NP_000821.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,631 Da
NCBI Official Full Name
glutamate receptor ionotropic, kainate 1 isoform 1
NCBI Official Synonym Full Names
glutamate ionotropic receptor kainate type subunit 1
NCBI Official Synonym Symbols
EAA3; EEA3; GLR5; GLUR5; GluK1; gluR-5 [Similar Products]
NCBI Protein Information
glutamate receptor ionotropic, kainate 1
UniProt Protein Name
Glutamate receptor ionotropic, kainate 1
UniProt Synonym Protein Names
Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GluR5
UniProt Synonym Gene Names
NCBI Summary for GRIK1
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GRIK1
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
Research Articles on GRIK1
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Pathways associated with anti-GRIK1 antibody
Diseases associated with anti-GRIK1 antibody
Organs/Tissues associated with anti-GRIK1 antibody
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