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anti-GSTM1 antibody :: Goat GSTM1/GSTM2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420063
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GSTM1/GSTM2, Polyclonal Antibody

 Also Known As   

Goat anti-GSTM1/GSTM2 Antibody

 Product Synonym Names    GSTM1; GSTM2; MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b; glutathione S-transferase M1; HB subunit 4; GST class-mu 1; glutathione S-aryltransferase; glutathione S-alkyltransferase; glutathione S-transferase, Mu-1; glutathione; GSTM1 antibody; GSTM2 antibody; MU antibody; H-B antibody; GST1 antibody; GTH4 antibody; GTM1 antibody; MU-1 antibody; GSTM1-1 antibody; MGC26563 antibody; GSTM1a-1a antibody; GSTM1b-1b antibody; glutathione S-transferase M1 antibody; HB subunit 4 antibody; GST class-mu 1 antibody; glutathione S-aryltransferase antibody; glutathione S-alkyltransferase antibody; glutathione S-transferase; Mu-1 antibody; glutathione S-aralkyltransferase antibody; S-(hydroxyalkyl)glutathione lyase antibody; glutathione S-transferase mu 1 antibody; glutathione S-transferase mu 2 (muscle) antibody; GST4 antibody; GSTM antibody; GSTM2-2 antibody; GTHMUS antibody; MGC117303 antibody; GST class-mu 2 antibody; GST; muscle antibody; S-(hydroxyalkyl)glutathione lyase M2 antibody; glutathione S-alkyltransferase M2 antibody; glutathione S-aralkyltransferase M2 antibody; glutathione S-aryltransferase M2 antibody; glutathione S-transferase 4 antibody; glutathione S-transferase M1 antibody; glutathione S-transferase M2 (muscle) antibody; glutathione S-transferase mu 2 antibody; GSTM1 / GSTM2
 Product Gene Name   

anti-GSTM1 antibody

[Similar Products]
 Product Synonym Gene Name    GSTM2 [Similar Products]
 Antibody/Peptide Pairs    GSTM1 / GSTM2 peptide (MBS425838) is used for blocking the activity of GSTM1/GSTM2 antibody (MBS420063)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    CVFSKMAVWG NK
 OMIM    138350
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence CVFSKMAVWGNK, from the C Terminus of the protein sequence according to NP_000552.2; NP_666533.1; NP_000839.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise both reported variants of human GSTM1 protein (NP_000552.2; NP_666533.1) and wil also recognise human GSTM2 protein (NP_000839.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GSTM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GSTM1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-GSTM1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Approx 26kDa band observed in Human Liver and Human Lung lysates (calculated MW of 25.7kDa according to NP_000552.2, and NP_000839.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-GSTM1 antibody    (0.3ug/ml) staining of Human Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GSTM1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GSTM1. It may not necessarily be applicable to this product.
 NCBI GI #    23065544
 NCBI GeneID    2944
 NCBI Accession #    NP_000552.2 [Other Products]
 NCBI Related Accession #    NP_666533.1; NP_000839.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000561.3 [Other Products]
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 UniProt Secondary Accession #    Q5GHG0; Q6FH88; Q8TC98; Q9UC96 [Other Products]
 UniProt Related Accession #    P09488 [Other Products]
 Molecular Weight    21,253 Da
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 NCBI Official Full Name    glutathione S-transferase Mu 1 isoform 1
 NCBI Official Synonym Full Names    glutathione S-transferase mu 1
 NCBI Official Symbol    GSTM1 [Similar Products]
 NCBI Official Synonym Symbols   
MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; GSTM1a-1a; GSTM1b-1b
[Similar Products]
 NCBI Protein Information    glutathione S-transferase Mu 1
 UniProt Protein Name    Glutathione S-transferase Mu 1
 UniProt Synonym Protein Names   
GST HB subunit 4; GST class-mu 1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GTH4
 Protein Family    Glutathione S-transferase
 UniProt Gene Name    GSTM1 [Similar Products]
 UniProt Synonym Gene Names    GST1 [Similar Products]
 UniProt Entry Name    GSTM1_HUMAN
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 NCBI Summary for GSTM1    Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GSTM1    GSTM1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Mu family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Other Amino Acids Metabolism - glutathione; EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Transferase

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: cytoplasm; cytosol

Molecular Function: enzyme binding; glutathione binding; glutathione transferase activity; protein homodimerization activity

Biological Process: glutathione metabolic process; nitrobenzene metabolic process; xenobiotic catabolic process
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 Research Articles on GSTM1    1. Meta-analysis revealed slight increase of Parkinson's disease risk in GSTM1 null genotype in subgroup analysis of ethnicity, publication year and sample size of total cases; short of statistical significance was detected for GSTT1 null genotype
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GSTM1 antibodyPathways associated with anti-GSTM1 antibody
 Reference Product  PubMed Publications
 GSTT1 antibody  >2251 publications with GSTM1 and GSTT1
 CYP1A1 antibody  >662 publications with GSTM1 and CYP1A1
 CYP2E1 antibody  >284 publications with GSTM1 and CYP2E1
 EPHX1 antibody  >160 publications with GSTM1 and EPHX1
 GSTM3 antibody  >134 publications with GSTM1 and GSTM3
 CYP1B1 antibody  >83 publications with GSTM1 and CYP1B1
 CYP1A2 antibody  >74 publications with GSTM1 and CYP1A2
 GSTM2 antibody  >36 publications with GSTM1 and GSTM2
 GSTA4 antibody  >19 publications with GSTM1 and GSTA4
 MAP3K5 antibody  >2 publications with GSTM1 and MAP3K5
 Products by Pathway  Pathway Diagram
 Aflatoxin B1 Metabolism Pathway antibodies  Aflatoxin B1 Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Estrogen Metabolism Pathway antibodies  Estrogen Metabolism Pathway Diagram
 Glutathione Conjugation Pathway antibodies  Glutathione Conjugation Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
Diseases associated with anti-GSTM1 antibodyOrgans/Tissues associated with anti-GSTM1 antibody
 Disease Name  Pubmed Publications
 Disease Susceptibility Antibodies  >1345 publications with GSTM1 and Disease Susceptibility
 Genetic Predisposition to Disease Antibodies  >1191 publications with GSTM1 and Genetic Predisposition to Disease
 Lung Neoplasms Antibodies  >329 publications with GSTM1 and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >230 publications with GSTM1 and Carcinoma, Squamous Cell
 Skin Diseases Antibodies  >220 publications with GSTM1 and Skin Diseases
 Colorectal Neoplasms Antibodies  >155 publications with GSTM1 and Colorectal Neoplasms
 Leukemia Antibodies  >154 publications with GSTM1 and Leukemia
 Liver Diseases Antibodies  >145 publications with GSTM1 and Liver Diseases
 Urinary Bladder Neoplasms Antibodies  >133 publications with GSTM1 and Urinary Bladder Neoplasms
 Chromosome Aberrations Antibodies  >129 publications with GSTM1 and Chromosome Aberrations
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >479 publications with GSTM1 and Lung
 Liver Antibodies  >218 publications with GSTM1 and Liver
 Bladder Antibodies  >179 publications with GSTM1 and Bladder
 Stomach Antibodies  >91 publications with GSTM1 and Stomach
 Prostate Antibodies  >90 publications with GSTM1 and Prostate
 Kidney Antibodies  >67 publications with GSTM1 and Kidney
 Brain Antibodies  >59 publications with GSTM1 and Brain
 Heart Antibodies  >51 publications with GSTM1 and Heart
 Bone Antibodies  >50 publications with GSTM1 and Bone
 Eye Antibodies  >30 publications with GSTM1 and Eye
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