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anti-GSDMD antibody :: Rabbit GSDMD Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9130687
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GSDMD, Polyclonal Antibody

★Popular Item★
 Also Known As   

GSDMD Polyclonal Antibody

 Product Synonym Names    1810036L03Rik; AW558049; DF5L; Dfna5l; Gsdmdc1; M2-4
 Product Gene Name   

anti-GSDMD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS9130687 Technical Datasheet    Technical Datasheet PDF
 3D Structure    ModBase 3D Structure for Q9D8T2
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Immunogen    Recombinant protein of mouse GSDMD
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-GSDMD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-GSDMD antibody    Primary antibody
 Applications Tested/Suitable for anti-GSDMD antibody   

Western Blot (WB)

 Application Notes for anti-GSDMD antibody    WB: 1:500 - 1:2000
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 Western Blot (WB) of anti-GSDMD antibody    Western blot analysis of extracts of various cell lines, using GSDMD antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
anti-GSDMD antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GSDMD. It may not necessarily be applicable to this product.
 NCBI GI #    71152093
 NCBI GeneID    69146
 NCBI Accession #    Q9D8T2.1 [Other Products]
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 UniProt Primary Accession #    Q9D8T2 [Other Products]
 UniProt Secondary Accession #    Q3TBD9 [Other Products]
 UniProt Related Accession #    Q9D8T2 [Other Products]
 Molecular Weight    53kDa
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 NCBI Official Full Name    Gasdermin-D
 NCBI Official Synonym Full Names    gasdermin D
 NCBI Official Symbol    Gsdmd [Similar Products]
 NCBI Official Synonym Symbols   
DF5L; M2-4; Dfna5l; Gsdmdc1; AW558049; 1810036L03Rik
[Similar Products]
 NCBI Protein Information    gasdermin-D
 UniProt Protein Name    Gasdermin-D
 UniProt Synonym Protein Names   
Gasdermin domain-containing protein 1
 Protein Family    Gasdermin
 UniProt Gene Name    Gsdmdc1 [Similar Products]
 UniProt Synonym Gene Names    Gsdmd; GSDMD-CT [Similar Products]
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 UniProt Comments for GSDMD    FKSG10: Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 15|15 D3

Cellular Component: cytosol; extracellular space; nucleoplasm; plasma membrane

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding

Biological Process: cellular response to extracellular stimulus; cytolysis; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; pore complex biogenesis; positive regulation of interleukin-1 beta secretion; protein homooligomerization
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 Research Articles on GSDMD    1. Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta in both canonical and non-canonical inflammasome responses.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GSDMD antibodyPathways associated with anti-GSDMD antibody
 Reference Product  PubMed Publications
 Casp1 antibody  >15 publications with GSDMD and Casp1
 Nlrp3 antibody  >5 publications with GSDMD and Nlrp3
 Aim2 antibody  >1 publications with GSDMD and Aim2
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 NOD-like Receptor Signaling Pathway antibodies  NOD-like Receptor Signaling Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
Diseases associated with anti-GSDMD antibodyOrgans/Tissues associated with anti-GSDMD antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with GSDMD and Inflammation
 Necrosis Antibodies  >9 publications with GSDMD and Necrosis
 Fatty Liver Antibodies  >1 publications with GSDMD and Fatty Liver
 Weight Loss Antibodies  >1 publications with GSDMD and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >3 publications with GSDMD and Skin
 Bone Antibodies  >2 publications with GSDMD and Bone
 Bone Marrow Antibodies  >2 publications with GSDMD and Bone Marrow
 Joint Antibodies  >1 publications with GSDMD and Joint
 Stomach Antibodies  >1 publications with GSDMD and Stomach
 Liver Antibodies  >1 publications with GSDMD and Liver
 Intestine Antibodies  >1 publications with GSDMD and Intestine
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