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anti-GPBAR1 antibody :: Rabbit GPBAR1 / TGR5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS244856
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GPBAR1 / TGR5, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human GPBAR1 / TGR5

 Product Synonym Names    Anti-GPBAR1 / TGR5 Antibody (C-Terminus) IHC-plus; GPBAR1; BG37; GPR131; HGPCR19; M-BAR; GPCR19; TGR5; GPCR TGR5; HBG37; Membrane bile acid receptor; Human GPBAR1; TGR5
 Product Gene Name   

anti-GPBAR1 antibody

[Similar Products]
 Product Synonym Gene Name    TGR5 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610147
 3D Structure    ModBase 3D Structure for Q8TDU6
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gorilla, Human
Predicted Reactivity: Gibbon, Monkey (at least 90% immunogen sequence identity)
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 Specificity    Human TGR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 16 amino acid peptide from C-terminus of human TGR5. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Marmoset (94%).
 Immunogen Type    Synthetic peptide
 Immunogen    GPBAR1 / TGR5 antibody was raised against synthetic 16 amino acid peptide from C-terminus of human TGR5. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Marmoset (94%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-GPBAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GPBAR1 antibody

   BG37/TGR5 is the first Bile Acid GPCR to be identified.
 Product Categories/Family for anti-GPBAR1 antibody    Family: GPCR
Subfamily: Bile Acids
 Applications Tested/Suitable for anti-GPBAR1 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-GPBAR1 antibody    IHC-P (11 - 27 ug/ml)
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 Immunohistochemistry (IHC) of anti-GPBAR1 antibody    Anti-GPBAR1 / TGR5 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPBAR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPBAR1 antibody    Anti-TGR5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPBAR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPBAR1 antibody    Anti-GPBAR1 / TGR5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPBAR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPBAR1 antibody    Anti-GPBAR1 / TGR5 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPBAR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPBAR1 antibody    Anti-GPBAR1 / TGR5 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPBAR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GPBAR1. It may not necessarily be applicable to this product.
 NCBI GI #    24850109
 NCBI GeneID    151306
 NCBI Accession #    NP_733800.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_170699.2 [Other Products]
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 UniProt Primary Accession #    Q8TDU6 [Other Products]
 UniProt Secondary Accession #    B3KV35 [Other Products]
 UniProt Related Accession #    Q8TDU6 [Other Products]
 Molecular Weight    35,248 Da
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 NCBI Official Full Name    G-protein coupled bile acid receptor 1
 NCBI Official Synonym Full Names    G protein-coupled bile acid receptor 1
 NCBI Official Symbol    GPBAR1 [Similar Products]
 NCBI Official Synonym Symbols   
BG37; TGR5; M-BAR; GPCR19; GPR131
[Similar Products]
 NCBI Protein Information    G-protein coupled bile acid receptor 1; hBG37; hGPCR19; membrane bile acid receptor; G-protein coupled receptor GPCR19; membrane-type receptor for bile acids; G-protein coupled bile acid receptor BG37
 UniProt Protein Name    G-protein coupled bile acid receptor 1
 UniProt Synonym Protein Names   
G-protein coupled receptor GPCR19; hGPCR19; Membrane-type receptor for bile acids; M-BAR; hBG37; BG37
 Protein Family    G-protein coupled bile acid receptor
 UniProt Gene Name    GPBAR1 [Similar Products]
 UniProt Synonym Gene Names    TGR5; hGPCR19; M-BAR; BG37 [Similar Products]
 UniProt Entry Name    GPBAR_HUMAN
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 NCBI Summary for GPBAR1    This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GPBAR1    GPBAR1: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Biological Process: G-protein coupled receptor protein signaling pathway
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 Research Articles on GPBAR1    1. GPBAR1 SNP is associated with symptoms and pathobiology in IBS-D and IBS-C.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GPBAR1 antibodyPathways associated with anti-GPBAR1 antibody
 Reference Product  PubMed Publications
 GCG antibody  >2 publications with GPBAR1 and GCG
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-GPBAR1 antibodyOrgans/Tissues associated with anti-GPBAR1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >32 publications with GPBAR1 and Liver Diseases
 Inflammation Antibodies  >22 publications with GPBAR1 and Inflammation
 Cholestasis Antibodies  >12 publications with GPBAR1 and Cholestasis
 Fatty Liver Antibodies  >10 publications with GPBAR1 and Fatty Liver
 Necrosis Antibodies  >8 publications with GPBAR1 and Necrosis
 Carcinoma Antibodies  >7 publications with GPBAR1 and Carcinoma
 Liver Neoplasms Antibodies  >7 publications with GPBAR1 and Liver Neoplasms
 Gallstones Antibodies  >5 publications with GPBAR1 and Gallstones
 Cholestasis, Intrahepatic Antibodies  >4 publications with GPBAR1 and Cholestasis, Intrahepatic
 Fibrosis Antibodies  >4 publications with GPBAR1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >36 publications with GPBAR1 and Blood
 Connective Tissue Antibodies  >5 publications with GPBAR1 and Connective Tissue
 Brain Antibodies  >4 publications with GPBAR1 and Brain
 Lung Antibodies  >3 publications with GPBAR1 and Lung
 Nerve Antibodies  >2 publications with GPBAR1 and Nerve
 Skin Antibodies  >1 publications with GPBAR1 and Skin
 Placenta Antibodies  >1 publications with GPBAR1 and Placenta
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