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anti-GPX3 antibody :: Goat GPX3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420423
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GPX3, Polyclonal Antibody

 Also Known As   

Goat anti-GPX3 Antibody

 Product Synonym Names    GPX3; glutathione peroxidase 3 (plasma); GPx-P; GSHPx-3; GSHPx-P; extracellular glutathione peroxidase; plasma glutathione peroxidase 3; GPX3 antibody; glutathione peroxidase 3 (plasma) antibody; GPx-P antibody; GSHPx-3 antibody; GSHPx-P antibody; extracellular glutathione peroxidase antibody; plasma glutathione peroxidase 3 antibody
 Product Gene Name   

anti-GPX3 antibody

[Similar Products]
 Antibody/Peptide Pairs    GPX3 peptide (MBS425753) is used for blocking the activity of GPX3 antibody (MBS420423)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    NQFGKQEPGE NSE
 OMIM    138321
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse, Pig; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-NQFGKQEPGENSE, from the internal region of the protein sequence according to NP_002075.2.
 Epitope    Internal region
 Note    This antibody may cross-react with epididymis-specific GPX5 and olfactory epithelium-speciific GPX6
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GPX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GPX3 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-GPX3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 1000.
Immunohistochemistry: Frozen sections of Porcin Kidney shows vesicular staining of the cytoplasm in PCT epithelial cells. Recommended concentration, 20ug/ml.
Western Blot: Approx 26kDa band observed in Mouse Kidney and Liver lysates (calculated MW of 27.7kDa according to Mouse NP_001077398.1 [isoform1], 25.4kDa according to Mouse NP_032187.2 [isoform 2] and 25.5kDa according to Human NP_002075.2). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-GPX3 antibody    (1ug/ml) staining of Mouse Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GPX3 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-GPX3 antibody    (20ug/ml) staining of PFA-perfused cryosection of Porcin Kidney. Microwave antigen retrieval with citrate buffer pH 3, CY3-staining. Data obtained from Dr. Hrvoje Brzica, University of Zagreb, Croatia
anti-GPX3 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for GPX3. It may not necessarily be applicable to this product.
 NCBI GI #    6006001
 NCBI GeneID    2878
 NCBI Accession #    NP_002075.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002084.3 [Other Products]
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 UniProt Secondary Accession #    O43787; Q86W78; Q9NZ74; Q9UEL1 [Other Products]
 UniProt Related Accession #    P22352 [Other Products]
 Molecular Weight    25,552 Da
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 NCBI Official Full Name    glutathione peroxidase 3
 NCBI Official Synonym Full Names    glutathione peroxidase 3
 NCBI Official Symbol    GPX3 [Similar Products]
 NCBI Official Synonym Symbols   
GPx-P; GSHPx-3; GSHPx-P
[Similar Products]
 NCBI Protein Information    glutathione peroxidase 3
 UniProt Protein Name    Glutathione peroxidase 3
 UniProt Synonym Protein Names   
Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GPx-P; GSHPx-P
 Protein Family    Probable glutathione peroxidase
 UniProt Gene Name    GPX3 [Similar Products]
 UniProt Synonym Gene Names    GPXP; GPx-3; GSHPx-3; GPx-P; GSHPx-P [Similar Products]
 UniProt Entry Name    GPX3_HUMAN
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 NCBI Summary for GPX3    This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GPX3    GPX3: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. Belongs to the glutathione peroxidase family.

Protein type: EC 1.11.1.9; Oxidoreductase; Lipid Metabolism - arachidonic acid; Secreted; Other Amino Acids Metabolism - glutathione; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: extracellular region; extracellular space

Molecular Function: glutathione peroxidase activity; protein binding; selenium binding; transcription factor binding

Biological Process: hydrogen peroxide catabolic process; protein homotetramerization; response to lipid hydroperoxide; response to reactive oxygen species
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 Research Articles on GPX3    1. Reduced GPX3 expression is associated with favorable/intermediate karyotypes but not with survival in de novo acute myeloid leukemia patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GPX3 antibodyPathways associated with anti-GPX3 antibody
 Reference Product  PubMed Publications
 TNF antibody  >12 publications with GPX3 and TNF
 SOD3 antibody  >11 publications with GPX3 and SOD3
 GSTP1 antibody  >10 publications with GPX3 and GSTP1
 GSTM3 antibody  >4 publications with GPX3 and GSTM3
 GSTO1 antibody  >3 publications with GPX3 and GSTO1
 GSTO2 antibody  >1 publications with GPX3 and GSTO2
 GSTT1 antibody  >1 publications with GPX3 and GSTT1
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
Diseases associated with anti-GPX3 antibodyOrgans/Tissues associated with anti-GPX3 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >31 publications with GPX3 and Cardiovascular Diseases
 Inflammation Antibodies  >28 publications with GPX3 and Inflammation
 Disease Models, Animal Antibodies  >21 publications with GPX3 and Disease Models, Animal
 Death Antibodies  >20 publications with GPX3 and Death
 Adenocarcinoma Antibodies  >19 publications with GPX3 and Adenocarcinoma
 Necrosis Antibodies  >18 publications with GPX3 and Necrosis
 Prostatic Neoplasms Antibodies  >13 publications with GPX3 and Prostatic Neoplasms
 Obesity Antibodies  >12 publications with GPX3 and Obesity
 Insulin Resistance Antibodies  >11 publications with GPX3 and Insulin Resistance
 Kidney Diseases Antibodies  >11 publications with GPX3 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >114 publications with GPX3 and Blood
 Liver Antibodies  >53 publications with GPX3 and Liver
 Kidney Antibodies  >36 publications with GPX3 and Kidney
 Muscle Antibodies  >28 publications with GPX3 and Muscle
 Lung Antibodies  >23 publications with GPX3 and Lung
 Thyroid Antibodies  >19 publications with GPX3 and Thyroid
 Prostate Antibodies  >19 publications with GPX3 and Prostate
 Heart Antibodies  >17 publications with GPX3 and Heart
 Brain Antibodies  >14 publications with GPX3 and Brain
 Adipose Tissue Antibodies  >12 publications with GPX3 and Adipose Tissue
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