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anti-GCPII antibody :: Rabbit anti-Human Glutamate Carboxypeptidase II Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2028247 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamate Carboxypeptidase II (GCPII), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Glutamate Carboxypeptidase II (GCPII)

 Product Gene Name   

anti-GCPII antibody

[Similar Products]
 Matching Pairs    Antibody: Glutamate Carboxypeptidase II (MBS2028247)
Antigen: Glutamate Carboxypeptidase II (MBS2029572)
 Matching Pairs    Unconjugated Antibody: Glutamate Carboxypeptidase II (MBS2028247)
APC-CY7 Conjugated Antibody: Glutamate Carboxypeptidase II (GCPII) (MBS2066317)
 Matching Pairs    Unconjugated Antibody: Glutamate Carboxypeptidase II (MBS2028247)
PE Conjugated Antibody: Glutamate Carboxypeptidase II (GCPII) (MBS2066318)
 Matching Pairs    Unconjugated Antibody: Glutamate Carboxypeptidase II (MBS2028247)
APC-CY7 Conjugated Antibody: Glutamate Carboxypeptidase II (GCPII) (MBS2066319)
 Matching Pairs    Unconjugated Antibody: Glutamate Carboxypeptidase II (MBS2028247)
Cy3 Conjugated Antibody: Glutamate Carboxypeptidase II (GCPII) (MBS2066320)
 Matching Pairs    Unconjugated Antibody: Glutamate Carboxypeptidase II (MBS2028247)
FITC Conjugated Antibody: Glutamate Carboxypeptidase II (GCPII) (MBS2066321)
 Matching Pairs    Unconjugated Antibody: Glutamate Carboxypeptidase II (MBS2028247)
HRP Conjugated Antibody: Glutamate Carboxypeptidase II (GCPII) (MBS2066322)
 Matching Pairs    Unconjugated Antibody: Glutamate Carboxypeptidase II (MBS2028247)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Glutamate Carboxypeptidase II (MBS2028247)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Glutamate Carboxypeptidase II (MBS2028247)
Biotin Conjugated Antibody: Glutamate Carboxypeptidase II (GCPII) (MBS2094600)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M99487 mRNA
 3D Structure    ModBase 3D Structure for Q04609
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against GCPII. It has beenselected for its ability to recognize GCPII in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    GCPII (Ala274~Leu587)
 Organism Species    Homo sapiens (Human)
 Immunogen    Recombinant GCPII (Ala274~Leu587) with two N-terminal Tags, His-tag and T7-tag expressed in E.coli.
 Accession No.    RPC512Hu01
 UOM    100ug
 Conjugate    No Conjugate
 Immunogen    Recombinant GCPII (Ala274~Leu587) expressed in E Coli.
 Form & Buffer    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2066319
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-GCPII antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GCPII antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-GCPII antibody    Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-200
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-GCPII antibody    (Figure. Western Blot; Sample: Rat Prostate Gland Tissue.)
anti-GCPII antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-GCPII antibody    (Figure. Western Blot; Sample: Recombinant GCPII, Human.)
anti-GCPII antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GCPII antibody    (Figure. DAB staining on IHC-P; Samples: Human Prostate Gland Cancer Tissue.)
anti-GCPII antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GCPII antibody    (Figure. DAB staining on IHC-P; Samples: Human Kidney Tissue.)
anti-GCPII antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GCPII antibody    (Figure. DAB staining on IHC-P; Samples: Human Prostate Gland Tissue.)
anti-GCPII antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GCPII. It may not necessarily be applicable to this product.
 NCBI GI #    62548858
 NCBI GeneID    2346
 NCBI Accession #    NP_001014986.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001014986.2 [Other Products]
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 UniProt Primary Accession #    Q04609 [Other Products]
 UniProt Secondary Accession #    O43748; Q16305; Q541A4; Q8TAY3; Q9NP15; A4UU12; A9CB79; B7Z312; B7Z343; D3DQS5; E9PDX8 [Other Products]
 UniProt Related Accession #    Q04609 [Other Products]
 Molecular Weight    50,090 Da
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 NCBI Official Full Name    glutamate carboxypeptidase 2 isoform 2
 NCBI Official Synonym Full Names    folate hydrolase 1
 NCBI Official Symbol    FOLH1 [Similar Products]
 NCBI Official Synonym Symbols   
PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase
[Similar Products]
 NCBI Protein Information    glutamate carboxypeptidase 2
 UniProt Protein Name    Glutamate carboxypeptidase 2
 UniProt Synonym Protein Names   
Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; PSM; PSMA; Pteroylpoly-gamma-glutamate carboxypeptidase
 UniProt Gene Name    FOLH1 [Similar Products]
 UniProt Synonym Gene Names    FOLH; NAALAD1; PSM; PSMA; FGCP; GCPII; mGCP; NAALADase I; PSM; PSMA [Similar Products]
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 NCBI Summary for GCPII    This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
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 UniProt Comments for GCPII    FOLH1: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Belongs to the peptidase M28 family. M28B subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.17.21; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 11p11.12

Cellular Component: cell surface; cytoplasm; integral component of plasma membrane; membrane; plasma membrane

Molecular Function: dipeptidase activity; metal ion binding; metallocarboxypeptidase activity; peptidase activity

Biological Process: amino acid biosynthetic process; folic acid-containing compound metabolic process; proteolysis
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 Research Articles on GCPII    1. results demonstrate both the feasibility of preparing PSMA-targeted MBs and the benefits of using bioorthogonal chemistry to create targeted US probes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GCPII antibodyDiseases associated with anti-GCPII antibody
 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Vitamin Digestion And Absorption Pathway antibodies  Vitamin Digestion And Absorption Pathway Diagram
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >10 publications with GCPII and Prostatic Neoplasms
 Brain Diseases Antibodies  >3 publications with GCPII and Brain Diseases
 Musculoskeletal Diseases Antibodies  >2 publications with GCPII and Musculoskeletal Diseases
 Heart Diseases Antibodies  >2 publications with GCPII and Heart Diseases
 Nervous System Diseases Antibodies  >2 publications with GCPII and Nervous System Diseases
 Death Antibodies  >2 publications with GCPII and Death
 Lung Neoplasms Antibodies  >2 publications with GCPII and Lung Neoplasms
 Necrosis Antibodies  >2 publications with GCPII and Necrosis
 Nerve Degeneration Antibodies  >1 publications with GCPII and Nerve Degeneration
 Hypertension Antibodies  >1 publications with GCPII and Hypertension
Organs/Tissues associated with anti-GCPII antibody
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >17 publications with GCPII and Prostate
 Brain Antibodies  >7 publications with GCPII and Brain
 Kidney Antibodies  >4 publications with GCPII and Kidney
 Bone Antibodies  >2 publications with GCPII and Bone
 Intestine Antibodies  >2 publications with GCPII and Intestine
 Nerve Antibodies  >2 publications with GCPII and Nerve
 Muscle Antibodies  >1 publications with GCPII and Muscle
 Liver Antibodies  >1 publications with GCPII and Liver
 Salivary Gland Antibodies  >1 publications with GCPII and Salivary Gland
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