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anti-GRB10 antibody :: Rabbit GRB10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150671
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GRB10, Polyclonal Antibody

 Also Known As   

GRB10 Antibody

 Product Synonym Names    GRB10; RSS; IRBP; MEG1; GRB-IR; Grb-10; GRBIR; KIAA0207; Growth factor receptor-bound protein 10; GRB10 adapter protein; growth factor receptor-bound protein 10
 Product Gene Name   

anti-GRB10 antibody

[Similar Products]
 Antibody/Peptide Pairs    GRB10 peptide (MBS152893) is used for blocking the activity of GRB10 antibody (MBS150671)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601523
 3D Structure    ModBase 3D Structure for Q13322
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least three isoforms of GRB10 are known to exist; this antibody will detect all three isoforms.
 Purity/Purification    GRB10 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    GRB10 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human GRB10.
 Buffer    GRB10 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    GRB10 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-GRB10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GRB10 antibody

   GRB10 Antibody: GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts.
 Applications Tested/Suitable for anti-GRB10 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-GRB10 antibody    GRB10 antibody can be used for detection of GRB10 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunofluorescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-GRB10 antibody    Western blot analysis of GRB10 in SK-N-SH cell lysate with GRB10 antibody at (A) 1 and (B) 2 μg/mL.
anti-GRB10 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-GRB10 antibody    Immunofluorescence of GRB10 in rat brain cells with GRB10 antibody at 20 μg/mL.
anti-GRB10 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for GRB10. It may not necessarily be applicable to this product.
 NCBI GI #    48762679
 NCBI GeneID    2887
 NCBI Accession #    NP_005302 [Other Products]
 NCBI GenBank Nucleotide #    NM_005311.4 [Other Products]
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 UniProt Primary Accession #    Q13322 [Other Products]
 UniProt Secondary Accession #    O00427; O00701; O75222; Q92606; Q92907; Q92948; A4D258; A7VJ95; A8K0E6; D3DVM9 [Other Products]
 UniProt Related Accession #    Q13322 [Other Products]
 Molecular Weight    66,487 Da
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 NCBI Official Full Name    growth factor receptor-bound protein 10 isoform a
 NCBI Official Synonym Full Names    growth factor receptor-bound protein 10
 NCBI Official Symbol    GRB10 [Similar Products]
 NCBI Official Synonym Symbols   
RSS; IRBP; MEG1; GRB-IR; Grb-10
[Similar Products]
 NCBI Protein Information    growth factor receptor-bound protein 10; GRB10 adapter protein; GRB10 adaptor protein; maternally expressed gene 1; insulin receptor-binding protein Grb-IR
 UniProt Protein Name    Growth factor receptor-bound protein 10
 UniProt Synonym Protein Names   
GRB10 adapter protein; Insulin receptor-binding protein Grb-IR
 Protein Family    Growth factor receptor-bound protein
 UniProt Gene Name    GRB10 [Similar Products]
 UniProt Synonym Gene Names    GRBIR; KIAA0207 [Similar Products]
 UniProt Entry Name    GRB10_HUMAN
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 NCBI Summary for GRB10    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
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 UniProt Comments for GRB10    GRB10: an adaptor protein that inhibits insulin-stimulated IRS-PI (3)K-Akt signaling pathway by disrupting the association of IRS with the insulin receptor. Also binds activated PDGFR and EGFR. Preferentially localizes to the mitochondria, modulating the anti-apoptotic activity of mitochondrial Raf-1. Can translocate to the plasma membrane and lamellipodia. Three alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7p12.2

Cellular Component: cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity; insulin receptor binding

Biological Process: negative regulation of glucose import; negative regulation of Wnt receptor signaling pathway; insulin-like growth factor receptor signaling pathway; insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphorylation; response to insulin stimulus; negative regulation of glycogen biosynthetic process
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 Research Articles on GRB10    1. Tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GRB10 antibodyPathways associated with anti-GRB10 antibody
 Reference Product  PubMed Publications
 IGF1R antibody  >27 publications with GRB10 and IGF1R
 NEDD4 antibody  >8 publications with GRB10 and NEDD4
 AKT1 antibody  >6 publications with GRB10 and AKT1
 RET antibody  >5 publications with GRB10 and RET
 KIT antibody  >3 publications with GRB10 and KIT
 RAF1 antibody  >3 publications with GRB10 and RAF1
 GIGYF1 antibody  >3 publications with GRB10 and GIGYF1
 PDGFRB antibody  >1 publications with GRB10 and PDGFRB
 INSR antibody  >1 publications with GRB10 and INSR
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 IGF1 Pathway antibodies  IGF1 Pathway Diagram
 IRS Activation Pathway antibodies  IRS Activation Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 PDGFR-beta Signaling Pathway antibodies  PDGFR-beta Signaling Pathway Diagram
 SHC Activation Pathway antibodies  SHC Activation Pathway Diagram
Diseases associated with anti-GRB10 antibodyOrgans/Tissues associated with anti-GRB10 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >15 publications with GRB10 and Brain Diseases
 Nervous System Diseases Antibodies  >15 publications with GRB10 and Nervous System Diseases
 Fetal Growth Retardation Antibodies  >11 publications with GRB10 and Fetal Growth Retardation
 Disease Models, Animal Antibodies  >8 publications with GRB10 and Disease Models, Animal
 Breast Neoplasms Antibodies  >7 publications with GRB10 and Breast Neoplasms
 Weight Loss Antibodies  >5 publications with GRB10 and Weight Loss
 Carcinoma Antibodies  >5 publications with GRB10 and Carcinoma
 Cardiovascular Diseases Antibodies  >4 publications with GRB10 and Cardiovascular Diseases
 Cognition Disorders Antibodies  >3 publications with GRB10 and Cognition Disorders
 Kidney Diseases Antibodies  >3 publications with GRB10 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >32 publications with GRB10 and Brain
 Muscle Antibodies  >29 publications with GRB10 and Muscle
 Blood Antibodies  >27 publications with GRB10 and Blood
 Embryonic Tissue Antibodies  >23 publications with GRB10 and Embryonic Tissue
 Liver Antibodies  >18 publications with GRB10 and Liver
 Placenta Antibodies  >17 publications with GRB10 and Placenta
 Kidney Antibodies  >15 publications with GRB10 and Kidney
 Vascular Antibodies  >10 publications with GRB10 and Vascular
 Heart Antibodies  >9 publications with GRB10 and Heart
 Pancreas Antibodies  >9 publications with GRB10 and Pancreas
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