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anti-GPR44 antibody :: Rabbit GPR44 / CRTH2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS244950
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GPR44 / CRTH2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal (IgG) to Human GPR44 / CRTH2

 Product Synonym Names    Anti-GPR44 / CRTH2 Antibody (aa329-348) IHC-plus; PTGDR2; CD294; CRTH2; CD294 antigen; DP2; DL1R; G protein-coupled receptor 44; G-protein coupled receptor 44; HCRTH2; DP2 prostaglandin receptor; GPR44; Prostaglandin D2 receptor 2; Human GPR44; CRTH2
 Product Gene Name   

anti-GPR44 antibody

[Similar Products]
 Product Synonym Gene Name    CRTH2; PTGDR2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604837
 3D Structure    ModBase 3D Structure for Q9Y5Y4
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Gorilla, Human
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 Specificity    Residues 329-348 [DDSELGGAGSSRRRRTSSTA] of the CRTH2 (GPR44) protein. This sequence is near the C terminus.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human GPR44 / CRTH2. Percent identity by BLAST analysis: Human, Gorilla (100%); Pig (85%); Elephant (80%).
 Immunogen Type    Synthetic peptide
 Immunogen    GPR44 / CRTH2 antibody was raised against synthetic peptide from human GPR44 / CRTH2. Percent identity by BLAST analysis: Human, Gorilla (100%); Pig (85%); Elephant (80%).
 Antigen Modification    aa329-348
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-GPR44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GPR44 antibody

   GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.
 Product Categories/Family for anti-GPR44 antibody    Family: GPCR
Subfamily: Prostanoid
 Applications Tested/Suitable for anti-GPR44 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-GPR44 antibody    ELISA, IHC-P (10 ug/ml), WB (1:500 - 1:1000)
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 Immunohistochemistry (IHC) of anti-GPR44 antibody    Anti-GPR44 / CRTH2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-GPR44 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GPR44 antibody    Anti-GPR44 / CRTH2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-GPR44 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GPR44. It may not necessarily be applicable to this product.
 NCBI GI #    153791424
 NCBI GeneID    11251
 NCBI Accession #    NP_004769.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004778.2 [Other Products]
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 UniProt Primary Accession #    Q9Y5Y4 [Other Products]
 UniProt Secondary Accession #    O94765; Q4QRI6 [Other Products]
 UniProt Related Accession #    Q9Y5Y4 [Other Products]
 Molecular Weight    43,268 Da
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 NCBI Official Full Name    prostaglandin D2 receptor 2
 NCBI Official Synonym Full Names    prostaglandin D2 receptor 2
 NCBI Official Symbol    PTGDR2 [Similar Products]
 NCBI Official Synonym Symbols   
DP2; DL1R; CD294; CRTH2; GPR44
[Similar Products]
 NCBI Protein Information    prostaglandin D2 receptor 2; G protein-coupled receptor 44; G-protein coupled receptor 44; putative G-protein coupled receptor 44; chemoattractant receptor-homologous molecule expressed on TH2 cells; chemoattractant receptor homologous molecule expressed on T helper type 2 cells
 UniProt Protein Name    Prostaglandin D2 receptor 2
 UniProt Synonym Protein Names   
Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44; CD_antigen: CD294
 UniProt Gene Name    PTGDR2 [Similar Products]
 UniProt Synonym Gene Names    CRTH2; DL1R; GPR44 [Similar Products]
 UniProt Entry Name    PD2R2_HUMAN
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 NCBI Summary for GPR44    This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
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 UniProt Comments for GPR44    GPR44: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12-q13.3

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide binding; prostaglandin F receptor activity; prostaglandin J receptor activity; prostaglandin D receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; calcium-mediated signaling; immune response; G-protein signaling, adenylate cyclase inhibiting pathway; chemotaxis
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 Research Articles on GPR44    1. Data indicate that in ulcerative colitis, DP2 receptor showed higher expression in neutrophils but lower in monocytes, and CRTH2 receptor was decreased in eosinophils, NK, and CD3(+) T cells but not in monocytes and CD3(+)/CD4(+) T cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GPR44 antibodyPathways associated with anti-GPR44 antibody
 Reference Product  PubMed Publications
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 Prostanoid Ligand Receptors Pathway antibodies  Prostanoid Ligand Receptors Pathway Diagram
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