophy Antibodies  >55 publications with GNAS and Albright's hereditary osteodystrophy
 Kidney Diseases Antibodies  >32 publications with GNAS and Kidney Diseases
 Ossification, Heterotopic Antibodies  >29 publications with GNAS and Ossification, Heterotopic
 Brachydactyly Antibodies  >24 publications with GNAS and Brachydactyly
Organs/Tissues associated with anti-GNAS antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >132 publications with GNAS and Bone
 Blood Antibodies  >125 publications with GNAS and Blood
 Parathyroid Antibodies  >87 publications with GNAS and Parathyroid
 Skin Antibodies  >55 publications with GNAS and Skin
 Nerve Antibodies  >54 publications with GNAS and Nerve
 Thyroid Antibodies  >54 publications with GNAS and Thyroid
 Kidney Antibodies  >49 publications with GNAS and Kidney
 Brain Antibodies  >45 publications with GNAS and Brain
 Pancreas Antibodies  >39 publications with GNAS and Pancreas
 Muscle Antibodies  >33 publications with GNAS and Muscle
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