O14842.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Free fatty acid receptor 1
NCBI Official Synonym Full Names
free fatty acid receptor 1
NCBI Protein Information
free fatty acid receptor 1
UniProt Protein Name
Free fatty acid receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor 40
UniProt Synonym Gene Names
UniProt Entry Name
FFAR1_HUMAN
NCBI Summary for FFAR1
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
UniProt Comments for FFAR1
FFAR1: Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: bioactive lipid receptor activity; G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; lipid binding
Biological Process: energy reserve metabolic process; G-protein coupled receptor protein signaling pathway; glucose homeostasis; insulin secretion; positive regulation of calcium ion transport; positive regulation of GTPase activity; positive regulation of insulin secretion; regulation of insulin secretion
Research Articles on FFAR1
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Pathways associated with anti-FFAR1 antibody
Diseases associated with anti-FFAR1 antibody
Organs/Tissues associated with anti-FFAR1 antibody
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