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anti-GluR1 antibody :: Rabbit GluR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS221804 anti-GluR1 antibody
Unit / Price
0.15 mL  /  $705 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GluR1, Polyclonal Antibody

 Also Known As   

RABBIT ANTI GluR1 (pSer831)

 Product Gene Name   

anti-GluR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P19490
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Chicken (Expected from Sequence), Dog (Expected from Sequence), Human (Expected from Sequence), Mouse (Expected from Sequence)
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 Specificity    This antibody is specific for rat glutamate receptor subunit 1 (GluR1) when phosphorylated at serine 831. GluR1, widely expressed throughout the nervous system, is a component of AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid receptors), which play a key role at excitatory synapses. Phosphorylation of Ser831 and Ser845 is reported to potentiate GluR1 function, suggesting a possible role in synaptic plasticity, learning and memory.
 Form/Format    Purified
Purified IgG - liquid
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 Perservative Stabilisers    0.09% Sodium Azide
0.01% Bovine Serum Albumin
50% Glycerol
 Immunogen    Synthetic phosphopeptide corresponding to amino acid sequence within GluR1 which includes phosphorylated Ser831.
Buffer Solution
 Antiserum Preparation    Antisera to phosphorylated GluR1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by sequential affinity chromatography on phospho- and dephosphopeptide affinity columns.
 Target Species    Rat
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 Preparation and Storage    Store at 4 degree C or -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
 Other Notes    Small volumes of anti-GluR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GluR1 antibody

   This antibody is specific for rat glutamate receptor subunit 1 (GluR1) when phosphorylated at serine 831. GluR1, widely expressed throughout the nervous system, is a component of AMPA receptors (alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid receptors), which play a key role at excitatory synapses. Phosphorylation of Ser831 and Ser845 is reported to potentiate GluR1 function, suggesting a possible role in synaptic plasticity, learning and memory.
 Applications Tested/Suitable for anti-GluR1 antibody   

Western Blot (WB)*

 Application Notes for anti-GluR1 antibody    Western Blot: This item detects a band of approximately 100 kDa in rat brain lysates.
Western Blotting: Maximum Dilution: 1/1000; Application Note: For the detection of phosphoproteins, serine phosphatase inhibitors such as 10mM Sodium Fluoride should be added to the sample buffer. Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background.
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NCBI/Uniprot data below describe general gene information for GluR1. It may not necessarily be applicable to this product.
 NCBI GI #    29789269
 NCBI GeneID    50592
 NCBI Accession #    NP_113796.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031608.1 [Other Products]
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 UniProt Primary Accession #    P19490 [Other Products]
 UniProt Related Accession #    P19490 [Other Products]
 Molecular Weight    101,555 Da
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 NCBI Official Full Name    glutamate receptor 1
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, AMPA 1
 NCBI Official Symbol    Gria1 [Similar Products]
 NCBI Official Synonym Symbols   
GluA1; gluR-A
[Similar Products]
 NCBI Protein Information    glutamate receptor 1; AMPA-selective glutamate receptor 1; GluR1; gluR-1; gluR-K1; glutamate receptor A; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA1 (alpha 1)
 UniProt Protein Name    Glutamate receptor 1
 UniProt Synonym Protein Names   
AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1
 UniProt Gene Name    Gria1 [Similar Products]
 UniProt Synonym Gene Names    Glur1; GluR-1; GluA1 [Similar Products]
 UniProt Entry Name    GRIA1_RAT
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 NCBI Summary for GluR1    mouse homolog may play a role in regulation of neuronal synaptic plasticity and conditioned reinforcement learning [RGD, Feb 2006]
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 UniProt Comments for GluR1    GluR1: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Expressed in granule and pyramidal cells in the hippocampal formation.

Protein type: Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Cellular Component: endoplasmic reticulum membrane; neuron projection; protein complex; cell surface; endoplasmic reticulum; early endosome; postsynaptic density; dendrite; integral to membrane; dendritic spine; excitatory synapse; cytosol; asymmetric synapse; postsynaptic membrane; recycling endosome; synaptic vesicle; membrane; cell soma; plasma membrane; ionotropic glutamate receptor complex; synapse; dendritic shaft; neuromuscular junction; cell junction

Molecular Function: identical protein binding; protein domain specific binding; protein homodimerization activity; myosin V binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; protein kinase binding; PDZ domain binding; small GTPase binding; protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; beta-2 adrenergic receptor binding; protein kinase A binding; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; adenylate cyclase binding

Biological Process: regulation of synaptic transmission; response to drug; response to peptide hormone stimulus; synaptic transmission, glutamatergic; response to toxin; response to lithium ion; response to arsenic; generation of action potential; regulation of synaptic plasticity; response to cocaine; response to organic cyclic substance; positive regulation of synaptic transmission; response to estradiol stimulus; synaptic transmission; long-term memory; spinal cord development; ionotropic glutamate receptor signaling pathway; receptor internalization; regulation of receptor recycling; response to electrical stimulus; positive regulation of membrane potential
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 Research Articles on GluR1    1. epigenetic up-regulation of BDNF by peripheral inflammation induces GluR1 phosphorylation at Ser-831 sites through activation of the phospholipase C-PKC signaling cascade, leading to the trafficking of GluA1 to pain-modulating neuronal synapses
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GluR1 antibodyDiseases associated with anti-GluR1 antibody
 Products by Pathway  Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >21 publications with GluR1 and Mental Disorders
 Nervous System Diseases Antibodies  >7 publications with GluR1 and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with GluR1 and Brain Diseases
 Memory Disorders Antibodies  >3 publications with GluR1 and Memory Disorders
 Anxiety Disorders Antibodies  >3 publications with GluR1 and Anxiety Disorders
 Disease Models, Animal Antibodies  >3 publications with GluR1 and Disease Models, Animal
 Pain Antibodies  >2 publications with GluR1 and Pain
 Heart Diseases Antibodies  >2 publications with GluR1 and Heart Diseases
 Neurobehavioral Manifestations Antibodies  >2 publications with GluR1 and Neurobehavioral Manifestations
 Sexual Dysfunctions, Psychological Antibodies  >2 publications with GluR1 and Sexual Dysfunctions, Psychological
Organs/Tissues associated with anti-GluR1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >37 publications with GluR1 and Brain
 Heart Antibodies  >1 publications with GluR1 and Heart
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