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anti-Gab 1 antibody :: Rabbit Gab 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9400798
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Gab 1, Polyclonal Antibody

 Also Known As   

Gab 1 (Phospho-Tyr659) Polyclonal Antibody

 Product Synonym Names    GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1
 Product Gene Name   

anti-Gab 1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604439
 3D Structure    ModBase 3D Structure for Q13480
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Phospho-Gab 1 (Y659) Polyclonal Antibody detects endogenous levels of Gab 1 protein only when phosphorylated at Y659.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Immunogen Type    peptide
 Immunogen Description    Synthesized peptide derived from human Gab 1 around the phosphorylation site of Y659.
 Modification    Phospho-Tyr659
 Target Species    Human
 Target Name    Gab 1
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-Gab 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Gab 1 antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-Gab 1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-Gab 1 antibody    Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:100 - 1:300
Immunofluorescence: 1:200 - 1:1000
ELISA: 1:5000
Not yet tested in other applications
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 Western Blot (WB) of anti-Gab 1 antibody    Western Blot analysis of 3T3 cells using Phospho-Gab 1 (Y659) Polyclonal Antibody
anti-Gab 1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Gab 1. It may not necessarily be applicable to this product.
 NCBI GI #    46370073
 NCBI GeneID    2549
 NCBI Accession #    NP_002030.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002039.3 [Other Products]
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 UniProt Primary Accession #    Q13480 [Other Products]
 UniProt Secondary Accession #    Q4W5G2; Q6P1W2; A8K152 [Other Products]
 UniProt Related Accession #    Q13480 [Other Products]
 Molecular Weight    80,005 Da
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 NCBI Official Full Name    GRB2-associated-binding protein 1 isoform b
 NCBI Official Synonym Full Names    GRB2-associated binding protein 1
 NCBI Official Symbol    GAB1 [Similar Products]
 NCBI Protein Information    GRB2-associated-binding protein 1
 UniProt Protein Name    GRB2-associated-binding protein 1
 UniProt Synonym Protein Names   
GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1
 UniProt Gene Name    GAB1 [Similar Products]
 UniProt Entry Name    GAB1_HUMAN
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 NCBI Summary for Gab 1    The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for Gab 1    GAB1: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. Belongs to the GAB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q31.21

Cellular Component: cytosol

Molecular Function: signal transducer activity; protein binding; SH3/SH2 adaptor activity

Biological Process: epidermal growth factor receptor signaling pathway; cell proliferation; epidermis development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; heart development; insulin receptor signaling pathway; innate immune response; platelet-derived growth factor receptor signaling pathway; response to oxidative stress; regulation of cell migration; activation of JNK activity
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 Research Articles on Gab 1    1. Studied the pleckstrin homology (PH) domain of GAB1 for cancer treatment. Using homology models we derived, high-throughput virtual screening of five million compounds resulted in five hits which exhibited strong binding affinities to GAB1 PH domain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Gab 1 antibodyPathways associated with anti-Gab 1 antibody
 Reference Product  PubMed Publications
 GRB2 antibody  >208 publications with Gab 1 and GRB2
 MET antibody  >104 publications with Gab 1 and MET
 PTPN11 antibody  >70 publications with Gab 1 and PTPN11
 EGFR antibody  >60 publications with Gab 1 and EGFR
 SOS1 antibody  >15 publications with Gab 1 and SOS1
 FRS2 antibody  >12 publications with Gab 1 and FRS2
 SHC1 antibody  >10 publications with Gab 1 and SHC1
 CRKL antibody  >6 publications with Gab 1 and CRKL
 GRAP2 antibody  >2 publications with Gab 1 and GRAP2
 PIK3R1 antibody  >1 publications with Gab 1 and PIK3R1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Constitutive Signaling By EGFRvIII Pathway antibodies  Constitutive Signaling By EGFRvIII Pathway Diagram
 Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway antibodies  Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with anti-Gab 1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >18 publications with Gab 1 and Cardiovascular Diseases
 Lung Diseases Antibodies  >17 publications with Gab 1 and Lung Diseases
 Breast Neoplasms Antibodies  >15 publications with Gab 1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >14 publications with Gab 1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >13 publications with Gab 1 and Neoplasms, Experimental
 Inflammation Antibodies  >13 publications with Gab 1 and Inflammation
 Vascular Diseases Antibodies  >13 publications with Gab 1 and Vascular Diseases
 Disease Models, Animal Antibodies  >12 publications with Gab 1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >9 publications with Gab 1 and Nervous System Diseases
 Necrosis Antibodies  >8 publications with Gab 1 and Necrosis
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