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anti-GNPAT antibody :: Rabbit GNPAT Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS129275
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GNPAT, Polyclonal Antibody

★Popular Item★
 Also Known As   

GNPAT Polyclonal Antibody

 Product Synonym Names    DAPAT; DAP-AT; DHAPAT
 Product Gene Name   

anti-GNPAT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 602744
 3D Structure    ModBase 3D Structure for O15228
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human GNPAT
 Calculated Molecular Weight    77kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-GNPAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GNPAT antibody

   This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata.
 Product Categories/Family for anti-GNPAT antibody    Polyclonal
 Applications Tested/Suitable for anti-GNPAT antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-GNPAT antibody    WB: 1:500 - 1:2000
IF: 1:50 - 1:200
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 Western Blot (WB) of anti-GNPAT antibody    Western blot analysis of extracts of various cell lines, using GNPAT antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5s.
anti-GNPAT antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GNPAT. It may not necessarily be applicable to this product.
 NCBI GI #    3913409
 NCBI GeneID    8443
 NCBI Accession #    O15228.1 [Other Products]
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 UniProt Primary Accession #    O15228 [Other Products]
 UniProt Secondary Accession #    Q5TBH7; Q9BWC2; B4DNM9 [Other Products]
 UniProt Related Accession #    O15228 [Other Products]
 Molecular Weight    680
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 NCBI Official Full Name    Dihydroxyacetone phosphate acyltransferase
 NCBI Official Synonym Full Names    glyceronephosphate O-acyltransferase
 NCBI Official Symbol    GNPAT [Similar Products]
 NCBI Official Synonym Symbols   
DAPAT; DAP-AT; DHAPAT
[Similar Products]
 NCBI Protein Information    dihydroxyacetone phosphate acyltransferase; DHAP-AT; glycerone-phosphate O-acyltransferase; acyl-CoA:dihydroxyacetonephosphateacyltransferase
 UniProt Protein Name    Dihydroxyacetone phosphate acyltransferase
 UniProt Synonym Protein Names   
Acyl-CoA:dihydroxyacetonephosphateacyltransferase; Glycerone-phosphate O-acyltransferase
 Protein Family    Dihydroxyacetone phosphate acyltransferase
 UniProt Gene Name    GNPAT [Similar Products]
 UniProt Synonym Gene Names    DAPAT; DHAPAT; DAP-AT; DHAP-AT [Similar Products]
 UniProt Entry Name    GNPAT_HUMAN
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 NCBI Summary for GNPAT    This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GNPAT    GNPAT: Defects in GNPAT are the cause of rhizomelic chondrodysplasia punctata type 2 (RCDP2). RDCP2 is characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation. Belongs to the GPAT/DAPAT family.

Protein type: EC 2.3.1.42; Lipid Metabolism - glycerophospholipid; Transferase

Chromosomal Location of Human Ortholog: 1q42

Cellular Component: peroxisomal membrane; peroxisomal matrix; mitochondrion; membrane; peroxisome

Molecular Function: glycerone-phosphate O-acyltransferase activity; palmitoyl-CoA hydrolase activity; receptor binding

Biological Process: response to drug; response to starvation; synaptogenesis; phospholipid metabolic process; glycerophospholipid biosynthetic process; cerebellum morphogenesis; phosphatidic acid biosynthetic process; cellular lipid metabolic process; response to nutrient; ether lipid biosynthetic process; paranodal junction assembly

Disease: Rhizomelic Chondrodysplasia Punctata, Type 2
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 Research Articles on GNPAT    1. ACOX1 and GNPAT silencing up-regulated ceramide galactosyltransferase (UGT8) mRNA expression, and down-regulated UDP-glucoseceramide glucosyltransferase (UGCG).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GNPAT antibodyPathways associated with anti-GNPAT antibody
 Reference Product  PubMed Publications
 AGPS antibody  >4 publications with GNPAT and AGPS
 PEX7 antibody  >3 publications with GNPAT and PEX7
 FAR1 antibody  >1 publications with GNPAT and FAR1
 Products by Pathway  Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Peroxisomal Lipid Metabolism Pathway antibodies  Peroxisomal Lipid Metabolism Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Phospholipid Metabolism Pathway antibodies  Phospholipid Metabolism Pathway Diagram
 Plasmalogen Biosynthesis Pathway antibodies  Plasmalogen Biosynthesis Pathway Diagram
Diseases associated with anti-GNPAT antibodyOrgans/Tissues associated with anti-GNPAT antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with GNPAT and Nervous System Diseases
 Limb Deformities, Congenital Antibodies  >1 publications with GNPAT and Limb Deformities, Congenital
 Liver Diseases Antibodies  >1 publications with GNPAT and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with GNPAT and Kidney Diseases
 Abnormalities, Multiple Antibodies  >1 publications with GNPAT and Abnormalities, Multiple
 Seizures Antibodies  >1 publications with GNPAT and Seizures
 Fatty Liver Antibodies  >1 publications with GNPAT and Fatty Liver
 Rhizomelic chondrodysplasia punctata, type 2 Antibodies  >1 publications with GNPAT and Rhizomelic chondrodysplasia punctata, type 2
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with GNPAT and Blood
 Kidney Antibodies  >2 publications with GNPAT and Kidney
 Brain Antibodies  >2 publications with GNPAT and Brain
 Liver Antibodies  >1 publications with GNPAT and Liver
 Thymus Antibodies  >1 publications with GNPAT and Thymus
 Skin Antibodies  >1 publications with GNPAT and Skin
 Testis Antibodies  >1 publications with GNPAT and Testis
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