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anti-GABARAP antibody :: Rabbit anti-Human Gamma-aminobutyric acid receptor-associated protein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS715566
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Gamma-aminobutyric acid receptor-associated protein (GABARAP), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Gamma-aminobutyric acid receptor-associated protein polyclonal Antibody, Biotin conjugated

 Product Gene Name   

anti-GABARAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605125
 3D Structure    ModBase 3D Structure for O95166
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant human Gamma-aminobutyric acid receptor-associated protein protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9189 / sc-9190 / sc-28938
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GABARAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GABARAP antibody

   May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton
 Applications Tested/Suitable for anti-GABARAP antibody   

ELISA (EIA)

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 Western Blot (WB) of anti-GABARAP antibody    Western blot All lanes: Casein kinase II subunit beta antibody at at 2 /mlLane 1: EC109 whole cell lysateLane 2: 293T whole cell lysate SecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilution Predicted band size: 13 kDa Observed band size: 80 kDa Why is the actual band size different from the predicted Western blotting is a technique that separates proteins based on size - in general, the smaller the protein the faster it migrates through the gel. However, migration is also affected by other factors and so the actual band size observed may differ from that predicted. Common factors include... post-translational modification - e.g. phosphorylation, glycosylation etc which increases the size of the protein post-translation cleavage - e.g. many proteins are synthesized as pro-proteins, and then cleaved to give the active form, e.g. pro-caspases splice variants - alternative splicing may create different sized proteins from the same gene relative charge - the composition of amino acids (charged vs non-charged) multimers - e.g. dimerisation of a protein. This is usually prevented in reducing conditions, although strong interactions can result in the appearance of higher bands.
anti-GABARAP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GABARAP. It may not necessarily be applicable to this product.
 NCBI GI #    6005764
 NCBI GeneID    11337
 NCBI Accession #    NP_009209.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007278.1 [Other Products]
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 UniProt Primary Accession #    O95166 [Other Products]
 UniProt Related Accession #    O95166 [Other Products]
 Molecular Weight    13,918 Da [Similar Products]
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 NCBI Official Full Name    gamma-aminobutyric acid receptor-associated protein
 NCBI Official Synonym Full Names    GABA(A) receptor-associated protein
 NCBI Official Symbol    GABARAP [Similar Products]
 NCBI Official Synonym Symbols   
MM46; ATG8A; GABARAP-a
[Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor-associated protein
 UniProt Protein Name    Gamma-aminobutyric acid receptor-associated protein
 UniProt Synonym Protein Names   
GABA(A) receptor-associated protein; MM46
 Protein Family    Gamma-aminobutyric acid receptor-associated protein
 UniProt Gene Name    GABARAP [Similar Products]
 UniProt Synonym Gene Names    FLC3B [Similar Products]
 UniProt Entry Name    GBRAP_HUMAN
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 NCBI Summary for GABARAP    Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GABARAP    GABARAP: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Belongs to the MAP1 LC3 family. Interacts with GPHN and NSF. Interacts with GABRG2, beta-tubulin and ULK1.

Protein type: Vesicle; Adaptor/scaffold; Microtubule-binding; Autophagy; Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: actin cytoskeleton; autophagic vacuole; axoneme; cytoplasmic vesicle; cytosol; Golgi membrane; lysosome; microtubule; microtubule associated complex; perinuclear region of cytoplasm; plasma membrane; smooth endoplasmic reticulum

Molecular Function: beta-tubulin binding; GABA receptor binding; microtubule binding; protein binding; ubiquitin protein ligase binding

Biological Process: induction of apoptosis via death domain receptors; macroautophagy; microtubule cytoskeleton organization and biogenesis; protein targeting; synaptic transmission
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 Research Articles on GABARAP    1. The interaction of GABARAP with Mulan-Ube2E3 supports the role of Mulan as an important regulator of mitophagy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GABARAP antibodyPathways associated with anti-GABARAP antibody
 Reference Product  PubMed Publications
 ATG3 antibody  >16 publications with GABARAP and ATG3
 SQSTM1 antibody  >15 publications with GABARAP and SQSTM1
 ATG7 antibody  >15 publications with GABARAP and ATG7
 ATG4B antibody  >11 publications with GABARAP and ATG4B
 NSF antibody  >8 publications with GABARAP and NSF
 ULK1 antibody  >7 publications with GABARAP and ULK1
 BNIP3L antibody  >4 publications with GABARAP and BNIP3L
 NBR1 antibody  >4 publications with GABARAP and NBR1
 GABRG2 antibody  >3 publications with GABARAP and GABRG2
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Macroautophagy Pathway antibodies  Macroautophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Regulation Of Autophagy Pathway antibodies  Regulation Of Autophagy Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with anti-GABARAP antibodyOrgans/Tissues associated with anti-GABARAP antibody
 Disease Name  Pubmed Publications
 Death Antibodies  >17 publications with GABARAP and Death
 Atrophy Antibodies  >6 publications with GABARAP and Atrophy
 Chromosome Aberrations Antibodies  >4 publications with GABARAP and Chromosome Aberrations
 Breast Neoplasms Antibodies  >4 publications with GABARAP and Breast Neoplasms
 Abnormalities, Multiple Antibodies  >2 publications with GABARAP and Abnormalities, Multiple
 Necrosis Antibodies  >2 publications with GABARAP and Necrosis
 Learning Disorders Antibodies  >1 publications with GABARAP and Learning Disorders
 Hypertrophy Antibodies  >1 publications with GABARAP and Hypertrophy
 Inflammation Antibodies  >1 publications with GABARAP and Inflammation
 Drug-Induced Liver Injury Antibodies  >1 publications with GABARAP and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >50 publications with GABARAP and Brain
 Kidney Antibodies  >13 publications with GABARAP and Kidney
 Nerve Antibodies  >13 publications with GABARAP and Nerve
 Muscle Antibodies  >11 publications with GABARAP and Muscle
 Liver Antibodies  >11 publications with GABARAP and Liver
 Blood Antibodies  >11 publications with GABARAP and Blood
 Heart Antibodies  >8 publications with GABARAP and Heart
 Spinal Cord Antibodies  >7 publications with GABARAP and Spinal Cord
 Embryonic Tissue Antibodies  >6 publications with GABARAP and Embryonic Tissue
 Eye Antibodies  >4 publications with GABARAP and Eye
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