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anti-GPR132 antibody :: Rabbit anti-Human GPR132 / G2A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242475
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GPR132 / G2A, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human GPR132 / G2A

 Product Synonym Names    Anti-GPR132 / G2A Antibody (Internal) IHC-plus; GPR132; G2A; G protein-coupled receptor 132; G protein-coupled receptor G2A; G2 accumulation protein; G2a receptor; Human GPR132; G2A
 Product Gene Name   

anti-GPR132 antibody

[Similar Products]
 Product Synonym Gene Name    G2A [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606167
 3D Structure    ModBase 3D Structure for Q9UNW8
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human GPR132 / G2A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 18 amino acid peptide from internal region of human GPR132 / G2A. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Marmoset (83%).
 Immunogen Type    Synthetic peptide
 Immunogen    GPR132 / G2A antibody was raised against synthetic 18 amino acid peptide from internal region of human GPR132 / G2A. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Marmoset (83%).
 Antigen Modification    Internal
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-GPR132 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GPR132 antibody

   G2A belongs to the Lysophospholipid/Lysosphingolipid Receptor family and is an anti-proliferative cell cycle regulator that plays a critical role in controlling peripheral lymphocyte homeostasis. Loss of G2A expression leads to the development of a late-onset autoimmune syndrome (Le et al, 2001). Lysophosphatidylcholine (LPC) is the activating ligand for G2A.
 Product Categories/Family for anti-GPR132 antibody    Family: GPCR
Subfamily: Lysophospholipid/Lysosphingolipid
 Applications Tested/Suitable for anti-GPR132 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-GPR132 antibody    ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubat...
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 Immunohistochemistry (IHC) of anti-GPR132 antibody    Anti-GPR132 / G2A antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPR132 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPR132 antibody    Anti-GPR132 / G2A antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-GPR132 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GPR132. It may not necessarily be applicable to this product.
 NCBI GI #    7019387
 NCBI GeneID    29933
 NCBI Accession #    NP_037477.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013345.3 [Other Products]
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 UniProt Primary Accession #    Q9UNW8 [Other Products]
 UniProt Secondary Accession #    Q9BSU2; A8K7X7; B4E144 [Other Products]
 UniProt Related Accession #    Q9UNW8 [Other Products]
 Molecular Weight    41,462 Da
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 NCBI Official Full Name    probable G-protein coupled receptor 132 isoform 1
 NCBI Official Synonym Full Names    G protein-coupled receptor 132
 NCBI Official Symbol    GPR132 [Similar Products]
 NCBI Official Synonym Symbols   
G2A
[Similar Products]
 NCBI Protein Information    probable G-protein coupled receptor 132; G2 accumulation protein
 UniProt Protein Name    Probable G-protein coupled receptor 132
 UniProt Synonym Protein Names   
G2 accumulation protein
 Protein Family    Probable G-protein coupled receptor
 UniProt Gene Name    GPR132 [Similar Products]
 UniProt Synonym Gene Names    G2A [Similar Products]
 UniProt Entry Name    GP132_HUMAN
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 NCBI Summary for GPR132    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for GPR132    GPR132: Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 14q32.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G1/S transition of mitotic cell cycle
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 Research Articles on GPR132    1. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GPR132 antibodyPathways associated with anti-GPR132 antibody
 Reference Product  PubMed Publications
 GPR4 antibody  >2 publications with GPR132 and GPR4
 GPR68 antibody  >2 publications with GPR132 and GPR68
 GPR65 antibody  >1 publications with GPR132 and GPR65
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with anti-GPR132 antibodyOrgans/Tissues associated with anti-GPR132 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with GPR132 and Inflammation
 Heart Diseases Antibodies  >1 publications with GPR132 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with GPR132 and Blood
 Intestine Antibodies  >1 publications with GPR132 and Intestine
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