NP_000824.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
144,431 Da
NCBI Official Full Name
glutamate receptor ionotropic, NMDA 2A isoform 1
NCBI Official Synonym Full Names
glutamate ionotropic receptor NMDA type subunit 2A
NCBI Official Synonym Symbols
LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A [Similar Products]
NCBI Protein Information
glutamate receptor ionotropic, NMDA 2A
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 2A
UniProt Synonym Protein Names
Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A
UniProt Synonym Gene Names
NCBI Summary for GRIN2A
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Comments for GRIN2A
NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16p13.2
Cellular Component: cell junction; cell surface; endoplasmic reticulum; integral component of plasma membrane; integral component of postsynaptic density membrane; neuron projection; NMDA selective glutamate receptor complex; plasma membrane; postsynaptic density; presynaptic membrane; synaptic vesicle
Molecular Function: extracellular-glutamate-gated ion channel activity; glutamate-gated calcium ion channel activity; NMDA glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding
Biological Process: calcium-mediated signaling; cellular response to amyloid-beta; directional locomotion; dopamine metabolic process; excitatory postsynaptic potential; glutamate receptor signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPK cascade; memory; negative regulation of protein catabolic process; neurogenesis; positive regulation of apoptosis; positive regulation of long-term synaptic potentiation; protein localization; regulation of molecular function; regulation of sensory perception of pain; response to amphetamine; response to drug; response to ethanol; response to wounding; sensory perception of pain; serotonin metabolic process; sleep; startle response; synaptic transmission; transport; visual learning
Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation
Research Articles on GRIN2A
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Products associated with anti-GRIN2A antibody
Diseases associated with anti-GRIN2A antibody
Organs/Tissues associated with anti-GRIN2A antibody
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