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anti-GRIN2D antibody :: Goat GRIN2D Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421593 anti-GRIN2D antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GRIN2D, Polyclonal Antibody

 Also Known As   

Goat anti-GRIN2D Antibody

 Product Synonym Names    GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; EB11; NMDAR2D; N-methyl-D-aspartate receptor subunit 2D; estrogen receptor binding CpG island; GRIN2D antibody; glutamate receptor; ionotropic; N-methyl D-aspartate 2D antibody; EB11 antibody; NMDAR2D antibody; N-methyl-D-aspartate receptor subunit 2D antibody; estrogen receptor binding CpG island antibody
 Product Gene Name   

anti-GRIN2D antibody

[Similar Products]
 Antibody/Peptide Pairs    GRIN2D peptide (MBS426937) is used for blocking the activity of GRIN2D antibody (MBS421593)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TRRGSAHFSS LESE
 OMIM    602717
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-TRRGSAHFSSLESE, from the C Terminus of the protein sequence according to NP_000827.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GRIN2D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GRIN2D antibody   

Peptide ELISA (EIA)

 Application Notes for anti-GRIN2D antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave an approx 80kDa band in Human Brain (Cerebellum) and in Mouse Brain and Rat Brain lysates after 0. 02ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 144kDa according to NP_000827.2. The 80kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for GRIN2D. It may not necessarily be applicable to this product.
 NCBI GI #    153946391
 NCBI GeneID    2906
 NCBI Accession #    NP_000827.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000836.2 [Other Products]
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 UniProt Related Accession #    O15399 [Other Products]
 Molecular Weight    143,752 Da
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 NCBI Official Full Name    glutamate receptor ionotropic, NMDA 2D
 NCBI Official Synonym Full Names    glutamate ionotropic receptor NMDA type subunit 2D
 NCBI Official Symbol    GRIN2D [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    glutamate receptor ionotropic, NMDA 2D
 UniProt Protein Name    Glutamate receptor ionotropic, NMDA 2D
 UniProt Synonym Protein Names   
EB11; Glutamate [NMDA] receptor subunit epsilon-4; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D
 Protein Family    Glutamate receptor ionotropic
 UniProt Gene Name    GRIN2D [Similar Products]
 UniProt Synonym Gene Names    GluN2D; NMDAR2D; GluN2D; NMDAR2D; NR2D [Similar Products]
 UniProt Entry Name    NMDE4_HUMAN
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 NCBI Summary for GRIN2D    N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]
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 UniProt Comments for GRIN2D    NMDAR2D: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cell junction; intracellular; N-methyl-D-aspartate selective glutamate receptor complex; plasma membrane; postsynaptic membrane

Molecular Function: extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: adult locomotory behavior; ionotropic glutamate receptor signaling pathway; MAPKKK cascade; positive regulation of GTPase activity; regulation of sensory perception of pain; signal transduction; startle response; synaptic transmission
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 Research Articles on GRIN2D    1. After 7 days of chronic alcohol exposure, there are significant increases in mRNA expression of GRIN2D in cultured neurons derived from alcoholic subjects, but not in cultures from nonalcoholics.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GRIN2D antibodyDiseases associated with anti-GRIN2D antibody
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >8 publications with GRIN2D and Schizophrenia
 Learning Disorders Antibodies  >3 publications with GRIN2D and Learning Disorders
 Depressive Disorder Antibodies  >2 publications with GRIN2D and Depressive Disorder
 Hyperkinesis Antibodies  >1 publications with GRIN2D and Hyperkinesis
 Disease Models, Animal Antibodies  >1 publications with GRIN2D and Disease Models, Animal
 Memory Disorders Antibodies  >1 publications with GRIN2D and Memory Disorders
 Cognition Disorders Antibodies  >1 publications with GRIN2D and Cognition Disorders
 Edema Antibodies  >1 publications with GRIN2D and Edema
 Seizures Antibodies  >1 publications with GRIN2D and Seizures
 Substance-Related Disorders Antibodies  >1 publications with GRIN2D and Substance-Related Disorders
Organs/Tissues associated with anti-GRIN2D antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with GRIN2D and Brain
 Embryonic Tissue Antibodies  >1 publications with GRIN2D and Embryonic Tissue
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