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anti-GSN antibody :: Goat Gelsolin/GSN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420495
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Gelsolin/GSN, Polyclonal Antibody

 Also Known As   

Goat anti-Gelsolin/GSN Antibody

 Product Synonym Names    Goat Anti-Gelsolin (isoform a) Antibody; GSN; gelsolin; gelsolin (amyloidosis, Finnish type); DKFZp313L0718; GSN antibody; gelsolin antibody; gelsolin (amyloidosis; Finnish type) antibody; DKFZp313L0718 antibody; Gelsolin; Gelsolin / GSN
 Product Gene Name   

anti-GSN antibody

[Similar Products]
 Antibody/Peptide Pairs    Gelsolin / GSN peptide (MBS425251) is used for blocking the activity of Gelsolin/GSN antibody (MBS420495)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PRLKDKKMDA HP
 OMIM    105120
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PRLKDKKMDAHP, from the internal region of the protein sequence according to NP_000168.1; NP_937895.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize both reported isoforms (NP_000168.1 and NP_937895.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GSN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GSN antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-GSN antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 90kDa band observed in Human Spleen lysates (calculated MW of 85.7kDa according to NP_000168.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-GSN antibody    (0.1ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GSN antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GSN. It may not necessarily be applicable to this product.
 NCBI GI #    4504165
 NCBI GeneID    2934
 NCBI Accession #    NP_000168.1 [Other Products]
 NCBI Related Accession #    NP_937895.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000177.4 [Other Products]
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 UniProt Secondary Accession #    Q5T0I2; Q8WVV7; A2A418; A8MUD1; A8MYN7; B7Z373; B7Z5V1; F5H1A8 [Other Products]
 UniProt Related Accession #    P06396 [Other Products]
 Molecular Weight    81,485 Da
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 NCBI Official Full Name    gelsolin isoform a
 NCBI Official Synonym Full Names    gelsolin
 NCBI Official Symbol    GSN [Similar Products]
 NCBI Official Synonym Symbols   
ADF; AGEL
[Similar Products]
 NCBI Protein Information    gelsolin
 UniProt Protein Name    Gelsolin
 UniProt Synonym Protein Names   
AGEL; Actin-depolymerizing factor; ADF; Brevin
 UniProt Gene Name    GSN [Similar Products]
 UniProt Synonym Gene Names    ADF [Similar Products]
 UniProt Entry Name    GELS_HUMAN
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 NCBI Summary for GSN    The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GSN    Gelsolin: a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Its expression is significantly decreased in many tumors and transformed cell lines. Gelsolin and other proteins including E-cadherin, BRCA, p21WAF, HoxA5, and retinoic acid receptor II are regulated by epigenetic changes in breast cancers. Gelsolin helps mediate the ability of HDAC inhibitors to protect neurons from oxygen/glucose deprivation. Two human isoforms are produced by alternative initiation.

Protein type: Secreted; Actin-binding; Secreted, signal peptide; Motility/polarity/chemotaxis; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: actin cap; actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytosol; extracellular region; extracellular space; focal adhesion; lamellipodium; myelin sheath; nucleus; perinuclear region of cytoplasm; plasma membrane; podosome; ruffle; sarcoplasm

Molecular Function: actin binding; calcium ion binding; myosin II binding; protein binding; protein domain specific binding

Biological Process: actin filament capping; actin filament polymerization; actin filament severing; actin nucleation; aging; barbed-end actin filament capping; cellular protein metabolic process; extracellular matrix disassembly; negative regulation of virion penetration into host cell; oligodendrocyte development; phagocytosis, engulfment; phosphoinositide-mediated signaling; positive regulation of actin nucleation; protein destabilization; response to ethanol; response to folic acid; sequestering of actin monomers; striated muscle atrophy; tissue regeneration

Disease: Amyloidosis, Finnish Type
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 Research Articles on GSN    1. GSNs might play a regulatory role in the suppression of the tissue damage induced by acute radiation exposure
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GSN antibodyPathways associated with anti-GSN antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >9 publications with GSN and CASP3
 APP antibody  >8 publications with GSN and APP
 ACTA1 antibody  >2 publications with GSN and ACTA1
 TTR antibody  >1 publications with GSN and TTR
 SRC antibody  >1 publications with GSN and SRC
 Products by Pathway  Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 EGF Receptor (ErbB1) Signaling Pathway antibodies  EGF Receptor (ErbB1) Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
Diseases associated with anti-GSN antibodyOrgans/Tissues associated with anti-GSN antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >32 publications with GSN and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >14 publications with GSN and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >10 publications with GSN and Adenocarcinoma
 Inflammation Antibodies  >9 publications with GSN and Inflammation
 Liver Diseases Antibodies  >8 publications with GSN and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with GSN and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >8 publications with GSN and Liver Neoplasms
 Necrosis Antibodies  >5 publications with GSN and Necrosis
 Neoplasms, Experimental Antibodies  >5 publications with GSN and Neoplasms, Experimental
 Lung Diseases Antibodies  >5 publications with GSN and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >46 publications with GSN and Blood
 Brain Antibodies  >46 publications with GSN and Brain
 Nerve Antibodies  >35 publications with GSN and Nerve
 Bone Antibodies  >17 publications with GSN and Bone
 Muscle Antibodies  >16 publications with GSN and Muscle
 Liver Antibodies  >13 publications with GSN and Liver
 Heart Antibodies  >11 publications with GSN and Heart
 Vascular Antibodies  >10 publications with GSN and Vascular
 Lung Antibodies  >8 publications with GSN and Lung
 Skin Antibodies  >7 publications with GSN and Skin
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