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anti-GHRL antibody :: Goat Ghrelin preproprotein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421239
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ghrelin preproprotein (GHRL), Polyclonal Antibody

 Also Known As   

Goat anti-Ghrelin preproprotein Antibody

 Product Synonym Names    GHRL; MTLRP; ghrelin; ghrelin precursor; motilin-related peptide; preproghrelin; ghrelin/obestatin prepropeptide; obestatin; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; ghrelin, growth hormone secretagogue receptor liga; GHRL antibody; MTLRP antibody; ghrelin antibody; ghrelin precursor antibody; motilin-related peptide antibody; preproghrelin antibody; ghrelin/obestatin prepropeptide antibody; obestatin antibody; ghrelin/obestatin preprohormone antibody; OTTHUMP00000207794; antibody; OTTHUMP00000207795 antibody; OTTHUMP00000207796 antibody; OTTHUMP00000207798 antibody; ghrelin; growth hormone secretagogue receptor ligand antibody; ghrelin/obestatin antibody; Ghrelin preproprotein; Ghrelin preproprotein
 Product Gene Name   

anti-GHRL antibody

[Similar Products]
 Antibody/Peptide Pairs    Ghrelin preproprotein peptide (MBS425213) is used for blocking the activity of Ghrelin preproprotein antibody (MBS421239)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QDILWEEAKE APADK
 OMIM    605353
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Rat; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QDILWEEAKEAPADK, from the C Terminus of the protein sequence according to NP_057446.1; NP_001128413.1; NP_001128416.1; NP_001128417.1; NP_001128418.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise all reported isoforms.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10368
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GHRL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GHRL antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

 Application Notes for anti-GHRL antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Immunohistochemistry: In paraffin embedded Human Placenta shows staining of trophoblast cytoplasm. Recommended concentration, 2-5ug/ml.
Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as small as the calculated size of this preproprotein of approx.12.9kDa according to NP_057446.1 and of its derivatives. Therefore we cannot recommend an optimal concentration and the product is investigative grade.
Immunocytochemsitry: This antibody has been successfully used in ICC for rat neurons as described in the following paper: Stoyanova et al, Regul Pept.2009 Nov 27;158(1-3): 86-90, PMID: 19540881.
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 Immunohistochemistry (IHC) of anti-GHRL antibody    (2ug/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-GHRL antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GHRL. It may not necessarily be applicable to this product.
 NCBI GI #    7706519
 NCBI GeneID    51738
 NCBI Accession #    NP_057446.1 [Other Products]
 NCBI Related Accession #    NP_001128413.1; NP_001128416.1; NP_001128417.1; NP_001128418.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016362.4 [Other Products]
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 UniProt Secondary Accession #    Q86YP8; Q8TAT9; Q9H3R3; A8CF34; A8CF38; A8CF42; A8DN29; A8DN30 [Other Products]
 UniProt Related Accession #    Q9UBU3 [Other Products]
 Molecular Weight    9,972 Da
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 NCBI Official Full Name    appetite-regulating hormone isoform 1 preproprotein
 NCBI Official Synonym Full Names    ghrelin/obestatin prepropeptide
 NCBI Official Symbol    GHRL [Similar Products]
 NCBI Official Synonym Symbols   
MTLRP
[Similar Products]
 NCBI Protein Information    appetite-regulating hormone
 UniProt Protein Name    Appetite-regulating hormone
 UniProt Synonym Protein Names   
Growth hormone secretagogue; Growth hormone-releasing peptide; Motilin-related peptide; Protein M46
 Protein Family    Ghrelin
 UniProt Gene Name    GHRL [Similar Products]
 UniProt Synonym Gene Names    MTLRP; Ghrelin [Similar Products]
 UniProt Entry Name    GHRL_HUMAN
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 NCBI Summary for GHRL    This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]
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 UniProt Comments for GHRL    ghrelin: a hormone that binds to the growth hormone secretagogue receptor type 1 (GHSR). Secreted by the stomach

Protein type: Secreted; Secreted, signal peptide; Cell cycle regulation; Apoptosis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 3p26-p25

Cellular Component: axon; cytosol; endoplasmic reticulum lumen; extracellular region; extracellular space

Molecular Function: G-protein-coupled receptor binding; ghrelin receptor binding; growth hormone-releasing hormone activity; protein binding; protein tyrosine kinase activator activity

Biological Process: actin polymerization and/or depolymerization; activation of MAPK activity; adult feeding behavior; cartilage development; cortisol secretion; decidualization; dendrite development; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; gastric acid secretion; glucose metabolic process; growth hormone secretion; hormone-mediated signaling; negative regulation of angiogenesis; negative regulation of apoptosis; negative regulation of circadian sleep/wake cycle, REM sleep; negative regulation of endothelial cell proliferation; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of locomotion; negative regulation of tumor necrosis factor biosynthetic process; positive regulation of adrenocorticotropic hormone secretion; positive regulation of appetite; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of cortisol secretion; positive regulation of growth hormone secretion; positive regulation of insulin secretion; positive regulation of multicellular organism growth; positive regulation of synaptogenesis; regulation of cell proliferation; regulation of excitatory postsynaptic membrane potential; regulation of response to food; response to estrogen stimulus; response to hormone stimulus

Disease: Obesity
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 Research Articles on GHRL    1. Higher levels of ghrelin were associated with an increased risk of Barrett's esophagus among the general population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GHRL antibodyPathways associated with anti-GHRL antibody
 Reference Product  PubMed Publications
 GHSR antibody  >33 publications with GHRL and GHSR
 NPY antibody  >16 publications with GHRL and NPY
 LEP antibody  >13 publications with GHRL and LEP
 POMC antibody  >5 publications with GHRL and POMC
 INS antibody  >5 publications with GHRL and INS
 GHRH antibody  >4 publications with GHRL and GHRH
 GCG antibody  >4 publications with GHRL and GCG
 PPY antibody  >3 publications with GHRL and PPY
 GPR39 antibody  >1 publications with GHRL and GPR39
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-GHRL antibodyOrgans/Tissues associated with anti-GHRL antibody
 Disease Name  Pubmed Publications
 Obesity Antibodies  >66 publications with GHRL and Obesity
 Insulin Resistance Antibodies  >20 publications with GHRL and Insulin Resistance
 Weight Loss Antibodies  >18 publications with GHRL and Weight Loss
 Cardiovascular Diseases Antibodies  >16 publications with GHRL and Cardiovascular Diseases
 Weight Gain Antibodies  >14 publications with GHRL and Weight Gain
 Inflammation Antibodies  >12 publications with GHRL and Inflammation
 Cachexia Antibodies  >8 publications with GHRL and Cachexia
 Breast Neoplasms Antibodies  >7 publications with GHRL and Breast Neoplasms
 Kidney Diseases Antibodies  >6 publications with GHRL and Kidney Diseases
 Necrosis Antibodies  >5 publications with GHRL and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >93 publications with GHRL and Blood
 Stomach Antibodies  >33 publications with GHRL and Stomach
 Brain Antibodies  >28 publications with GHRL and Brain
 Connective Tissue Antibodies  >11 publications with GHRL and Connective Tissue
 Intestine Antibodies  >7 publications with GHRL and Intestine
 Prostate Antibodies  >2 publications with GHRL and Prostate
 Embryonic Tissue Antibodies  >1 publications with GHRL and Embryonic Tissue
 Lung Antibodies  >1 publications with GHRL and Lung
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