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anti-GPAM antibody :: Rabbit GPAT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150163
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GPAT1 (GPAM), Polyclonal Antibody

 Also Known As   

GPAT1 Antibody

 Product Synonym Names    GPAT1; GPAT; GPAT1; KIAA1560; Glycerol-3-phosphate acyltransferase 1; mitochondrial; GPAT-1; glycerol-3-phosphate acyltransferase, mitochondrial
 Product Gene Name   

anti-GPAM antibody

[Similar Products]
 Antibody/Peptide Pairs    GPAT1 peptide (MBS152752) is used for blocking the activity of GPAT1 antibody (MBS150163)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602395
 3D Structure    ModBase 3D Structure for Q9HCL2
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    GPAT1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    GPAT1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human GPAT1.
 Buffer    GPAT1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    GPAT1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-GPAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GPAM antibody

   GPAT1 Antibody: Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
 Applications Tested/Suitable for anti-GPAM antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-GPAM antibody    GPAT1 antibody can be used for detection of GPAT1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-GPAM antibody    Western blot analysis of GPAT1 in rat brain tissue lysate with GPAT1 antibody at (A) 1 and (B) 2 μg/mL.
anti-GPAM antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GPAM antibody    Immunohistochemistry of GPAT1 in rat brain with GPAT1 antibody at 2.5 μg/mL.
anti-GPAM antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GPAM. It may not necessarily be applicable to this product.
 NCBI GI #    190358539
 NCBI GeneID    57678
 NCBI Accession #    NP_065969 [Other Products]
 NCBI GenBank Nucleotide #    NM_020918.5 [Other Products]
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 UniProt Primary Accession #    Q9HCL2 [Other Products]
 UniProt Secondary Accession #    Q5VW51; Q86TA3 [Other Products]
 UniProt Related Accession #    Q9HCL2 [Other Products]
 Molecular Weight    93,795 Da
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 NCBI Official Full Name    glycerol-3-phosphate acyltransferase 1, mitochondrial
 NCBI Official Synonym Full Names    glycerol-3-phosphate acyltransferase, mitochondrial
 NCBI Official Symbol    GPAM [Similar Products]
 NCBI Official Synonym Symbols   
GPAT; GPAT1
[Similar Products]
 NCBI Protein Information    glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT-1; glycerol 3-phosphate acyltransferase, mitochondrial
 UniProt Protein Name    Glycerol-3-phosphate acyltransferase 1, mitochondrial
 UniProt Gene Name    GPAM [Similar Products]
 UniProt Synonym Gene Names    GPAT1; KIAA1560; GPAT-1 [Similar Products]
 UniProt Entry Name    GPAT1_HUMAN
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 NCBI Summary for GPAM    This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for GPAM    GPAM: glycerol-3-phosphate acyltransferase is an integral multi-pass enzyme of the mitochondrial outer membrane. It performs the first step in de novo phospholipid biosynthesis. Member of the phospholipid and glycerol acyltransferase family

Protein type: Lipid Metabolism - glycerolipid; Mitochondrial; Lipid Metabolism - glycerophospholipid; Membrane protein, multi-pass; Transferase; Membrane protein, integral; EC 2.3.1.15

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: mitochondrial outer membrane; mitochondrial inner membrane; integral to membrane; plasma membrane

Molecular Function: glycerol-3-phosphate O-acyltransferase activity

Biological Process: regulation of cytokine secretion; acyl-CoA metabolic process; glycerophospholipid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; positive regulation of multicellular organism growth; fatty acid metabolic process; positive regulation of activated T cell proliferation; fatty acid homeostasis; phospholipid metabolic process; response to glucose stimulus; phosphatidic acid biosynthetic process; CDP-diacylglycerol biosynthetic process; defense response to virus; phospholipid homeostasis
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 Research Articles on GPAM    1. two transcriptional initiation sites and two promoters (promoter I and II) required for expression of the human GPAT1 (hGPAT1) gene were identified.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GPAM antibodyPathways associated with anti-GPAM antibody
 Reference Product  PubMed Publications
 AGPAT3 antibody  >2 publications with GPAM and AGPAT3
 GPD1 antibody  >1 publications with GPAM and GPD1
 AGPAT4 antibody  >1 publications with GPAM and AGPAT4
 AGPAT6 antibody  >1 publications with GPAM and AGPAT6
 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 CDP-diacylglycerol Biosynthesis Pathway antibodies  CDP-diacylglycerol Biosynthesis Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with anti-GPAM antibodyOrgans/Tissues associated with anti-GPAM antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >9 publications with GPAM and Fatty Liver
 Inflammation Antibodies  >8 publications with GPAM and Inflammation
 Liver Diseases Antibodies  >5 publications with GPAM and Liver Diseases
 Dyslipidemias Antibodies  >3 publications with GPAM and Dyslipidemias
 Insulin Resistance Antibodies  >3 publications with GPAM and Insulin Resistance
 Cardiovascular Diseases Antibodies  >2 publications with GPAM and Cardiovascular Diseases
 Atherosclerosis Antibodies  >2 publications with GPAM and Atherosclerosis
 Hypertriglyceridemia Antibodies  >2 publications with GPAM and Hypertriglyceridemia
 Hyperlipidemias Antibodies  >2 publications with GPAM and Hyperlipidemias
 Kidney Diseases Antibodies  >1 publications with GPAM and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >18 publications with GPAM and Liver
 Blood Antibodies  >15 publications with GPAM and Blood
 Adipose Tissue Antibodies  >12 publications with GPAM and Adipose Tissue
 Lung Antibodies  >6 publications with GPAM and Lung
 Muscle Antibodies  >4 publications with GPAM and Muscle
 Mammary Gland Antibodies  >4 publications with GPAM and Mammary Gland
 Heart Antibodies  >2 publications with GPAM and Heart
 Thyroid Antibodies  >2 publications with GPAM and Thyroid
 Placenta Antibodies  >1 publications with GPAM and Placenta
 Embryonic Tissue Antibodies  >1 publications with GPAM and Embryonic Tissue
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