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anti-GRIN1 antibody :: Rabbit GRIN1 / NMDAR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242755
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GRIN1 / NMDAR1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human GRIN1 / NMDAR1

 Product Synonym Names    Anti-GRIN1 / NMDAR1 Antibody (aa864-913) IHC-plus; GRIN1; GluN1; NMDAR1; NR1; MRD8; NMD-R1; NMDA receptor A1; NMDA1; NR1a; GluR zeta 1; Human GRIN1; NMDAR1
 Product Gene Name   

anti-GRIN1 antibody

[Similar Products]
 Product Synonym Gene Name    NMDAR1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614254
 3D Structure    ModBase 3D Structure for Q05586
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    NMDAR1 antibody detects endogenous levels of total NMDAR1 protein.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human NMDAR1 (aa864-913).
 Immunogen    GRIN1 / NMDAR1 antibody was raised against synthetic peptide from human NMDAR1 (aa864-913).
 Antigen Modification    aa864-913
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-GRIN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GRIN1 antibody

   Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR).
 Product Categories/Family for anti-GRIN1 antibody    Family: Ion Channel
Subfamily: Glutamate receptor - ionotropic (NMDA receptor)
 Applications Tested/Suitable for anti-GRIN1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-GRIN1 antibody    ELISA (1:20000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)
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 Immunohistochemistry (IHC) of anti-GRIN1 antibody    Anti-GRIN1 / NMDAR1 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-GRIN1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-GRIN1 antibody    Western blot of extracts from Jurkat cells, using NMDAR1 antibody. The lane on the right is treated with the synthesized peptide.
anti-GRIN1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GRIN1. It may not necessarily be applicable to this product.
 NCBI GI #    11038637
 NCBI GeneID    2902
 NCBI Accession #    NP_015566.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007327.3 [Other Products]
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 UniProt Primary Accession #    Q05586 [Other Products]
 UniProt Secondary Accession #    P35437; Q12867; Q12868; Q5VSF3; Q5VSF4; Q5VSF5; Q5VSF6; Q5VSF7; A6NLK7; A6NLR1; C9K0X1 [Other Products]
 UniProt Related Accession #    Q05586 [Other Products]
 Molecular Weight    101,851 Da
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 NCBI Official Full Name    glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, N-methyl D-aspartate 1
 NCBI Official Symbol    GRIN1 [Similar Products]
 NCBI Official Synonym Symbols   
NR1; MRD8; GluN1; NMDA1; NMD-R1; NMDAR1
[Similar Products]
 NCBI Protein Information    glutamate receptor ionotropic, NMDA 1; glutamate [NMDA] receptor subunit zeta 1; glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; N-methyl-D-aspartate receptor channel, subunit zeta-1
 UniProt Protein Name    Glutamate receptor ionotropic, NMDA 1
 UniProt Synonym Protein Names   
Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1
 Protein Family    Glutamate receptor ionotropic
 UniProt Gene Name    GRIN1 [Similar Products]
 UniProt Synonym Gene Names    NMDAR1; GluN1; NMD-R1 [Similar Products]
 UniProt Entry Name    NMDZ1_HUMAN
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 NCBI Summary for GRIN1    The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRIN1    NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: neuron projection; cell surface; integral to plasma membrane; endoplasmic reticulum; postsynaptic density; dendrite; dendritic spine; terminal button; excitatory synapse; N-methyl-D-aspartate selective glutamate receptor complex; postsynaptic membrane; synaptic vesicle; plasma membrane; synapse; cell junction

Molecular Function: voltage-gated cation channel activity; calmodulin binding; neurotransmitter binding; protein binding; glutamate receptor binding; enzyme binding; extracellular-glutamate-gated ion channel activity; glutamate binding; protein heterodimerization activity; calcium channel activity; N-methyl-D-aspartate selective glutamate receptor activity; glycine binding; calcium ion binding

Biological Process: regulation of long-term neuronal synaptic plasticity; axon guidance; male mating behavior; prepulse inhibition; adult locomotory behavior; positive regulation of apoptosis; regulation of dendrite morphogenesis; rhythmic process; response to morphine; regulation of axonogenesis; sensory perception of pain; calcium ion homeostasis; synaptic transmission; regulation of respiratory gaseous exchange; conditioned taste aversion; ephrin receptor signaling pathway; visual learning; negative regulation of neuron apoptosis; protein tetramerization; cation transport; synaptic transmission, glutamatergic; response to amphetamine; social behavior; respiratory gaseous exchange; pons maturation; cellular calcium ion homeostasis; regulation of membrane potential; response to ethanol; long-term memory; regulation of synaptogenesis; suckling behavior; olfactory learning; propylene metabolic process; ionotropic glutamate receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; regulation of excitatory postsynaptic membrane potential; response to calcium ion

Disease: Mental Retardation, Autosomal Dominant 8
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 Research Articles on GRIN1    1. Reduction in NR1 and NR2C in the DLPFC of people with schizophrenia may lead to altered NMDAR stoichiometry and provides compelling evidence for an endogenous NMDAR deficit in schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GRIN1 antibodyDiseases associated with anti-GRIN1 antibody
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >28 publications with GRIN1 and Nervous System Diseases
 Brain Diseases Antibodies  >17 publications with GRIN1 and Brain Diseases
 Disease Models, Animal Antibodies  >10 publications with GRIN1 and Disease Models, Animal
 Memory Disorders Antibodies  >8 publications with GRIN1 and Memory Disorders
 Nerve Degeneration Antibodies  >6 publications with GRIN1 and Nerve Degeneration
 Movement Disorders Antibodies  >5 publications with GRIN1 and Movement Disorders
 Pain Antibodies  >5 publications with GRIN1 and Pain
 Poisoning Antibodies  >4 publications with GRIN1 and Poisoning
 Depressive Disorder Antibodies  >4 publications with GRIN1 and Depressive Disorder
 Learning Disorders Antibodies  >4 publications with GRIN1 and Learning Disorders
Organs/Tissues associated with anti-GRIN1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >72 publications with GRIN1 and Brain
 Nerve Antibodies  >66 publications with GRIN1 and Nerve
 Eye Antibodies  >2 publications with GRIN1 and Eye
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