NP_000151.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,009 Da
NCBI Official Full Name
glucagon receptor
NCBI Official Synonym Full Names
glucagon receptor
NCBI Official Synonym Symbols
NCBI Protein Information
glucagon receptor; GL-R
UniProt Protein Name
Glucagon receptor
UniProt Synonym Gene Names
UniProt Entry Name
GLR_HUMAN
NCBI Summary for GCGR
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
UniProt Comments for GCGR
GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family.
Protein type: Receptor, GPCR; GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane; endosome
Molecular Function: peptide hormone binding; guanyl-nucleotide exchange factor activity; glucagon receptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; generation of precursor metabolites and energy; exocytosis; hormone-mediated signaling; regulation of blood pressure; energy reserve metabolic process; glucose homeostasis; G-protein signaling, adenylate cyclase activating pathway; response to nutrient; positive regulation of GTPase activity
Disease: Diabetes Mellitus, Noninsulin-dependent
Research Articles on GCGR
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Products associated with anti-GCGR antibody
Pathways associated with anti-GCGR antibody
Diseases associated with anti-GCGR antibody
Organs/Tissues associated with anti-GCGR antibody
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