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anti-GLa antibody :: Rabbit anti-Mouse Galactosidase Alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2026025 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $315 +1 FREE 8GB USB
1 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Galactosidase Alpha (GLa), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Galactosidase Alpha (GLa)

 Product Gene Name   

anti-GLa antibody

[Similar Products]
 Matching Pairs    Antibody: Galactosidase Alpha (MBS2026025)
Antigen: Galactosidase Alpha (MBS2029568)
 Matching Pairs    Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
APC: Galactosidase Alpha (GLa) (MBS2039276)
 Matching Pairs    Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
PE Conjugated Antibody: Galactosidase Alpha (GLa) (MBS2039277)
 Matching Pairs    Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
APC: Galactosidase Alpha (GLa) (MBS2039278)
 Matching Pairs    Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
Cy3 Conjugated Antibody: Galactosidase Alpha (GLa) (MBS2039279)
 Matching Pairs    Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
FITC Conjugated Antibody: Galactosidase Alpha (GLa) (MBS2039280)
 Matching Pairs    Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
HRP Conjugated Antibody: Galactosidase Alpha (GLa) (MBS2039281)
 Matching Pairs    Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
APC: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Galactosidase Alpha (MBS2026025)
Biotin Conjugated Antibody: Galactosidase Alpha (GLa) (MBS2091677)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P51569
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Specificity    The antibody is a rabbit polyclonal antibody raised against GLa. It has beenselected for its ability to recognize GLa in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    GLa (Val29~Gly258)
 Organism Species    Mus musculus (Mouse)
 Conjugate    No Conjugate
 Immunogen    Recombinant GLa (Val29~Gly258) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2039278
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-GLa antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GLa antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-GLa antibody    Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-GLa antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-GLa antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GLa antibody    (DAB staining on IHC-P; Samples: Mouse Testis Tissue)
anti-GLa antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GLa antibody    (Used in DAB staining on formalin fixed paraffin-embedded Kidney tissue)
anti-GLa antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GLa. It may not necessarily be applicable to this product.
 NCBI GI #    1703210
 NCBI GeneID    11605
 NCBI Accession #    P51569.1 [Other Products]
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 UniProt Primary Accession #    P51569 [Other Products]
 UniProt Related Accession #    P51569 [Other Products]
 Molecular Weight    47,643 Da
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 NCBI Official Full Name    Alpha-galactosidase A
 NCBI Official Synonym Full Names    galactosidase, alpha
 NCBI Official Symbol    Gla [Similar Products]
 NCBI Official Synonym Symbols   
Ags
[Similar Products]
 NCBI Protein Information    alpha-galactosidase A
 UniProt Protein Name    Alpha-galactosidase A
 UniProt Synonym Protein Names   
Alpha-D-galactosidase A; Alpha-D-galactoside galactohydrolase; Melibiase
 Protein Family    Glycerol facilitator-aquaporin
 UniProt Gene Name    Gla [Similar Products]
 UniProt Synonym Gene Names    Ags [Similar Products]
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 UniProt Comments for GLa    GLA: Defects in GLA are the cause of Fabry disease (FD). FD is a rare X-linked sphingolipidosis disease where glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaoslyceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Clinical recognition in males results from characteristic skin lesions (angiokeratomas) over the lower trunk. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease. Heterozygous females may exhibit the disorder in an attenuated form, they are more likely to show corneal opacities. Belongs to the glycosyl hydrolase 27 family.

Protein type: Carbohydrate Metabolism - galactose; EC 3.2.1.22; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Hydrolase; Lipid Metabolism - glycerolipid; Lipid Metabolism - sphingolipid

Chromosomal Location of Human Ortholog: X E3|X 56.2 cM

Cellular Component: cytoplasm; extracellular region; extracellular space; Golgi apparatus; lysosome

Molecular Function: alpha-galactosidase activity; catalytic activity; galactoside binding; hydrolase activity; hydrolase activity, acting on glycosyl bonds; hydrolase activity, hydrolyzing O-glycosyl compounds; protein homodimerization activity; receptor binding

Biological Process: bone mineralization; carbohydrate metabolic process; glycoside catabolic process; glycosylceramide catabolic process; metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of nitric-oxide synthase activity; oligosaccharide metabolic process
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 Research Articles on GLa    1. Mice with alpha-galactosidase A deficiency show age-dependent and distinct deficits of the sensory system.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GLa antibodyOrgans/Tissues associated with anti-GLa antibody
 Products by Pathway  Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1895 publications with GLa and Blood
 Brain Antibodies  >464 publications with GLa and Brain
 Kidney Antibodies  >328 publications with GLa and Kidney
 Skin Antibodies  >165 publications with GLa and Skin
 Lung Antibodies  >130 publications with GLa and Lung
 Eye Antibodies  >113 publications with GLa and Eye
 Intestine Antibodies  >90 publications with GLa and Intestine
 Embryonic Tissue Antibodies  >74 publications with GLa and Embryonic Tissue
 Spinal Cord Antibodies  >71 publications with GLa and Spinal Cord
 Bone Marrow Antibodies  >58 publications with GLa and Bone Marrow
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