NP_001018661.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
glucocorticoid receptor isoform beta
NCBI Official Synonym Full Names
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NCBI Protein Information
glucocorticoid receptor; OTTHUMP00000160084; OTTHUMP00000160085; OTTHUMP00000222851; OTTHUMP00000222854; OTTHUMP00000222855; OTTHUMP00000222858; glucocorticoid nuclear receptor variant 1; nuclear receptor subfamily 3 group C member 1
UniProt Protein Name
Glucocorticoid receptor
UniProt Synonym Protein Names
Nuclear receptor subfamily 3 group C member 1
UniProt Synonym Gene Names
UniProt Entry Name
GCR_HUMAN
NCBI Summary for NR3C1
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq]
UniProt Comments for NR3C1
GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described.
Protein type: Mitochondrial; Nuclear receptor; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 5q31.3
Cellular Component: nucleoplasm; membrane; mitochondrial matrix; cytoplasm; cytosol; nucleus
Molecular Function: protein dimerization activity; glucocorticoid receptor activity; protein binding; zinc ion binding; transcription factor activity; steroid binding
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; adrenal gland development; maternal behavior; regulation of glucocorticoid biosynthetic process; chromatin modification; signal transduction; glucocorticoid mediated signaling; glucocorticoid metabolic process; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; glucocorticoid receptor signaling pathway; gene expression; regulation of gluconeogenesis; positive regulation of transcription from RNA polymerase II promoter
Disease: Glucocorticoid Resistance, Generalized
Research Articles on NR3C1
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Products associated with anti-NR3C1 antibody
Pathways associated with anti-NR3C1 antibody
Diseases associated with anti-NR3C1 antibody
Organs/Tissues associated with anti-NR3C1 antibody
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