NP_001500.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 25 kDa Predicted: 26 kDa
NCBI Official Full Name
epididymal secretory glutathione peroxidase isoform 1
NCBI Official Synonym Full Names
glutathione peroxidase 5
NCBI Official Synonym Symbols
NCBI Protein Information
epididymal secretory glutathione peroxidase
UniProt Protein Name
Epididymal secretory glutathione peroxidase
UniProt Synonym Protein Names
Epididymis-specific glutathione peroxidase-like protein; EGLP; Glutathione peroxidase 5; GPx-5; GSHPx-5
UniProt Synonym Gene Names
NCBI Summary for GPX5
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
UniProt Comments for GPX5
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Research Articles on GPX5
Precautions
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Disclaimer
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Pathways associated with anti-GPX5 antibody
Diseases associated with anti-GPX5 antibody
Disease Name |
Pubmed Publications |
Infertility, Male Antibodies |
>4 publications with GPX5 and Infertility, Male |
Neoplasms Antibodies |
>3 publications with GPX5 and Neoplasms |
Genital Diseases, Male Antibodies |
>3 publications with GPX5 and Genital Diseases, Male |
Neoplasms, Experimental Antibodies |
>2 publications with GPX5 and Neoplasms, Experimental |
Infertility, Female Antibodies |
>2 publications with GPX5 and Infertility, Female |
Drug Toxicity Antibodies |
>1 publications with GPX5 and Drug Toxicity |
Lung Diseases Antibodies |
>1 publications with GPX5 and Lung Diseases |
Hypertension Antibodies |
>1 publications with GPX5 and Hypertension |
Death Antibodies |
>1 publications with GPX5 and Death |
Cell Transformation, Neoplastic Antibodies |
>1 publications with GPX5 and Cell Transformation, Neoplastic |
Organs/Tissues associated with anti-GPX5 antibody
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