NP_079191.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 71kDa Molecular Weight: 625
NCBI Official Full Name
grainyhead-like protein 2 homolog
NCBI Official Synonym Full Names
grainyhead like transcription factor 2
NCBI Protein Information
grainyhead-like protein 2 homolog
UniProt Protein Name
Grainyhead-like protein 2 homolog
UniProt Synonym Protein Names
Brother of mammalian grainyhead; Transcription factor CP2-like 3
UniProt Synonym Gene Names
UniProt Entry Name
GRHL2_HUMAN
NCBI Summary for GRHL2
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009]
UniProt Comments for GRHL2
GRHL2: May function as a transcription factor. Defects in GRHL2 are the cause of deafness autosomal dominant type 28 (DFNA28). DFNA28 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA28 is characterized by mild to moderate hearing loss across most frequencies that progressed to severe loss in the higher frequencies by the fifth decade. Age at onset varied, with the earliest case documented at 7 years of age. Belongs to the grh/CP2 family. Grainyhead subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 8q22.3
Cellular Component: intercellular junction; nucleoplasm; nucleus; plasma membrane
Molecular Function: chromatin DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity
Biological Process: brain development; camera-type eye development; cell adhesion; cell proliferation; embryonic cranial skeleton morphogenesis; embryonic digit morphogenesis; epidermis development; multicellular organism growth; negative regulation of keratinocyte differentiation; neural tube closure; neural tube development; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Disease: Deafness, Autosomal Dominant 28; Ectodermal Dysplasia/short Stature Syndrome
Research Articles on GRHL2
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Diseases associated with anti-GRHL2 antibody
Organs/Tissues associated with anti-GRHL2 antibody
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