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anti-SLC2A4 antibody :: Rabbit Glucose Transporter GLUT4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175347
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glucose Transporter GLUT4 (SLC2A4), Polyclonal Antibody

 Also Known As   

Anti-Glucose Transporter GLUT4 antibody

 Product Synonym Names    Solute carrier family 2, facilitated glucose transporter member 4; solute carrier family 2(facilitated glucose transporter), member 4; insulin-responsive antibody; Glucose transporter GLUT 4 antibody; Glucose transporter type 4 antibody; Glucose transporter type 4 insulin responsive antibody; GLUT 4 antibody; GLUT-4 antibody; GLUT4 antibody; GTR4_HUMAN antibody; kug antibody; SLC 2A4 antibody; SLC2A4 antibody; solute carrier family 2(facilitated glucose transporter) member 4 antibody; Solute carrier family 2, facilitated glucose transporter member 4 antibody
 Product Gene Name   

anti-SLC2A4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138190
 3D Structure    ModBase 3D Structure for P14672
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human Glucose Transporter GLUT4 (491-509aa EQEVKPSTELEYLGPDEND), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SLC2A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SLC2A4 antibody

   Description: Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 4(SLC2A4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: Facilitated glucose transport by mammalian cells is not a property of a single protein but an activity associated with a family of structurally related proteins. Glucose transporter 4 is a insulin-responsive glucose transporter. It belongs to solute carrier family 2, member 1. Insulin alters the subcellular localization of GLUT4 vesicles in human muscle, and that this effect is impaired equally in insulin-resistant subjects with and without diabetes. A similar pattern of defects cause insulin resistance in human adipocytes.Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
 Applications Tested/Suitable for anti-SLC2A4 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Immunohistochemistry (IHC) of anti-SLC2A4 antibody    Anti-GLUT4 antibody, IHC(P)
IHC(P): Rat Cardiac Muscle Tissue
anti-SLC2A4 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-SLC2A4 antibody    Anti-GLUT4 antibody, Western blotting
All lanes: Anti GLUT4 at 0.5ug/ml
Lane 1: Rat Cardiac Muscle Tissue Lysate at 50ug
Lane 2: Rat Skeletal Muscle Tissue Lysate at 50ug
Lane 3: Mouse Cardiac Muscle Tissue Lysate at 50ug
Lane 4: Mouse Skeletal Muscle Tissue Lysate at 50ug
Lane 5: HELA Whole Cell Lysate at 40ug
Predicted bind size: 55 KD
Observed bind size: 55 KD
anti-SLC2A4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SLC2A4. It may not necessarily be applicable to this product.
 NCBI GI #    121761
 NCBI GeneID    6517
 NCBI Accession #    P14672.1 [Other Products]
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 UniProt Primary Accession #    P14672 [Other Products]
 UniProt Secondary Accession #    Q05BQ3; Q14CX2 [Other Products]
 UniProt Related Accession #    P14672 [Other Products]
 Molecular Weight    43,760 Da
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 NCBI Official Full Name    Solute carrier family 2, facilitated glucose transporter member 4
 NCBI Official Synonym Full Names    solute carrier family 2 (facilitated glucose transporter), member 4
 NCBI Official Symbol    SLC2A4 [Similar Products]
 NCBI Official Synonym Symbols   
GLUT4
[Similar Products]
 NCBI Protein Information    solute carrier family 2, facilitated glucose transporter member 4; GLUT-4; insulin-responsive glucose transporter type 4; glucose transporter type 4, insulin-responsive
 UniProt Protein Name    Solute carrier family 2, facilitated glucose transporter member 4
 UniProt Synonym Protein Names   
Glucose transporter type 4, insulin-responsive; GLUT-4
 Protein Family    Solute carrier family
 UniProt Gene Name    SLC2A4 [Similar Products]
 UniProt Synonym Gene Names    GLUT4; GLUT-4 [Similar Products]
 UniProt Entry Name    GTR4_HUMAN
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 NCBI Summary for SLC2A4    This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
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 UniProt Comments for SLC2A4    GLUT4: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: clathrin-coated vesicle; integral to plasma membrane; T-tubule; endomembrane system; coated pit; vesicle membrane; cytosol; lipid raft; multivesicular body; trans-Golgi network transport vesicle; membrane; perinuclear region of cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: D-glucose transmembrane transporter activity; protein binding; glucose transmembrane transporter activity

Biological Process: amylopectin biosynthetic process; response to ethanol; cellular response to insulin stimulus; hexose transport; glucose import; carbohydrate metabolic process; brown fat cell differentiation; pathogenesis; glucose transport; glucose homeostasis; transmembrane transport

Disease: Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on SLC2A4    1. findings suggest that the AA genotype and A allele of SLC2A4 promoter, rs5418 were associated with top-level endurance performance in the northern Han Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SLC2A4 antibodyPathways associated with anti-SLC2A4 antibody
 Reference Product  PubMed Publications
 TBC1D4 antibody  >35 publications with SLC2A4 and TBC1D4
 AKT2 antibody  >33 publications with SLC2A4 and AKT2
 STXBP3 antibody  >15 publications with SLC2A4 and STXBP3
 PRKAA2 antibody  >6 publications with SLC2A4 and PRKAA2
 RAB10 antibody  >6 publications with SLC2A4 and RAB10
 RAB8A antibody  >5 publications with SLC2A4 and RAB8A
 RAB14 antibody  >4 publications with SLC2A4 and RAB14
 Products by Pathway  Pathway Diagram
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 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with anti-SLC2A4 antibodyOrgans/Tissues associated with anti-SLC2A4 antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >844 publications with SLC2A4 and Insulin Resistance
 Hyperinsulinism Antibodies  >639 publications with SLC2A4 and Hyperinsulinism
 Diabetes Mellitus, Type 2 Antibodies  >299 publications with SLC2A4 and Diabetes Mellitus, Type 2
 Hyperglycemia Antibodies  >208 publications with SLC2A4 and Hyperglycemia
 Diabetes Mellitus, Experimental Antibodies  >182 publications with SLC2A4 and Diabetes Mellitus, Experimental
 Cardiovascular Diseases Antibodies  >156 publications with SLC2A4 and Cardiovascular Diseases
 Necrosis Antibodies  >91 publications with SLC2A4 and Necrosis
 Glucose Intolerance Antibodies  >85 publications with SLC2A4 and Glucose Intolerance
 Inflammation Antibodies  >72 publications with SLC2A4 and Inflammation
 Hypertension Antibodies  >68 publications with SLC2A4 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2465 publications with SLC2A4 and Muscle
 Heart Antibodies  >405 publications with SLC2A4 and Heart
 Brain Antibodies  >102 publications with SLC2A4 and Brain
 Kidney Antibodies  >81 publications with SLC2A4 and Kidney
 Lung Antibodies  >23 publications with SLC2A4 and Lung
 Placenta Antibodies  >18 publications with SLC2A4 and Placenta
 Intestine Antibodies  >14 publications with SLC2A4 and Intestine
 Bone Antibodies  >11 publications with SLC2A4 and Bone
 Prostate Antibodies  >5 publications with SLC2A4 and Prostate
 Adrenal Gland Antibodies  >5 publications with SLC2A4 and Adrenal Gland
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